ID   MUTS_XANOR              Reviewed;         873 AA.
AC   Q5H2C5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=XOO1642;
OS   Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=291331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KACC10331 / KXO85;
RX   PubMed=15673718; DOI=10.1093/nar/gki206;
RA   Lee B.-M., Park Y.-J., Park D.-S., Kang H.-W., Kim J.-G., Song E.-S.,
RA   Park I.-C., Yoon U.-H., Hahn J.-H., Koo B.-S., Lee G.-B., Kim H.,
RA   Park H.-S., Yoon K.-O., Kim J.-H., Jung C.-H., Koh N.-H., Seo J.-S.,
RA   Go S.-J.;
RT   "The genome sequence of Xanthomonas oryzae pathovar oryzae KACC10331, the
RT   bacterial blight pathogen of rice.";
RL   Nucleic Acids Res. 33:577-586(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE013598; AAW74896.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5H2C5; -.
DR   SMR; Q5H2C5; -.
DR   STRING; 291331.XOO1642; -.
DR   PRIDE; Q5H2C5; -.
DR   EnsemblBacteria; AAW74896; AAW74896; XOO1642.
DR   KEGG; xoo:XOO1642; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000006735; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..873
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224419"
FT   BINDING         625..632
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   873 AA;  95829 MW;  D33466BC4E8624B3 CRC64;
     MQTTDFNTKA SSPKSTAEHT PLMKQFFAAK SDYPDLLLFF RMGDFYELFY DDARKAARLL
     DITLTQRGSS GGAPIPMAGV PVHAYEGYLA RLVALGESVA ICEQIGDPAL AKGLVERKVV
     RIVTPGTVTD EALLDERRDT LLMAISRSKQ GYGLAWADLA GGRFLVNEVD TVDALEAEIA
     RLEPAELLVP DEDHWPEFLR GRIGVRRRPP WLFDADSGRR QLLAFFKLHD LSGFGIDDKP
     SATAAAGALL GYVEETQKQR LPHLTSIATE VASEAISMNA ATRRHLELDT RVDGDTRNTL
     LGVLDSTVTP MGGRLLRRWL HRPLRLRDVL VQRHHAVGNL IDAGADADLR EAFRALGDLE
     RILTRVALRS ARPRDFSTLR DGLALLPKVR TILAPLDSPR LQTLHAELGE HDATAHLLIS
     AVAETPPLKL SDGGVIASGY DAELDELRRL STNADQFLID LEQRERASSG IATLKVGYNR
     VHGYYIEISK GQAEKAPLHY SRRQTLTNAE RYITEELKTF EDKVLSARER SLSREKLLYE
     GLLDTLGTEL EGLKRCAGAL SELDVLAGFA ERAQALDWSQ PELDSAPCLR IERGRHPVVE
     AVRDHPFEPN DLDLHSDRRM LVITGPNMGG KSTYMRQNAL IVLLAHIGSY VPASRAVIGP
     IDRILTRIGA GDDLARGQST FMVEMAETSY ILHHATPQSL VLMDEIGRGT STYDGLALAD
     AVARHLAHTN RCYTLFATHY FELTALADES HDGGASGIAN VHLDAVEHGE RLVFMHAVKD
     GPANRSFGLQ VAALAGLPKA AVTQARRRLV ELEQRGGESH SAQMAPTALD APQQFGLFTA
     PSSAAQEALQ ALDPDELTPK QALEALYRLK ALL