ID   MUTS_WOLWR              Reviewed;         854 AA.
AC   C0R5H4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=WRi_001780;
OS   Wolbachia sp. subsp. Drosophila simulans (strain wRi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Wolbachieae; Wolbachia; unclassified Wolbachia.
OX   NCBI_TaxID=66084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=wRi;
RX   PubMed=19307581; DOI=10.1073/pnas.0810753106;
RA   Klasson L., Westberg J., Sapountzis P., Naeslund K., Lutnaes Y.,
RA   Darby A.C., Veneti Z., Chen L., Braig H.R., Garrett R., Bourtzis K.,
RA   Andersson S.G.;
RT   "The mosaic genome structure of the Wolbachia wRi strain infecting
RT   Drosophila simulans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:5725-5730(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001391; ACN95016.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0R5H4; -.
DR   SMR; C0R5H4; -.
DR   STRING; 66084.WRi_001780; -.
DR   EnsemblBacteria; ACN95016; ACN95016; WRi_001780.
DR   KEGG; wri:WRi_001780; -.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001293; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..854
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118703"
FT   BINDING         670..677
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   854 AA;  95977 MW;  28F9D1B23202318C CRC64;
     MCNIIYNNVY QYNILKNIMS FVKEKNTPVM EQYLNLKAQY KDHLLFYRLG DFYELFFDDA
     IKAAKLLNIV LTKRGNSCGQ DIPMCGVPAH SSESYLHKLI DLGFKVAICD QLETADEAKK
     RGYKSIVKRD VVRVVTPGTI IEDSLLEDKS NNYLASIVEQ NDEYAISWLE LSTGKFFHTL
     TSLKALDSDL LRISPRELLI SEKFTEDEKI RSVLKNYKIS ITQHAQSFFE YSKSHRTLCE
     FYKIRELGSI GNFSKVEIMA CGALLEYVRV TQRGSIPRLE FPKTYKQQNF MLIDASARRN
     LELFSTQFGE KKGSLISVID HTVTASGGRL LKQMLASPLA CSKAINLRLS TAQFFVNNHE
     PRRKIREILS NIPDIERSLS RLILGRGSPK DMNLLKIGLG KTLELSEFLS TLHNYCLSEK
     SEINSQMSFQ CLTKEKEPVS TTQVISSDES ELSTIHKSLG NHKDLFELLN SAILDNNLSS
     VKEGGFIHSK YNSELSELSY ILNNSNKLVT KLRESYRDLT GIAALKILHN NILGYYVEVS
     ANHKITSDIF IHRQSLANSM RYTTNELKEL ENKILTARDA AIGLEMKIFS ELCSEVAKES
     EKIALAANAL AKLDIRTAFA ELAVQNNYVK PIIDDSKEFN ICSGRHPVVE VNNKFIANSI
     NLAGIHLITG PNMAGKSTFL RQNALIAVLA HMGSFVPAES AHIGVIDKIF SRVGATDNIT
     AGYSTFMVEM IETATIVNQA TDRSLVILDE IGRGTGVYDG LSIAQAVIEH IHNVNKCRAI
     FATHYHELTK VSKYLKNVKC FCVKIREWNG EVIFLHEVIE GIADESYGIH VAKLAGFPDS
     VLNRASEVFE ELKA