ID   MUTS_YERPE              Reviewed;         851 AA.
AC   Q8ZBQ3; Q0WBU1;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=YPO3354, y0835, YP_0333;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AL590842; CAL21943.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM84420.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS60606.1; -; Genomic_DNA.
DR   PIR; AD0407; AD0407.
DR   RefSeq; WP_002209399.1; NZ_WUCM01000065.1.
DR   RefSeq; YP_002348247.1; NC_003143.1.
DR   AlphaFoldDB; Q8ZBQ3; -.
DR   SMR; Q8ZBQ3; -.
DR   IntAct; Q8ZBQ3; 2.
DR   STRING; 214092.YPO3354; -.
DR   PaxDb; Q8ZBQ3; -.
DR   DNASU; 1145782; -.
DR   EnsemblBacteria; AAM84420; AAM84420; y0835.
DR   EnsemblBacteria; AAS60606; AAS60606; YP_0333.
DR   GeneID; 57975355; -.
DR   KEGG; ype:YPO3354; -.
DR   KEGG; ypk:y0835; -.
DR   KEGG; ypm:YP_0333; -.
DR   PATRIC; fig|1028802.3.peg.746; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..851
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115174"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   851 AA;  94814 MW;  09CF67E0FDDE15B1 CRC64;
     MKNNDKLDSH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YSDAKRASQL LDISLTKRGA
     SAGEPIPMAG VPYHSIENYL AKLVQLGESA AICEQIGDPA TSKGPVERKV VRIVTPGTIS
     DEALLQERQD NLLAAIWQDA KGFGYATLDI SSGRFRVAEP ADLETMAAEL QRTNPAELLY
     PENFEPMSLI EHRHGLRRRP LWEFELDTAK QQLNLQFGTR DLIGFGVEQA HLALRAAGCL
     LQYVKDTQRT SLPHIRGLTM ERQQDGIIMD AATRRNLELT QNLSGGSENT LAAILDCSVT
     PMGSRMLKRW LHMPIRDIRV LTDRQQAIGG LQDIAAELQT PLRQVGDLER ILARLALRTA
     RPRDLARMRH AFQQLPEIHR LLQPIDVPHV QNLLSQVGQF DELQDLLERA IVETPPVLVR
     DGGVIASGYN AELDEWRALA DGATDYLDRL EIREREKLGL DTLKVGFNGV HGYYIQVSRG
     QSHLVPIHYV RRQTLKNAER YIIPELKEYE DKVLTSKGKA LAIEKGLYEE IFDLLLPHLP
     ELQLSANALA ELDVLANLAE RAETLNYSCP TLSDKPGIKI MGGRHPVVEQ VLKEPFISNP
     LTLSPQRRML IITGPNMGGK STYMRQTALI VLLAHLGSYV PADQATIGPI DRIFTRVGAA
     DDLASGRSTF MVEMTETANI LHNATEQSLV LMDEIGRGTS TYDGLSLAWA CAENLASRIK
     AMTLFATHYF ELTTLPEKME GVVNVHLDAL EHGETIAFMH SVQEGAASKS YGLAVAALAG
     VPRDVIKRAR QKLKELESLS NNAAASTIDG SQMTLLNEEI PPAVEALEAL DPDSLSPRQA
     LEWIYRLKNM V