MVP_DANRE
ID MVP_DANRE Reviewed; 863 AA.
AC Q6P3L0; Q7ZUB4;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Major vault protein;
DE Short=MVP;
GN Name=mvp;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for normal vault structure. Vaults are multi-subunit
CC structures that may act as scaffolds for proteins involved in signal
CC transduction. Vaults may also play a role in nucleo-cytoplasmic
CC transport (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The vault ribonucleoprotein particle is a huge (400 A x 670 A)
CC cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with
CC each half-vault comprising 39 identical major vault protein (MVP)
CC chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14764}. Nucleus
CC {ECO:0000250|UniProtKB:Q14764}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P3L0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P3L0-2; Sequence=VSP_019981;
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DR EMBL; BC049344; AAH49344.1; -; mRNA.
DR EMBL; BC063949; AAH63949.1; -; mRNA.
DR RefSeq; NP_958482.1; NM_201325.1. [Q6P3L0-1]
DR AlphaFoldDB; Q6P3L0; -.
DR SMR; Q6P3L0; -.
DR STRING; 7955.ENSDARP00000112736; -.
DR PaxDb; Q6P3L0; -.
DR GeneID; 373081; -.
DR KEGG; dre:373081; -.
DR CTD; 9961; -.
DR ZFIN; ZDB-GENE-030826-33; mvp.
DR eggNOG; ENOG502QPP0; Eukaryota.
DR InParanoid; Q6P3L0; -.
DR PhylomeDB; Q6P3L0; -.
DR Reactome; R-DRE-6798695; Neutrophil degranulation.
DR PRO; PR:Q6P3L0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IMP:ZFIN.
DR GO; GO:0001654; P:eye development; IMP:ZFIN.
DR GO; GO:0031102; P:neuron projection regeneration; IMP:ZFIN.
DR CDD; cd08825; MVP_shoulder; 1.
DR Gene3D; 2.30.30.550; -; 4.
DR Gene3D; 2.30.30.560; -; 2.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR039059; MVP.
DR InterPro; IPR041139; MVP_rep_dom.
DR InterPro; IPR043023; MVP_rep_sf.
DR InterPro; IPR021870; MVP_shoulder.
DR InterPro; IPR041134; Vault_2.
DR InterPro; IPR043179; Vault_2_sf.
DR InterPro; IPR040989; Vault_3.
DR InterPro; IPR041136; Vault_4.
DR InterPro; IPR002499; Vault_N.
DR PANTHER; PTHR14165; PTHR14165; 1.
DR Pfam; PF11978; MVP_shoulder; 1.
DR Pfam; PF01505; Vault; 4.
DR Pfam; PF17794; Vault_2; 2.
DR Pfam; PF17795; Vault_3; 1.
DR Pfam; PF17796; Vault_4; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51224; MVP; 8.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW Ribonucleoprotein.
FT CHAIN 1..863
FT /note="Major vault protein"
FT /id="PRO_0000247490"
FT REPEAT 2..60
FT /note="MVP 1"
FT REPEAT 61..115
FT /note="MVP 2"
FT REPEAT 116..168
FT /note="MVP 3"
FT REPEAT 169..221
FT /note="MVP 4"
FT REPEAT 222..276
FT /note="MVP 5"
FT REPEAT 277..327
FT /note="MVP 6"
FT REPEAT 328..396
FT /note="MVP 7"
FT REPEAT 397..471
FT /note="MVP 8"
FT REPEAT 472..534
FT /note="MVP 9"
FT DOMAIN 677..706
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 349..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 710..735
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_019981"
FT CONFLICT 2
FT /note="D -> E (in Ref. 1; AAH49344)"
FT /evidence="ECO:0000305"
FT CONFLICT 349
FT /note="G -> GQ (in Ref. 1; AAH49344)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 863 AA; 96529 MW; 70740189DF50DC68 CRC64;
MDADHLLGAS IIRIPPHHYI HVLDQNTNIA RVEIGPLTYI RQDNERVLFA PVRMMMVPPR
HYCVVLNPAV RDDEGQVQFD GSGQVKLRHA DLEIRLAQDP FPLYPGEEIQ KDVTPLQIVY
PDTALRLQAL LDFEEEGGEK RVAGDEWLFE GPGTYIPRKE VTVLEVIKAT VIRENQAIRL
RARKEGLDRS GVQRVTGEEW QVSKVGAYLP GAHEEVVDIV SAFILTDKKA LHVRAIRPFR
DAGGRDRRTG EEWLVTVADR EAHIPSVAEE VVGVVDVTTL NSRQYCVIMD PVGADGKPQL
GQKRVVKGER SFFLMPGEHL ENGIQDVYVL SEEEGLVLRA VEAFIDTQGD EAEEEERESR
AKKRGVQRRP GDRWMLRGPI EYVPPATVEV LLTRTAIPLD ENEGIYVRDI KTGKVRAVIG
QTYMLTQDEE LWEKELPANV ESLLAQSRDP LADRSDRGRS FGQAERDKTR VVSYRIPHNA
TVQVYDYREK KARVMFGPEM VMLGPDEQFT VLSLSGDKPK RPNVIKTICL LLGPDFCTDI
ITIETADHAR LQLQLSYNWH FDLKQPADAA QAAALFSVPD FVGDACKAIA SRIRGAVASV
QFDDFHKNSN RIICSAVFGF DEKLAVRSSL RFGQNGLVIS SVDIQSVEPV DQRTRDALQK
SVQLAIEITT NSQEAAARHE AERLEQEARG RLERQKITDQ AEAEKARKEL LELEAQSAAV
ESTGAAKAEA QSRAEAARIQ GEAAVEEAKL KAEAQKIEAD SELARLCKAR EQELNYKKQI
DHLEVEKQQK LADIESQRFK HLMDNLGTET LKEMARAGPE LQVKLLQSLG LKSTLITDGS
SPINLFTTAN GLLGSLQGKD KDE
