ID   MUTS_XANC8              Reviewed;         873 AA.
AC   Q4US90;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=XC_3035;
OS   Xanthomonas campestris pv. campestris (strain 8004).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=314565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=8004;
RX   PubMed=15899963; DOI=10.1101/gr.3378705;
RA   Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q.,
RA   Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S.,
RA   Gu W.-Y., Lu G., Rong L., Tian Y., Yao Z., Fu G., Chen B., Fang R.,
RA   Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C.;
RT   "Comparative and functional genomic analyses of the pathogenicity of
RT   phytopathogen Xanthomonas campestris pv. campestris.";
RL   Genome Res. 15:757-767(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAY50083.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000050; AAY50083.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_043877810.1; NC_007086.1.
DR   AlphaFoldDB; Q4US90; -.
DR   SMR; Q4US90; -.
DR   EnsemblBacteria; AAY50083; AAY50083; XC_3035.
DR   KEGG; xcb:XC_3035; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   Proteomes; UP000000420; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..873
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224417"
FT   BINDING         625..632
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   873 AA;  95658 MW;  3CCCD0F98D4D354D CRC64;
     MQTADTKDKT KLSTGAAEHT PLMKQFFAAK SDYPDLLLFF RMGDFYELFY DDARKAARLL
     DITLTQRGSS GGAPIPMAGV PVHAYEGYLA RLVALGESVA ICEQIGDPAL AKGLVERKVV
     RIVTPGTVTD EALLDERRDT LLMAISRSKQ GYGLAWADLA GGRFLVNEVD SVDALEAEIA
     RLEPAELLVP DEDNWPEFLR GRVGVRRRPP WLFDADSGRR QLLAFFKLHD LSGFGIDDKP
     CATAAAGALL GYVEETQKQR LPHLTSIAME VASEAISMNA ATRRHLELDT RVDGDTRNTL
     LGVLDSTVTP MGGRLLRRWL HRPLRLREVL VQRHHAVGSL IDTGADTDVR EAFRALGDLE
     RILTRVALRS ARPRDFSTLR DGLALLPKVR TILAPLDSPR LQTLYAELGE HDATAHLLIS
     AVAEQPPLKF SDGGVIATGY DADLDELRRL STNADQFLID LEQRERASSG IATLKVGYNR
     VHGYYIEISK GQAEKAPLHY SRRQTLTNAE RYITEELKSF EDKVLSARER SLSREKLLYE
     GLLDALGGEL EGLKRCASAL SELDVLAGFA ERAQALDWSQ PELESAPCLH IERGRHPVVE
     AVRDQPFEPN DLDLHPDRRM LVITGPNMGG KSTYMRQNAL IVLLAHIGSY VPASRAVIGP
     IDRILTRIGA GDDLARGQST FMVEMAETSY ILHHATPQSL VLMDEIGRGT STYDGLALAD
     AVARHLAHTN RCYTLFATHY FELTALADAS HAGGGSGIAN VHLDAVEHGE RLVFMHAVKD
     GPANRSFGLQ VAALAGLPKA AVQQARRRLA ELEQRGGDSH AAEMAPAALD APQQFGLFTA
     PSSAAQEALQ ALDPDELTPK QALEALYRLK ALL