MVL_DROME
ID MVL_DROME Reviewed; 596 AA.
AC P49283; Q95TT7; Q9VDF5;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2003, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Protein Malvolio;
GN Name=Mvl; ORFNames=CG3671;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C).
RX PubMed=7621816; DOI=10.1002/j.1460-2075.1995.tb07303.x;
RA Rodrigues V., Cheah P.Y., Ray K., Chia W.;
RT "Malvolio, the Drosophila homologue of mouse NRAMP-1 (Bcg), is expressed in
RT macrophages and in the nervous system and is required for normal taste
RT behaviour.";
RL EMBO J. 14:3007-3020(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Putative transporter required for normal taste behavior. May
CC be a nitrite/nitrate transporter.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A; Synonyms=B;
CC IsoId=P49283-2; Sequence=Displayed;
CC Name=C;
CC IsoId=P49283-1; Sequence=VSP_008202;
CC -!- TISSUE SPECIFICITY: Expressed in macrophages and in the nervous system.
CC -!- MISCELLANEOUS: 'Malvolio' is a character in Shakespeare's twelfth
CC night, who 'taste(d) with distempered appetite'.
CC -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000305}.
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DR EMBL; U23948; AAA82593.1; -; mRNA.
DR EMBL; AE014297; AAF55839.2; -; Genomic_DNA.
DR EMBL; AE014297; AAS65187.1; -; Genomic_DNA.
DR EMBL; AY058543; AAL13772.1; -; mRNA.
DR PIR; S56140; S56140.
DR RefSeq; NP_001163668.1; NM_001170197.1. [P49283-2]
DR RefSeq; NP_524425.2; NM_079701.5. [P49283-2]
DR RefSeq; NP_732584.1; NM_169944.3. [P49283-2]
DR RefSeq; NP_996251.2; NM_206529.2.
DR AlphaFoldDB; P49283; -.
DR SMR; P49283; -.
DR BioGRID; 67461; 2.
DR STRING; 7227.FBpp0297444; -.
DR TCDB; 2.A.55.2.11; the metal ion (mn(2+)-iron) transporter (nramp) family.
DR GlyGen; P49283; 3 sites.
DR PaxDb; P49283; -.
DR DNASU; 42490; -.
DR EnsemblMetazoa; FBtr0089521; FBpp0088507; FBgn0011672. [P49283-2]
DR EnsemblMetazoa; FBtr0301477; FBpp0290692; FBgn0011672. [P49283-2]
DR EnsemblMetazoa; FBtr0301478; FBpp0290693; FBgn0011672. [P49283-2]
DR GeneID; 42490; -.
DR KEGG; dme:Dmel_CG3671; -.
DR UCSC; CG3671-RA; d. melanogaster. [P49283-2]
DR CTD; 42490; -.
DR FlyBase; FBgn0011672; Mvl.
DR VEuPathDB; VectorBase:FBgn0011672; -.
DR eggNOG; KOG1291; Eukaryota.
DR GeneTree; ENSGT00940000170016; -.
DR HOGENOM; CLU_020088_5_2_1; -.
DR InParanoid; P49283; -.
DR OMA; IATFVNS; -.
DR PhylomeDB; P49283; -.
DR Reactome; R-DME-1222556; ROS and RNS production in phagocytes.
DR Reactome; R-DME-425410; Metal ion SLC transporters.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR Reactome; R-DME-6803544; Ion influx/efflux at host-pathogen interface.
DR Reactome; R-DME-917937; Iron uptake and transport.
DR BioGRID-ORCS; 42490; 2 hits in 3 CRISPR screens.
DR GenomeRNAi; 42490; -.
DR PRO; PR:P49283; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0011672; Expressed in embryonic/larval hemocyte (Drosophila) and 27 other tissues.
DR ExpressionAtlas; P49283; baseline and differential.
DR Genevisible; P49283; DM.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IDA:FlyBase.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:FlyBase.
DR GO; GO:0016020; C:membrane; IDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IMP:FlyBase.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IMP:FlyBase.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IMP:FlyBase.
DR GO; GO:0015293; F:symporter activity; IGI:FlyBase.
DR GO; GO:0055070; P:copper ion homeostasis; IMP:FlyBase.
DR GO; GO:0015677; P:copper ion import; IMP:FlyBase.
DR GO; GO:0055072; P:iron ion homeostasis; IMP:FlyBase.
DR GO; GO:0034755; P:iron ion transmembrane transport; IMP:FlyBase.
DR GO; GO:0055071; P:manganese ion homeostasis; IBA:GO_Central.
DR GO; GO:0030001; P:metal ion transport; IGI:FlyBase.
DR GO; GO:0034761; P:positive regulation of iron ion transmembrane transport; IMP:FlyBase.
DR GO; GO:0010042; P:response to manganese ion; IBA:GO_Central.
DR GO; GO:0050916; P:sensory perception of sweet taste; IMP:FlyBase.
DR GO; GO:0055076; P:transition metal ion homeostasis; IMP:FlyBase.
DR GO; GO:0000041; P:transition metal ion transport; IMP:FlyBase.
DR GO; GO:0046718; P:viral entry into host cell; IMP:FlyBase.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..596
FT /note="Protein Malvolio"
FT /id="PRO_0000212597"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 520..540
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 359
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 574
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 487..596
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000303|PubMed:7621816"
FT /id="VSP_008202"
SQ SEQUENCE 596 AA; 65466 MW; 1128C4A7795C2F9E CRC64;
MSSNEAYHEP GAGGDGPGGS SGASGGGSQR SNQLHHQQIL NETTYLKPAA KQAYFSDEKV
LIPDDDSTNV GFSFRKLWAF TGPGFLMSIA YLDPGNIESD MQSGAAAKYK ILWVLLWATV
LGLLMQRLAA RLGVVTGLHL AEMCYRQYKR LPRWILWIMI EIAIIGSDMQ EVIGTAIAIY
LLSNKVVPLW GGVLITIVDT FTFLFLDKYG LRKLEFLFGT LITIMAVSFG YEYIVSAPNQ
GEVLEGMFVP WCSNCNSNVL LQAVGVVGAV IMPHNLYLHS ALVKSRDIDR RQTKKVSEAN
FYFFIEASVA LFVSFIINLF VVAVFAHGMY GKTNNDVVEV CKDKSMYEDA KMSFVDNVNG
TAIIDADLYK GGLFLGCTFG AVAMYIWGVG ILAAGQSSTM TGTYAGQFSM EGFLNLQWPR
WCRVLVTRCI AIIPTFCLAM FSKMEDLTSM NDILNAVMSL QLPFAAIPTI AFTSCAAIMG
EFVNGLGNKI VSILLTIVVI GVNLYFVVVQ VENMEIKGGL LALVCIFAIL YILFNLYLVI
HMAACMGNQR LMNSRWVQRF VLPSQNSFSI KNANSTYARI ATSSDQEPEG LAGEDA
