ID   MVP_BMV                 Reviewed;         303 AA.
AC   P03603;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Movement protein;
DE            Short=MP;
DE   AltName: Full=Protein 3A;
GN   ORFNames=ORF3a;
OS   Brome mosaic virus (BMV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Martellivirales; Bromoviridae; Bromovirus.
OX   NCBI_TaxID=12302;
OH   NCBI_TaxID=15371; Bromus inermis (Smooth brome grass) (Bromopsis inermis).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7338913; DOI=10.1016/0022-2836(81)90524-6;
RA   Ahlquist P., Luckow V., Kaesberg P.;
RT   "Complete nucleotide sequence of brome mosaic virus RNA3.";
RL   J. Mol. Biol. 153:23-38(1981).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=9267012; DOI=10.1099/0022-1317-78-8-2089;
RA   Kasteel D.T., van der Wel N.N., Jansen K.A., Goldbach R.W., van Lent J.W.;
RT   "Tubule-forming capacity of the movement proteins of alfalfa mosaic virus
RT   and brome mosaic virus.";
RL   J. Gen. Virol. 78:2089-2093(1997).
RN   [3]
RP   PHOSPHORYLATION BY HOST.
RX   PubMed=17680322; DOI=10.1007/s00705-007-1038-6;
RA   Akamatsu N., Takeda A., Kishimoto M., Kaido M., Okuno T., Mise K.;
RT   "Phosphorylation and interaction of the movement and coat proteins of brome
RT   mosaic virus in infected barley protoplasts.";
RL   Arch. Virol. 152:2087-2093(2007).
CC   -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC       through plasmosdesmata, without any budding. The movement protein
CC       allows efficient cell to cell propagation, by bypassing the host cell
CC       wall barrier. Acts by forming a tubular structure at the host
CC       plasmodesmata, enlarging it enough to allow free passage of virion
CC       capsids.
CC   -!- SUBCELLULAR LOCATION: Host cell junction, host plasmodesma
CC       {ECO:0000269|PubMed:9267012}. Note=Assembles into long tubular
CC       structures at the surface of the infected protoplast.
CC   -!- PTM: Phosphorylated by host. {ECO:0000269|PubMed:17680322}.
CC   -!- SIMILARITY: Belongs to the bromovirus movement protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; J02042; AAA46333.1; -; Genomic_RNA.
DR   PIR; A04214; P3BVAM.
DR   RefSeq; NP_041198.1; NC_002028.2.
DR   GeneID; 962147; -.
DR   KEGG; vg:962147; -.
DR   Proteomes; UP000001649; Genome.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR000603; MPV.
DR   Pfam; PF00803; 3A; 1.
PE   1: Evidence at protein level;
KW   Host cell junction; Reference proteome; Transport; Viral movement protein.
FT   CHAIN           1..303
FT                   /note="Movement protein"
FT                   /id="PRO_0000083231"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   303 AA;  32482 MW;  F66B93BC58372D37 CRC64;
     MSNIVSPFSG SSRTTSDVGK QAGGTSDEKL IESLFSEKAV KEIAAECKLG CYNYLKSNEP
     RNYIDLVPKS HVSAWLSWAT SKYDKGELPS RGFMNVPRIV CFLVRTTDSA ESGSITVSLC
     DSGKAARAGV LEAIDNQEAT IQLSALPALI ALTPSYDCPM EVIGGDSGRN RCFGIATQLS
     GVVGTTGSVA VTHAYWQANF KAKPNNYKLH GPATIMVMPF DRLRQLDKKS LKNYIRGISN
     QSVDHGYLLG RPLQSVDQVA QEDLLVEESE SPSALGRGVK DSKSVSASSV AGLPVSSPTL
     RIK