ID   MUTS_VIBPA              Reviewed;         853 AA.
AC   Q87LQ9;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2003, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=VP2552;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BA000031; BAC60815.1; -; Genomic_DNA.
DR   RefSeq; NP_798931.1; NC_004603.1.
DR   RefSeq; WP_005478546.1; NC_004603.1.
DR   AlphaFoldDB; Q87LQ9; -.
DR   SMR; Q87LQ9; -.
DR   STRING; 223926.28807550; -.
DR   PRIDE; Q87LQ9; -.
DR   EnsemblBacteria; BAC60815; BAC60815; BAC60815.
DR   GeneID; 1190076; -.
DR   KEGG; vpa:VP2552; -.
DR   PATRIC; fig|223926.6.peg.2450; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..853
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115165"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   853 AA;  94972 MW;  ED3AD3A69A7F7CE7 CRC64;
     MKAEQKHTPM MQQYLKLKAE NPEILLFYRM GDFYELFYDD AKRASQLLDI SLTKRGSSAG
     EPIPMAGVPF HAVEGYLAKL VQLGESVAIC EQIGDPATSK GPVERKVVRI VTPGTVTDEA
     LLSERLDNLI AAIYHHNGKF GYATLDVTSG RFQLTEPETE EAMMAELQRT APRELLFPED
     FEPVHLMSNR NGNRRRPVWE FELDTAKQQL NQQFGTRDLV GFGVEHASLG LCAAGCLIQY
     VKDTQRTALP HIRSLTFDRQ DHSVILDAAT RRNLEITQNL AGGTDNTLAA VLDHCSTPMG
     SRMLKRWLHQ PMRCIDTLNN RLDAIGEIKD QGLFTDLQPT LKQIGDIERI LARLALRSAR
     PRDMARLRHA MQQLPELESL TASLTHPYLV KLAQYAAPID EVCELLERAI KENPPVVIRD
     GGVIAEGYNE ELDEWRKLAD GATEYLEKLE ADERERHGID TLKVGYNAVH GFFIQVSRGQ
     SHLVPPHYVR RQTLKNAERY IIPELKEHED KVLNSKSKAL ALEKKLWEEL FDLLMPHLEQ
     MQNLASAVSQ MDVLQNLAER ADSLDYCRPT LVKDAGIHIQ AGRHPVVEQV TSDPFIANPI
     ELSPSRKMLI ITGPNMGGKS TYMRQTALIA LMAHIGSYVP AESAQIGSLD RIFTRIGASD
     DLASGRSTFM VEMTETANIL HNATKNSLVL MDEIGRGTST YDGLSLAWAS AEWLATQIGA
     MTLFATHYFE LTELPNLLPN LANVHLDAVE HGDSIAFMHA VQEGAASKSY GLAVAGLAGV
     PKTVIKNART KLSQLEQLGQ ASDSPRPSTV DVANQLSLIP EPSEIEQALS NIDPDDLTPR
     QALEELYRLK KML