ID   MUTS_YERP3              Reviewed;         851 AA.
AC   A7FLX1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=YpsIP31758_3292;
OS   Yersinia pseudotuberculosis serotype O:1b (strain IP 31758).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=349747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP 31758;
RX   PubMed=17784789; DOI=10.1371/journal.pgen.0030142;
RA   Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G.,
RA   Fayolle C., Lindler L.E., Carniel E., Ravel J.;
RT   "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the
RT   causative agent of Far East scarlet-like fever.";
RL   PLoS Genet. 3:1508-1523(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000720; ABS47648.1; -; Genomic_DNA.
DR   RefSeq; WP_011191781.1; NC_009708.1.
DR   AlphaFoldDB; A7FLX1; -.
DR   SMR; A7FLX1; -.
DR   EnsemblBacteria; ABS47648; ABS47648; YpsIP31758_3292.
DR   GeneID; 66842801; -.
DR   KEGG; ypi:YpsIP31758_3292; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002412; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..851
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000057639"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   851 AA;  94786 MW;  DF141372BE6F3D13 CRC64;
     MKNNDKLDSH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YSDAKRASQL LDISLTKRGA
     SAGEPIPMAG VPYHSIENYL AKLVQLGESA AICEQIGDPA TSKGPVERKV VRIVTPGTIS
     DEALLQERQD NLLAAIWQDA KGFGYATLDI SSGRFRVAEP ADLETMAAEL QRTNPAELLY
     PENFEPMSLI EHRHGLRRRP LWEFELDTAK QQLNLQFGTR DLIGFGVEQA HLALRAAGCL
     LQYVKDTQRT SLPHIRGLTM ERQQDGIIMD AATRRNLELT QNLSGGSENT LAAILDCSVT
     PMGSRMLKRW LHMPIRDIRV LTDRQQAIGG LQDIAAELQT PLRQVGDLER ILARLALRTA
     RPRDLARMRH AFQQLPEIHR LLQPIDVPHV QNLLSQVGQF DELQDLLERA IVETPPVLVR
     DGGVIASGYN AELDEWRALA DGATDYLDRL EIREREKLGL DTLKVGFNGV HGYYIQVSRG
     QSHLVPIHYV RRQTLKNAER YIIPELKEYE DKVLTSKGKA LAIEKGLYEE IFDLLLPHLP
     ELQLSANALA ELDVLANLAE RAETLNYSCP TLSDKPGIKI MGGRHPVVEQ VLKEPFISNP
     LTLSPQRRML IITGPNMGGK STYMRQTALI VLLAHLGSYV PADQATIGPI DRIFTRVGAA
     DDLASGRSTF MVEMTETANI LHNATEQSLV LMDEIGRGTS TYDGLSLAWA CAENLASRIK
     AMTLFATHYF ELTTLPEKME GVANVHLDAL EHGETIAFMH SVQEGAASKS YGLAVAALAG
     VPRDVIKRAR QKLKELESLS NNAAASTIDG SQMTLLNEEI PPAVEALEAL DPDSLSPRQA
     LEWIYRLKNM V