ID   MVP_CAMVS               Reviewed;         327 AA.
AC   P03545;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   07-OCT-2020, entry version 68.
DE   RecName: Full=Movement protein;
DE            Short=MP;
DE   AltName: Full=Cell-to-cell transport protein;
GN   ORFNames=ORF I;
OS   Cauliflower mosaic virus (strain Strasbourg) (CaMV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Caulimoviridae; Caulimovirus.
OX   NCBI_TaxID=10648;
OH   NCBI_TaxID=3702; Arabidopsis thaliana (Mouse-ear cress).
OH   NCBI_TaxID=3705; Brassica.
OH   NCBI_TaxID=3725; Raphanus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7407912; DOI=10.1016/0092-8674(80)90136-1;
RA   Franck A., Guilley H., Jonard G., Richards K., Hirth L.;
RT   "Nucleotide sequence of cauliflower mosaic virus DNA.";
RL   Cell 21:285-294(1980).
RN   [2]
RP   INTERACTION WITH HOST PRA1D.
RC   STRAIN=CM-1841;
RX   PubMed=11725951; DOI=10.1023/a:1012491913431;
RA   Huang Z., Andrianov V.M., Han Y., Howell S.H.;
RT   "Identification of arabidopsis proteins that interact with the cauliflower
RT   mosaic virus (CaMV) movement protein.";
RL   Plant Mol. Biol. 47:663-675(2001).
RN   [3]
RP   HOMOTRIMER, INTERACTION WITH VAP, SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=15837934; DOI=10.1073/pnas.0407731102;
RA   Stavolone L., Villani M.E., Leclerc D., Hohn T.;
RT   "A coiled-coil interaction mediates cauliflower mosaic virus cell-to-cell
RT   movement.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:6219-6224(2005).
CC   -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC       through plasmosdesmata, without any budding. The movement protein
CC       allows efficient cell to cell propagation, by bypassing the host cell
CC       wall barrier. Acts by forming tubules structures that increase the size
CC       exclusion limit (SEL) of plasmodesmata, thereby allowing viral
CC       ribonucleocapsids to spread directly to neighboring cells.
CC       {ECO:0000269|PubMed:15837934}.
CC   -!- SUBUNIT: Homotrimer, through the coiled-coil domain. Interacts with
CC       VAP. May interact (via N-terminus) with host prenylated Rab acceptor
CC       protein 1D (PRA1D). {ECO:0000269|PubMed:11725951,
CC       ECO:0000269|PubMed:15837934}.
CC   -!- SUBCELLULAR LOCATION: Host cell junction, host plasmodesma
CC       {ECO:0000269|PubMed:15837934}. Note=Assembles in tubules that are
CC       embedded within modified plasmodesmata.
CC   -!- SIMILARITY: Belongs to the caulimoviridae movement protein family.
CC       {ECO:0000305}.
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DR   EMBL; V00141; CAA23456.1; -; Genomic_DNA.
DR   PIR; B90799; QQCV1.
DR   RefSeq; NP_056724.1; NC_001497.1.
DR   GeneID; 1489544; -.
DR   KEGG; vg:1489544; -.
DR   Proteomes; UP000002501; Genome.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR028919; Viral_movement.
DR   Pfam; PF01107; MP; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Host cell junction; Host-virus interaction;
KW   Reference proteome; Transport; Viral movement protein.
FT   CHAIN           1..327
FT                   /note="Movement protein"
FT                   /id="PRO_0000222062"
FT   COILED          297..327
SQ   SEQUENCE   327 AA;  36873 MW;  84C8CF2598BD0967 CRC64;
     MDLYPEENTQ SEQSQNSENN MQIFKSENSD GFSSDLMISN DQLKNISKTQ LTLEKEKIFK
     MPNVLSQVMK KAFSRKNEIL YCVSTKELSV DIHDATGKVY LPLITKEEIN KRLSSLKPEV
     RKTMSMVHLG AVKILLKAQF RNGIDTPIKI ALIDDRINSR RDCLLGAAKG NLAYGKFMFT
     VYPKFGISLN TQRLNQTLSL IHDFENKNLM NKGDKVMTIT YVVGYALTNS HHSIDYQSNA
     TIELEDVFQE IGNVQQSEFC TIQNDECNWA IDIAQNKALL GAKTKTQIGN NLQIGNSASS
     SNTENELARV SQNIDLLKNK LKEICGE