ID   MVP_DIPOM               Reviewed;         852 AA.
AC   Q90405;
DT   05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Major vault protein;
DE   AltName: Full=MVP100;
DE            Short=P100;
GN   Name=MVP;
OS   Diplobatis ommata (Ocellated electric ray) (Discopyge ommata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Batoidea; Torpediniformes; Narcinidae; Diplobatis.
OX   NCBI_TaxID=1870830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Electric lobe;
RX   PubMed=8662815; DOI=10.1074/jbc.271.23.13908;
RA   Herrmann C., Volknandt W., Wittich B., Kellner R., Zimmermann H.;
RT   "The major vault protein (MVP100) is contained in cholinergic nerve
RT   terminals of electric ray electric organ.";
RL   J. Biol. Chem. 271:13908-13915(1996).
CC   -!- FUNCTION: Required for normal vault structure. Vaults are multi-subunit
CC       structures that may act as scaffolds for proteins involved in signal
CC       transduction. Vaults may also play a role in nucleo-cytoplasmic
CC       transport (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The vault ribonucleoprotein particle is a huge (400 A x 670 A)
CC       cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with
CC       each half-vault comprising 39 identical major vault protein (MVP)
CC       chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14764}. Nucleus
CC       {ECO:0000250|UniProtKB:Q14764}.
CC   -!- TISSUE SPECIFICITY: Expression is highest in brain and enriched in the
CC       electric lobe. Closely associated with synaptic vesicles in the nerve
CC       terminals of the electric organ. {ECO:0000269|PubMed:8662815}.
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DR   EMBL; X87771; CAA61041.1; -; mRNA.
DR   AlphaFoldDB; Q90405; -.
DR   SMR; Q90405; -.
DR   PRIDE; Q90405; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd08825; MVP_shoulder; 1.
DR   Gene3D; 2.30.30.550; -; 4.
DR   Gene3D; 2.30.30.560; -; 2.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR039059; MVP.
DR   InterPro; IPR041139; MVP_rep_dom.
DR   InterPro; IPR043023; MVP_rep_sf.
DR   InterPro; IPR021870; MVP_shoulder.
DR   InterPro; IPR041134; Vault_2.
DR   InterPro; IPR043179; Vault_2_sf.
DR   InterPro; IPR040989; Vault_3.
DR   InterPro; IPR041136; Vault_4.
DR   InterPro; IPR002499; Vault_N.
DR   PANTHER; PTHR14165; PTHR14165; 1.
DR   Pfam; PF11978; MVP_shoulder; 1.
DR   Pfam; PF01505; Vault; 4.
DR   Pfam; PF17794; Vault_2; 2.
DR   Pfam; PF17795; Vault_3; 1.
DR   Pfam; PF17796; Vault_4; 1.
DR   PROSITE; PS51224; MVP; 8.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Repeat; Ribonucleoprotein.
FT   CHAIN           1..852
FT                   /note="Major vault protein"
FT                   /id="PRO_0000158984"
FT   REPEAT          2..54
FT                   /note="MVP 1"
FT   REPEAT          55..109
FT                   /note="MVP 2"
FT   REPEAT          110..161
FT                   /note="MVP 3"
FT   REPEAT          162..214
FT                   /note="MVP 4"
FT   REPEAT          215..269
FT                   /note="MVP 5"
FT   REPEAT          270..320
FT                   /note="MVP 6"
FT   REPEAT          321..377
FT                   /note="MVP 7"
FT   REPEAT          378..457
FT                   /note="MVP 8"
FT   REPEAT          458..520
FT                   /note="MVP 9"
SQ   SEQUENCE   852 AA;  95832 MW;  C3F25BBE9DC57099 CRC64;
     MEDSIIRIAP YHYIHVLDQN TNVARIENGP KTYIRQDNER VLFPPERMVT IPPRHYCVVA
     NPVVRDREGM PVCDGFGQAR LRHGDREVRL SQDPFPLYPG EELGQVATAL QVVKTNSALH
     LQAQLDFEDH GEKRVAGDEW LFEGPGTYIP RTEVVMICWI NAIVIRHNQG LRLRARKDTR
     DRDGRDRVTG EEWMVRRVGA YLPGVYEEVL DVVNAFILTE KRALHLRALQ TVKDMRDRVR
     RTGEEWLVTL AEAEAYVPGV EEEVVGQVEV TTLGTRQYCV VLDPVGADGK PQLGQKLVVK
     GEKSFFLQPG EHLEAGIQDT YVLSEEEGLV LRAVEAFEEK DEAGKVHCRK PGDRWMIRGP
     VEYVPPVTVE VLSYRHAIPL DQNEGIYVRD LKSGKVRAVI GESYMLSQDE ELWEKTLPPN
     VEALLTPDKD PVLNRNVHQS EAGHQEEGVK KRDPTRVVTF RVPHNAAVQV YDYSQKSARV
     VFGPELVMLE TDEQLTVLSL SGGRPKRPGV IRSLCLLLGP DFFTDVIVIE TADHARLQLQ
     LAYNWHFEVK DRSDPMESAK VFSVLDFVGD ACKAIASRIR GAVASVQFDD FHKNSSRILR
     AAVFGLDPEL RVRERLLFPQ NSLCVTSVDV HSVEPVDQRT RDALQRSVQL AIEITTKSQE
     AAARQEAARL EQEAKGRLER QRILDQAESE RARRELLLLE ADSTAVESRG AARAEAESRA
     EASRIEGEGS VLQAKLKAQA LDIETEAELE RLTKAREREL KYIAEQNRLE VEKTRQLSEL
     ESRRFQEMVQ AIGADTIRAI AESGPELQVK LLQGLGLNST LITDGSTPVN LFSAAKGMLG
     VPAMSMEHRG SE