ID   MUTS_WOLPM              Reviewed;         849 AA.
AC   P61673;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=WD_0190;
OS   Wolbachia pipientis wMel.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Wolbachieae; Wolbachia; unclassified Wolbachia.
OX   NCBI_TaxID=163164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15024419; DOI=10.1371/journal.pbio.0020069;
RA   Wu M., Sun L.V., Vamathevan J.J., Riegler M., DeBoy R.T., Brownlie J.C.,
RA   McGraw E.A., Martin W., Esser C., Ahmadinejad N., Wiegand C., Madupu R.,
RA   Beanan M.J., Brinkac L.M., Daugherty S.C., Durkin A.S., Kolonay J.F.,
RA   Nelson W.C., Mohamoud Y., Lee P., Berry K.J., Young M.B., Utterback T.R.,
RA   Weidman J.F., Nierman W.C., Paulsen I.T., Nelson K.E., Tettelin H.,
RA   O'Neill S.L., Eisen J.A.;
RT   "Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a
RT   streamlined genome overrun by mobile genetic elements.";
RL   PLoS Biol. 2:327-341(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS13936.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE017196; AAS13936.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P61673; -.
DR   SMR; P61673; -.
DR   STRING; 163164.WD_0190; -.
DR   EnsemblBacteria; AAS13936; AAS13936; WD_0190.
DR   KEGG; wol:WD_0190; -.
DR   eggNOG; COG0249; Bacteria.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000008215; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..849
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115168"
FT   BINDING         665..672
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   849 AA;  95281 MW;  3A4EB5E35AE5B9FD CRC64;
     MCNIIYNNVY QYNILKNIMS FVKEKNTPVM EQYLNLKAQY KDHLLFYRLG DFYELFFDDA
     IKAAKLLNIV LTKRGNSCGQ EIPMCGVPAH SSESYLHKLI DLGFKVAICD QLETADEAKK
     RGYKSIVKRD VVRVVTPGTI IEDSLLEDKS NNYLASIVEQ NDEYAISWLE LSTGKFFHTL
     TSLKALDSDL LRISPRELLI SEKFTEDEKI RSILKNYKIS ITQHAQSFFE YSKSHRTLCE
     FYKIRELGSI GNFSKVEIMA CGALLEYVRV TQRGSIPRLE FPKTYKQQNF MLIDTSARRN
     LELFSTQFGE KKGSLISVID HTVTASGGRL LKQMLASPLA CSKAINLRLS TAQFFVNNHD
     SRRKIREILS NIPDIERSLS RLILGRGSPK DMNLLKIGLG KTLELSEFLC KIESGENGSL
     PQQYVIQTEI QPASRAGITV KSDESELSTI HKSLGNHKDL FELLNSAILD NNLSSVKEGG
     FIHSKYNSEL SELSYILNNS NKLVTKLRES YRDLTGIAAL KILHNNILGY YVEVSANHKI
     TSDIFIHRQS LANSMRYTTN ELKELENKIL TARDAAIGLE MKIFSELCSE VAKESEKIAL
     AANALAKLDI RTAFAELAVQ NNYVKPIIDD SKEFNICSGR HPVVEVNDKF IANSINLAGI
     HLITGPNMAG KSTFLRQNAL IAILAHMGSF VPAESAHIGV IDKIFSRVGA TDNITAGYST
     FMVEMIETAT IVNQATDRSL VILDEIGRGT GVYDGLSIAQ AVIEHIHNVN KCRAIFATHY
     HELTKVSKYL KNVKCFCVKI REWNGEVIFL HEVIEGIADE SYGIHVAKLA GFPDSVLNRA
     SEVFEELKA