ID   MUTS_XANC5              Reviewed;         873 AA.
AC   Q3BVY0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=XCV1352;
OS   Xanthomonas campestris pv. vesicatoria (strain 85-10).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=316273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=85-10;
RX   PubMed=16237009; DOI=10.1128/jb.187.21.7254-7266.2005;
RA   Thieme F., Koebnik R., Bekel T., Berger C., Boch J., Buettner D.,
RA   Caldana C., Gaigalat L., Goesmann A., Kay S., Kirchner O., Lanz C.,
RA   Linke B., McHardy A.C., Meyer F., Mittenhuber G., Nies D.H.,
RA   Niesbach-Kloesgen U., Patschkowski T., Rueckert C., Rupp O., Schneiker S.,
RA   Schuster S.C., Vorhoelter F.J., Weber E., Puehler A., Bonas U., Bartels D.,
RA   Kaiser O.;
RT   "Insights into genome plasticity and pathogenicity of the plant pathogenic
RT   Bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete
RT   genome sequence.";
RL   J. Bacteriol. 187:7254-7266(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM039952; CAJ22983.1; -; Genomic_DNA.
DR   RefSeq; WP_011346798.1; NZ_CP017190.1.
DR   AlphaFoldDB; Q3BVY0; -.
DR   SMR; Q3BVY0; -.
DR   STRING; 456327.BJD11_15920; -.
DR   PRIDE; Q3BVY0; -.
DR   EnsemblBacteria; CAJ22983; CAJ22983; XCV1352.
DR   KEGG; xcv:XCV1352; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000007069; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..873
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224418"
FT   BINDING         625..632
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   873 AA;  95750 MW;  BAFB4E9577D9C1D9 CRC64;
     MQSTDTKEKN KNASGAVEHT PLMKQFFAAK SDYPDLLLFF RMGDFYELFY DDARKAARLL
     DITLTQRGSS GGAPIPMAGV PVHAYEGYLA RLVALGESVA ICEQIGDPAL AKGLVERKVV
     RIVTPGTVTD EALLDERRDT LLMAISRSKH GYGLAWADLA GGRFLVNEVD SADALEAEIA
     RLEPAELLVP DEDNWPDFLR GRTGVRRRPP WLFDADSGRR QLLAFFKLHD LSGFGIDDKP
     CATAAAGALL GYVEETQKQR LPHLTSIAME VASEAISMNA ATRRHLELDT RVDGDTRNTL
     LGVLDSTVTP MGGRLLRRWL HRPLRLRDVL LQRHHAVGTL IDAGADADLR EAFRALGDLE
     RILTRVALRS ARPRDFSTLR DGLALLPKVR TILAPLDSPR LQTLHAELGE HDATAHLLIS
     AVAETPPLKL SDGGVIATGY DAELDELRRL STNADQFLID LEQRERASSG IATLKVGYNR
     VHGYYIEISK GQAEKAPLHY SRRQTLTNAE RYITEELKSF EDKVLSARER SLSREKLLYE
     GLLDALGTEL EGLKRCAGAL SELDVLAGFA ERAQALDWSQ PELDHAPCLR IEHGRHPVVE
     AVREQPFEPN DLDLHSDRRM LVITGPNMGG KSTYMRQNAL IVLLAHIGSY VPASRAVIGP
     IDRILTRIGA GDDLARGQST FMVEMAETSY ILHHATPQSL VLMDEIGRGT STYDGLALAD
     AVARHLAHTN RCYTLFATHY FELTALADES HAGGASGIAN VHLDAVEHGE RLVFMHAVKD
     GPANRSFGLQ VAALAGLPKA AVTQARRRLV ELEQRGGESH SAQMAPTALD APQQFGLFTA
     PSSAAQEALQ ALDPDELTPK QALEALYRLK ALL