ID   MVP_ICTPU               Reviewed;         871 AA.
AC   Q9DGM7;
DT   05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   15-AUG-2003, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Major vault protein;
DE            Short=MVP;
DE   Flags: Fragment;
GN   Name=mvp;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Leukocyte;
RA   Rice C.D., Xiang Y.;
RT   "Identification of a major vault protein in channel catfish (Ictalurus
RT   punctatus).";
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for normal vault structure. Vaults are multi-subunit
CC       structures that may act as scaffolds for proteins involved in signal
CC       transduction. Vaults may also play a role in nucleo-cytoplasmic
CC       transport (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The vault ribonucleoprotein particle is a huge (400 A x 670 A)
CC       cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with
CC       each half-vault comprising 39 identical major vault protein (MVP)
CC       chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14764}. Nucleus
CC       {ECO:0000250|UniProtKB:Q14764}.
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DR   EMBL; AF255664; AAG00866.2; -; mRNA.
DR   AlphaFoldDB; Q9DGM7; -.
DR   SMR; Q9DGM7; -.
DR   STRING; 7998.ENSIPUP00000002881; -.
DR   PRIDE; Q9DGM7; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd08825; MVP_shoulder; 1.
DR   Gene3D; 2.30.30.550; -; 4.
DR   Gene3D; 2.30.30.560; -; 2.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR039059; MVP.
DR   InterPro; IPR041139; MVP_rep_dom.
DR   InterPro; IPR043023; MVP_rep_sf.
DR   InterPro; IPR021870; MVP_shoulder.
DR   InterPro; IPR041134; Vault_2.
DR   InterPro; IPR043179; Vault_2_sf.
DR   InterPro; IPR040989; Vault_3.
DR   InterPro; IPR041136; Vault_4.
DR   InterPro; IPR002499; Vault_N.
DR   PANTHER; PTHR14165; PTHR14165; 1.
DR   Pfam; PF11978; MVP_shoulder; 1.
DR   Pfam; PF01505; Vault; 4.
DR   Pfam; PF17794; Vault_2; 2.
DR   Pfam; PF17795; Vault_3; 1.
DR   Pfam; PF17796; Vault_4; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS51224; MVP; 8.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Repeat; Ribonucleoprotein.
FT   CHAIN           1..>871
FT                   /note="Major vault protein"
FT                   /id="PRO_0000158983"
FT   REPEAT          2..69
FT                   /note="MVP 1"
FT   REPEAT          70..124
FT                   /note="MVP 2"
FT   REPEAT          125..177
FT                   /note="MVP 3"
FT   REPEAT          178..230
FT                   /note="MVP 4"
FT   REPEAT          231..285
FT                   /note="MVP 5"
FT   REPEAT          286..336
FT                   /note="MVP 6"
FT   REPEAT          337..407
FT                   /note="MVP 7"
FT   REPEAT          408..482
FT                   /note="MVP 8"
FT   REPEAT          483..545
FT                   /note="MVP 9"
FT   DOMAIN          688..717
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          356..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          684..710
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..370
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        687..710
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         871
SQ   SEQUENCE   871 AA;  97749 MW;  DF109DF903524DD3 CRC64;
     MSKRPAGSHM EHNDLTDASI IRIPPHHYIH VLDQNTNIAR VEVGPLTYIR QDNERVLFSP
     TRMTMVPPRH YCVILNPVAR DDEGHVQFDT AGQAKLRHAD LEIRLTQDPF PLYPGEEIQK
     EVTPLQIVYP DTALRLQALL DFEEESGEKR VAGDEWLFEG PGTYIPRKEV AVLEIIKATV
     IREHQAIRLR ARKEGVDRSG TRRVTGEEWQ VSKVGAYLPG AHEEVIDIVN AFILTDKRAL
     HVRALRPFRD AGGRDRRTGE EWLVTVADRE AHIPSVAEEV VGVVDVTTLN SREYCVILDP
     VGPDGKPQLG QKRVVKGERS FFLRPGEHLE NGIQDVYVLS EEEGLVLRAV EAFNDTEAQE
     EDEEEEEEEE QAKKTSVQRR PGDRWMLRGP IEYVPPVTVE VMLRRQAIPL DENEGIYVRD
     IKTGKVRAVI GHTYMLTHDE ELWEKELPPN VEKLLSTVRD PLADRSEHNQ NAVAEPRDKT
     MVVSYRVPHN AAVQVYDYRE KKARVVFGPD LVMLGPDEQF TVLSLSGEKP KRANVIKAIC
     LLLGPDFCTD IITIETADHA RLQLQLAYNW HFEVKNHSDP AQAAALFSVP DFVGDACKAI
     ASRIRGAVAS VQFDDFHKNS IRIICSAVFG FDEKLAVRSS LRFNQNGLVI SSVDIQSVEP
     VDQRTRDALQ KSVQLAIEIT TNSQEATARH EAERLEQEAR GKLERQKITD QAEAERARKE
     LLELEALSAA VESTGAAKAE AQSRAEAARI QGEAAVQEAK LKVEALRIEA EAEMVRLAKA
     REQELLYKKE LDHLEVEKQQ KLVTIESQRF KQLVEAIGSE TLTAMARAGP ELQVKMLQAL
     GLKSTLITDG SSPINLFTTA NGLLGAMKAP E