ID   MVP_CHICK               Reviewed;         849 AA.
AC   Q5ZMI4;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Major vault protein;
DE            Short=MVP;
GN   Name=MVP; ORFNames=RCJMB04_1p8;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Required for normal vault structure. Vaults are multi-subunit
CC       structures that may act as scaffolds for proteins involved in signal
CC       transduction. Vaults may also play a role in nucleo-cytoplasmic
CC       transport (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The vault ribonucleoprotein particle is a huge (400 A x 670 A)
CC       cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with
CC       each half-vault comprising 39 identical major vault protein (MVP)
CC       chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14764}. Nucleus
CC       {ECO:0000250|UniProtKB:Q14764}.
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DR   EMBL; AJ719400; CAG31059.1; -; mRNA.
DR   RefSeq; NP_001006336.1; NM_001006336.1.
DR   AlphaFoldDB; Q5ZMI4; -.
DR   SMR; Q5ZMI4; -.
DR   STRING; 9031.ENSGALP00000000316; -.
DR   PRIDE; Q5ZMI4; -.
DR   GeneID; 420049; -.
DR   KEGG; gga:420049; -.
DR   CTD; 9961; -.
DR   VEuPathDB; HostDB:geneid_420049; -.
DR   eggNOG; ENOG502QPP0; Eukaryota.
DR   InParanoid; Q5ZMI4; -.
DR   OrthoDB; 256008at2759; -.
DR   PhylomeDB; Q5ZMI4; -.
DR   PRO; PR:Q5ZMI4; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   CDD; cd08825; MVP_shoulder; 1.
DR   Gene3D; 2.30.30.550; -; 4.
DR   Gene3D; 2.30.30.560; -; 2.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR039059; MVP.
DR   InterPro; IPR041139; MVP_rep_dom.
DR   InterPro; IPR043023; MVP_rep_sf.
DR   InterPro; IPR021870; MVP_shoulder.
DR   InterPro; IPR041134; Vault_2.
DR   InterPro; IPR043179; Vault_2_sf.
DR   InterPro; IPR040989; Vault_3.
DR   InterPro; IPR041136; Vault_4.
DR   InterPro; IPR002499; Vault_N.
DR   PANTHER; PTHR14165; PTHR14165; 1.
DR   Pfam; PF11978; MVP_shoulder; 1.
DR   Pfam; PF01505; Vault; 4.
DR   Pfam; PF17794; Vault_2; 2.
DR   Pfam; PF17795; Vault_3; 1.
DR   Pfam; PF17796; Vault_4; 1.
DR   PROSITE; PS51224; MVP; 8.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; Ribonucleoprotein.
FT   CHAIN           1..849
FT                   /note="Major vault protein"
FT                   /id="PRO_0000247489"
FT   REPEAT          2..54
FT                   /note="MVP 1"
FT   REPEAT          55..109
FT                   /note="MVP 2"
FT   REPEAT          110..162
FT                   /note="MVP 3"
FT   REPEAT          163..215
FT                   /note="MVP 4"
FT   REPEAT          216..270
FT                   /note="MVP 5"
FT   REPEAT          271..321
FT                   /note="MVP 6"
FT   REPEAT          322..378
FT                   /note="MVP 7"
FT   REPEAT          379..458
FT                   /note="MVP 8"
FT   REPEAT          459..521
FT                   /note="MVP 9"
SQ   SEQUENCE   849 AA;  93822 MW;  299ABAC7F818170A CRC64;
     MEDPVIRIPP YHYIHVLDLN SNVTRVEVGP HSFIRQDHER VVFSPKRMVM VPPRHYCVVL
     NPVARGPTGA VLFDGAGQAQ LRHADLDIRL TQEPFPLYPG EELQQGVTPL QVVLADTALR
     LRALLDFEDE DGNKFVAGDE WLFEGPGTYI PHKEVEVVET LQATIIRHNQ AIRLRARKEC
     LDRQGTRRVT GEEWLVKRVG AYLPGVYEEV VDVVDAYVLT DKKALHLRAT RTFEDVQGHV
     RRTGEEWLVT QEQSEAYVPD VFEEVVAEVL VTTLGPRQYC VVLDPVGPNG QPQLGQQRVV
     KGEKSFFLQP GERLQAGIQD VYVLSEDEGL LLQALQTIKD TDEDGTEVIR RAGDRWLARG
     PLEYVPPAEV TVLERRQALA LAENEGIYVR DIRTGKVRVV TGQTYMLTES EELWEKELPP
     GVEVLLAEAR GDTAGQDSGI QSSSGPSFGV QERDRTRAVT YQVPHNAAVQ VYDYRERRAR
     VVLGPELVVL GPGEQLTVLS LSGGRPKRPH ARRSLCLRLG PDFCADIVTI ETADHARLQL
     QLAYNWHFEV PEDPKALGRL FSVPDFVGDA CKALASRVRG AVAAVTFDDF HKNSNRLICS
     AVFGFDEGGR LREHLRFVPN GLVVTSVDIQ SVEPVDQRTR DALQRSVQLA IEIATNSQEA
     AARHEAERLA QEARVRLERQ RLLDQAEAER ARRELLELEA LSAAVESAGA ARAEAQARAE
     AARIEAEAAI LQAKLKAEAV AIETEAELAR LERMQAQEVR AQRARAEAEA ARAQALAAVE
     ASKVREVAAA LGPETIRDIA RAGPELQVKL LQGLGLQSAL ITDGAAPLNL FSTARGLLGL
     AVPPEPSTS