MUTS_XANCP
ID MUTS_XANCP Reviewed; 891 AA.
AC Q8PBB5;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=XCC1207;
OS Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB
OS 528 / LMG 568 / P 25).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Xanthomonas.
OX NCBI_TaxID=190485;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25;
RX PubMed=12024217; DOI=10.1038/417459a;
RA da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R.,
RA Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr.,
RA Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G.,
RA Cannavan F., Cardozo J., Chambergo F., Ciapina L.P., Cicarelli R.M.B.,
RA Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B.,
RA Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F.,
RA Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T.,
RA Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A.,
RA Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J.,
RA Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M.,
RA Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A.,
RA Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A.,
RA Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M.,
RA Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P.;
RT "Comparison of the genomes of two Xanthomonas pathogens with differing host
RT specificities.";
RL Nature 417:459-463(2002).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AE008922; AAM40505.1; -; Genomic_DNA.
DR RefSeq; NP_636581.1; NC_003902.1.
DR AlphaFoldDB; Q8PBB5; -.
DR SMR; Q8PBB5; -.
DR STRING; 340.xcc-b100_3132; -.
DR EnsemblBacteria; AAM40505; AAM40505; XCC1207.
DR KEGG; xcc:XCC1207; -.
DR PATRIC; fig|190485.4.peg.1297; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_6; -.
DR OMA; TPMMAQY; -.
DR Proteomes; UP000001010; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..891
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115170"
FT BINDING 643..650
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 891 AA; 97931 MW; 6AC637B622D654BF CRC64;
MRPIDRQIYR PPDFRTTFLQ TADTKDKTKL STGAAEHTPL MKQFFAAKSD YPDLLLFFRM
GDFYELFYDD ARKAARLLDI TLTQRGSSGG APIPMAGVPV HAYEGYLARL VALGESVAIC
EQIGDPALAK GLVERKVVRI VTPGTVTDEA LLDERRDTLL MAISRSKQGY GLAWADLAGG
RFLVNEVDSV DALEAEIARL EPAELLVPDE DNWPEFLRGR VGVRRRPPWL FDADSGRRQL
LAFFKLHDLS GFGIDDKPCA TAAAGALLGY VEETQKQRLP HLTSIAMEVA SEAISMNAAT
RRHLELDTRV DGDTRNTLLG VLDSTVTPMG GRLLRRWLHR PLRLREVLVQ RHHAVGSLID
TGADTDVREA FRALGDLERI LTRVALRSAR PRDFSTLRDG LALLPKVRTI LAPLDSPRLQ
TLYAELGEHD ATAHLLISAV AEQPPLKFSD GGVIATGYDA DLDELRRLST NADQFLIDLE
QRERASSGIA TLKVGYNRVH GYYIEISKGQ AEKAPLHYSR RQTLTNAERY ITEELKSFED
KVLSARERSL SREKLLYEGL LDALGGELEG LKRCASALSE LDVLAGFAER AQALDWSQPE
LESAPCLHIE RGRHPVVEAV RDQPFEPNDL DLHPDRRMLV ITGPNMGGKS TYMRQNALIV
LLAHIGSYVP ASRAVIGPID RILTRIGAGD DLARGQSTFM VEMAETSYIL HHATPQSLVL
MDEIGRGTST YDGLALADAV ARHLAHTNRC YTLFATHYFE LTALADASHA GGGSGIANVH
LDAVEHGERL VFMHAVKDGP ANRSFGLQVA ALAGLPKAAV QQARRRLAEL EQRGGDSHAA
EMAPAALDAP QQFGLFTAPS SAAQEALQAL DPDELTPKQA LEALYRLKAL L
