ID   MVP_BBTVA               Reviewed;         117 AA.
AC   Q65387;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-JUN-2021, entry version 50.
DE   RecName: Full=Movement and RNA silencing protein;
DE            Short=MP;
GN   Name=DNA-M; Synonyms=C4;
OS   Banana bunchy top virus (isolate Autralia) (BBTV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Arfiviricetes;
OC   Mulpavirales; Nanoviridae; Babuvirus.
OX   NCBI_TaxID=645099;
OH   NCBI_TaxID=4640; Musa.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7782775; DOI=10.1099/0022-1317-76-6-1471;
RA   Burns T.M., Harding R.M., Dale J.L.;
RT   "The genome organization of banana bunchy top virus: analysis of six ssDNA
RT   components.";
RL   J. Gen. Virol. 76:1471-1482(1995).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=10640570; DOI=10.1099/0022-1317-81-1-299;
RA   Wanitchakorn R., Hafner G.J., Harding R.M., Dale J.L.;
RT   "Functional analysis of proteins encoded by banana bunchy top virus DNA-4
RT   to -6.";
RL   J. Gen. Virol. 81:299-306(2000).
RN   [3]
RP   FUNCTION.
RX   PubMed=19816653; DOI=10.1007/s00705-009-0515-5;
RA   Niu S., Wang B., Guo X., Yu J., Wang X., Xu K., Zhai Y., Wang J., Liu Z.;
RT   "Identification of two RNA silencing suppressors from banana bunchy top
RT   virus.";
RL   Arch. Virol. 154:1775-1783(2009).
CC   -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC       through plasmosdesmata, without any budding. The movement protein
CC       allows efficient cell to cell propagation, by bypassing the host cell
CC       wall barrier. Begomovirus genome is shuttled out of nucleus by Nuclear
CC       shuttle protein (NSP) and the movement protein transports the DNA-NSP
CC       complex to cell plasmodesmata and facilitates further movement across
CC       the cell wall. Acts as a suppressor of RNA-mediated gene silencing,
CC       also known as post-transcriptional gene silencing (PTGS), a mechanism
CC       of plant viral defense that limits the accumulation of viral RNAs.
CC       {ECO:0000269|PubMed:19816653}.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Note=The hydrophobic region is
CC       responsible for the localization of the protein to the cell periphery.
CC       {ECO:0000269|PubMed:10640570}.
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DR   EMBL; L41575; AAA87369.1; -; Genomic_DNA.
DR   RefSeq; NP_604478.1; NC_003474.1.
DR   SMR; Q65387; -.
DR   GeneID; 963868; -.
DR   KEGG; vg:963868; -.
DR   Proteomes; UP000002339; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR009871; MP.
DR   Pfam; PF07234; Babuvirus_MP; 1.
PE   4: Predicted;
KW   Host cell membrane; Host membrane; Membrane; Reference proteome;
KW   Suppressor of RNA silencing; Transmembrane; Transmembrane helix; Transport;
KW   Viral movement protein.
FT   CHAIN           1..117
FT                   /note="Movement and RNA silencing protein"
FT                   /id="PRO_0000378541"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          83..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   117 AA;  13739 MW;  EE1EA08FC63590A7 CRC64;
     MALTTERVKL FFEWFLFFGA IFIAITILYI LLVLLFEVPR YIKELVRCLV EYLTRRRVWM
     QRTQLTEATG DVEIGRGIVE DRRDQEPAVI PHVSQVIPSQ PNRRDDQGRR GNAGPMF