MVP1_SCHPO
ID MVP1_SCHPO Reviewed; 664 AA.
AC O14120;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 3.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Sorting nexin mvp1;
GN Name=mvp1; ORFNames=SPAC3A11.06;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for vacuolar protein sorting. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- DOMAIN: The PX domain binds phosphatidylinositol 3-phosphate which is
CC necessary for peripheral membrane localization. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR EMBL; CU329670; CAB16392.2; -; Genomic_DNA.
DR PIR; T11628; T11628.
DR RefSeq; NP_594197.1; NM_001019621.2.
DR AlphaFoldDB; O14120; -.
DR SMR; O14120; -.
DR BioGRID; 279556; 17.
DR STRING; 4896.SPAC3A11.06.1; -.
DR iPTMnet; O14120; -.
DR MaxQB; O14120; -.
DR PaxDb; O14120; -.
DR PRIDE; O14120; -.
DR EnsemblFungi; SPAC3A11.06.1; SPAC3A11.06.1:pep; SPAC3A11.06.
DR GeneID; 2543124; -.
DR KEGG; spo:SPAC3A11.06; -.
DR PomBase; SPAC3A11.06; mvp1.
DR VEuPathDB; FungiDB:SPAC3A11.06; -.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_413408_0_0_1; -.
DR InParanoid; O14120; -.
DR OMA; QNSFNCL; -.
DR PhylomeDB; O14120; -.
DR PRO; PR:O14120; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0000329; C:fungal-type vacuole membrane; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISO:PomBase.
DR GO; GO:0097749; P:membrane tubulation; ISO:PomBase.
DR GO; GO:0006623; P:protein targeting to vacuole; ISO:PomBase.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISO:PomBase.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR47554; PTHR47554; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Membrane; Protein transport; Reference proteome; Transport.
FT CHAIN 1..664
FT /note="Sorting nexin mvp1"
FT /id="PRO_0000238601"
FT DOMAIN 279..395
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT REGION 221..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 320
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
FT BINDING 322
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
FT BINDING 346
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
SQ SEQUENCE 664 AA; 76861 MW; FB4E9F1C312FA85C CRC64;
MGDNVFLEPD PWASSSNWGS PVKPLNYKTA IGNSSIPLQY RNYWDVFQAN NVLLFPEEES
YSDIFHVPQD VMKEFFTLIE SSSNQPLRQI QFFVLLALVA CYQLGVPSTL EQIFKQRNVL
PILQRFNPEL FNRSSDNETP LFPNNSPPAS TTALNLSSNI VPSINESKIL EQEDDDVSNK
SLPHAQQSII RSFPDIQKQP KGFFSYPSST VSSIAPSTLE AGNLHSQQPP KFSVDSSVDD
NAITPRKPFS KIPNRLSPST QPLLSNSRHS SFRLASSSTS FPASLEMNVD IDLEPSGYFF
YRHNNYIISD SSNTREVLRR YSDFFWLHSY LMKKYPFRRV PLIPLKKFHS KCFNSKQFFR
TPPPGLSDFV NDLSHHPIFS NDEVVRVFFT EPNVFKNWRR ENQKRIDQEI EQFLVVPQSQ
VPDASETVKE RLLKLNMSTT TAINNQLNIF RIFEKMIFTL QHFHEDFLRL QNSFNCLLDS
GLYHQVFTST FAQNESKIMS MASGHFYNID SLLHQQNDAV KHTFLLGLSK EIKILISLRL
LIERISEVFS TDLTKVRHTI SNDENLLRET ANSDESGRNR TFLNRSSKKR AENSLKSKKE
LYLKNLNQRY QIAHELEQEL SYLQDYVFSL GNPYVEYCKQ HVKLEEESLK IWHTLESDFS
RLET
