ID   MUTS_ZYMMO              Reviewed;         869 AA.
AC   Q5NL79;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ZMO1907;
OS   Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Zymomonadaceae; Zymomonas.
OX   NCBI_TaxID=264203;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RX   PubMed=15592456; DOI=10.1038/nbt1045;
RA   Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H.,
RA   Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J.,
RA   Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y., Kang H.L., Lee S.Y., Lee K.J.,
RA   Kang H.S.;
RT   "The genome sequence of the ethanologenic bacterium Zymomonas mobilis
RT   ZM4.";
RL   Nat. Biotechnol. 23:63-68(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE008692; AAV90531.2; -; Genomic_DNA.
DR   RefSeq; WP_011241632.1; NZ_CP035711.1.
DR   AlphaFoldDB; Q5NL79; -.
DR   SMR; Q5NL79; -.
DR   STRING; 264203.ZMO1907; -.
DR   EnsemblBacteria; AAV90531; AAV90531; ZMO1907.
DR   GeneID; 58027611; -.
DR   KEGG; zmo:ZMO1907; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001173; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..869
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224421"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   869 AA;  94797 MW;  37097613195CAD10 CRC64;
     MMEQYYELKA QAQDCLLFYR MGDFFELFFD DAKKASAILD IALTSRGTHI EESIPMCGVP
     IHAAESYLAR LIKAGCRVAI ADQVETPAEA KKRGGSKALV KRAIIRVVTA GTLTEEALLD
     SRAANWLVAV ARAGSDFGLA AADISTGRFE TIALSEGRLD SELARLSAAE VIAPESLVQQ
     EAYKNRIPQA VELSNECFNS PHGEARLKSI FKISTLDGFG IFSRAELAAI DGLLAWLDRA
     GQGKLPFLQQ PVRRAYADHM LIDAATRSSL ELTASTEGRR DGSLVSSIDH TVTGAGARLL
     TADLGAPLMD IDVIHKRLDL VEFFFYDTLL REDVRDLLKG SPDLARVLGR LVAGRGTPRD
     LSLLRDGLNQ AFILYEKLFS LEHKPALLEQ ILPDFRGHGS LVDLLERALI EQPPIDATQG
     GFIAKGYDHA LDELRSMGGE SRRAIAALEA TYREKTGINT LKIRHNNVLG YHIEVPSRHA
     DALMQANSGF THRQTLAGVV RFNASELHEQ AIRATQAGVQ AIAIESKHLA CLIESTLEKR
     DNIAACADAL ARLDVSAGFA DCAVQKNWTR PTVDDSCCFD VIQGRHPVVE NALVKSGERF
     VANNTNLDPK NRLWLVTGPN MGGKSTFLRQ NALLAVLAQT GSFVPAEKAR IGLVDRLFSR
     VGASDNLARG RSTFMVEMVE TAAILSQATN RSFVILDEVG RGTSTYDGLA IAWAVVEAVH
     DINACRCLFA THYHELTQLT SRLPALSLHH VRAKEWQGDL VLLHEMAEGA ADRSYGIEVA
     RLAGLPPVVL KRASEVLAQL ENSSGKNNDS SANLSDLPLF GVQAFQTVLP QNNPLYDAVS
     ELDADALTPR QALDIIYRLK ELAAKDKVM