ID   MUTS_VIBVY              Reviewed;         853 AA.
AC   Q7MHR2;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=VV2806;
OS   Vibrio vulnificus (strain YJ016).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=196600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJ016;
RX   PubMed=14656965; DOI=10.1101/gr.1295503;
RA   Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA   Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA   Lee C.-T., Hor L.-I., Tsai S.-F.;
RT   "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL   Genome Res. 13:2577-2587(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC95571.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000037; BAC95571.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_043877315.1; NC_005139.1.
DR   AlphaFoldDB; Q7MHR2; -.
DR   SMR; Q7MHR2; -.
DR   STRING; 672.VV93_v1c25180; -.
DR   EnsemblBacteria; BAC95571; BAC95571; BAC95571.
DR   KEGG; vvy:VV2806; -.
DR   PATRIC; fig|196600.6.peg.2798; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002675; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..853
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115167"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   853 AA;  94485 MW;  4525B67031103E96 CRC64;
     MKAEQQHTPM MQQYLRLKAE NPDILLFYRM GDFYELFYDD AKKASQLLDI SLTKRGASAG
     EPIPMAGVPF HAVEGYLAKL VQLGESVAIC EQVGDPATSK GPVERKVVRI VTPGTVTDEA
     LLSERLDNLI AAIYHHNGKF GYATLDVTSG RFQLVEPQSE EAMAAELQRT SPRELLFPED
     FEPVHLMTGR NGNRRRPVWE FELETAKQQL NQQFGTKDLV GFGVENAMLG LCAAGCLIQY
     VKDTQRTALP HIRALTYDRQ DDSVILDAAT RRNLELTQNL AGGSDNTLAA VLDRCATPMG
     SRMLKRWIHQ PMRCITTREH RLDAIAELKE QALFSDIHPV VKQIGDIERI LARLALRSAR
     PRDLARLRHA MQQLPELAQT LSSLGNSHLK SLATAAAPMD DVCELLERAI KENPPVVIRD
     GGVIAEGYSA DLDEWRDLAD GATGYLEKLE EEERDRHGID TLKVGYNNVH GFYIQVSRGQ
     SHLVPPHYVR RQTLKNAERY IIPELKEHED KVLNSKSKAL AIEKQLWEEL FDLLLPHLAR
     LQELAAAVAQ LDVLQNLAER ADTLDYCRPN LTKDPVVHIT AGRHPVVEQV TSDPFIANPI
     ELNSQRKMLI ITGPNMGGKS TYMRQTALIA LMAHIGSYVP AESATIGSID RIFTRIGASD
     DLASGRSTFM VEMTETANIL HNATANSLVL MDEIGRGTST YDGLSLAWAS AHWLATQIGA
     MTLFATHYFE LTELPNQLPH LANVHLDAVE HGDSIAFMHA VQEGAASKSY GLAVAGLAGV
     PKTVIKNARQ KLSQLELLSA EGSQPKARTV DIANQLSLIP EPSEVEQALA SIDPDDLTPR
     QALEALYRLK KML