ID   MVP_CAMVC               Reviewed;         327 AA.
AC   P03546;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Movement protein;
DE            Short=Mov;
DE   AltName: Full=Cell-to-cell transport protein;
GN   ORFNames=ORF I;
OS   Cauliflower mosaic virus (strain CM-1841) (CaMV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Caulimoviridae; Caulimovirus.
OX   NCBI_TaxID=10644;
OH   NCBI_TaxID=3702; Arabidopsis thaliana (Mouse-ear cress).
OH   NCBI_TaxID=3705; Brassica.
OH   NCBI_TaxID=3725; Raphanus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6269062; DOI=10.1093/nar/9.12.2871;
RA   Gardner R.C., Howarth A.J., Hahn P., Brown-Luedi M., Shepherd R.J.,
RA   Messing J.;
RT   "The complete nucleotide sequence of an infectious clone of cauliflower
RT   mosaic virus by M13mp7 shotgun sequencing.";
RL   Nucleic Acids Res. 9:2871-2888(1981).
RN   [2]
RP   INTERACTION WITH HOST PRA1D.
RX   PubMed=11725951; DOI=10.1023/a:1012491913431;
RA   Huang Z., Andrianov V.M., Han Y., Howell S.H.;
RT   "Identification of arabidopsis proteins that interact with the cauliflower
RT   mosaic virus (CaMV) movement protein.";
RL   Plant Mol. Biol. 47:663-675(2001).
CC   -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC       through plasmosdesmata, without any budding. The movement protein
CC       allows efficient cell to cell propagation, by bypassing the host cell
CC       wall barrier. Acts by forming tubules structures that increase the size
CC       exclusion limit (SEL) of plasmodesmata, thereby allowing viral
CC       ribonucleocapsids to spread directly to neighboring cells (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer, through the coiled-coil domain (By similarity).
CC       Interacts with VAP (By similarity). May interact (via N-terminus) with
CC       host prenylated Rab acceptor protein 1D (PRA1D). {ECO:0000250,
CC       ECO:0000269|PubMed:11725951}.
CC   -!- SUBCELLULAR LOCATION: Host cell junction, host plasmodesma.
CC       Note=Assembles in tubules that are embedded within modified
CC       plasmodesmata.
CC   -!- SIMILARITY: Belongs to the caulimoviridae movement protein family.
CC       {ECO:0000305}.
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DR   EMBL; V00140; CAA23452.1; -; Genomic_DNA.
DR   Proteomes; UP000008438; Genome.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR028919; Viral_movement.
DR   Pfam; PF01107; MP; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Host cell junction; Host-virus interaction;
KW   Reference proteome; Transport; Viral movement protein.
FT   CHAIN           1..327
FT                   /note="Movement protein"
FT                   /id="PRO_0000222058"
FT   COILED          297..327
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   327 AA;  36872 MW;  8B3F4D9A428785B2 CRC64;
     MDLYPEENTQ SEQSQNSENN MQIFKSENSD GFSSDLMISN DQLKNISKTQ LTLEKEKIFK
     MPNVLSQVMK KAFSRKNEIL YCVSTKELSV DIHDATGKVY LPLITREEIN KRLSSLKPEV
     RKIMSMVHLG AVKILLKAQF RNGIDTPIKI ALIDDRINSR RDCLLGAAKG NLAYGKFMFT
     VYPKFGISLN TQRLNQTLSL IHDFENKNLM NKGDKVMTIT YIVGYALTNS HHSIDYQSNA
     TIELEDVFQE IGNVQQSDFC TIQNDECNWA IDIAQNKALL GAKTQSQIGN SLQIGNSASS
     SNTENELARV SQNIDLLKNK LKEICGE