ID   MVP_LEIBR               Reviewed;         833 AA.
AC   A4H452;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Major vault protein;
GN   ORFNames=LBRM_05_0060;
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660;
RN   [1] {ECO:0000312|EMBL:CAM36840.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000312|EMBL:CAM36840.1};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- FUNCTION: Required for normal vault structure. Vaults are multi-subunit
CC       structures that may act as scaffolds for proteins involved in signal
CC       transduction. Vaults may also play a role in nucleo-cytoplasmic
CC       transport (By similarity). {ECO:0000250|UniProtKB:Q14764}.
CC   -!- SUBUNIT: The vault ribonucleoprotein particle is a huge (400 A x 670 A)
CC       cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with
CC       each half-vault comprising 39 identical major vault protein (MVP)
CC       chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).
CC       {ECO:0000250|UniProtKB:Q14764}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14764,
CC       ECO:0000255|PROSITE-ProRule:PRU00571}. Nucleus
CC       {ECO:0000250|UniProtKB:Q14764}.
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DR   EMBL; FR798979; CAM36840.1; -; Genomic_DNA.
DR   RefSeq; XP_001561821.1; XM_001561771.1.
DR   AlphaFoldDB; A4H452; -.
DR   SMR; A4H452; -.
DR   STRING; 5660.A4H452; -.
DR   PRIDE; A4H452; -.
DR   GeneID; 5412774; -.
DR   KEGG; lbz:LBRM_05_0060; -.
DR   VEuPathDB; TriTrypDB:LbrM.05.0060; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_050005500; -.
DR   InParanoid; A4H452; -.
DR   OMA; VIRIKRY; -.
DR   Proteomes; UP000007258; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd08825; MVP_shoulder; 1.
DR   Gene3D; 2.30.30.550; -; 4.
DR   Gene3D; 2.30.30.560; -; 2.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR039059; MVP.
DR   InterPro; IPR041139; MVP_rep_dom.
DR   InterPro; IPR043023; MVP_rep_sf.
DR   InterPro; IPR021870; MVP_shoulder.
DR   InterPro; IPR041134; Vault_2.
DR   InterPro; IPR043179; Vault_2_sf.
DR   InterPro; IPR040989; Vault_3.
DR   InterPro; IPR041136; Vault_4.
DR   InterPro; IPR002499; Vault_N.
DR   PANTHER; PTHR14165; PTHR14165; 1.
DR   Pfam; PF11978; MVP_shoulder; 1.
DR   Pfam; PF01505; Vault; 4.
DR   Pfam; PF17794; Vault_2; 1.
DR   Pfam; PF17795; Vault_3; 1.
DR   Pfam; PF17796; Vault_4; 1.
DR   PROSITE; PS51224; MVP; 8.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Ribonucleoprotein.
FT   CHAIN           1..833
FT                   /note="Major vault protein"
FT                   /id="PRO_0000414608"
FT   REPEAT          10..52
FT                   /note="MVP 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          54..115
FT                   /note="MVP 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          119..170
FT                   /note="MVP 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          171..223
FT                   /note="MVP 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          224..278
FT                   /note="MVP 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          280..328
FT                   /note="MVP 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          329..380
FT                   /note="MVP 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          381..433
FT                   /note="MVP 8"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   833 AA;  93280 MW;  E382F37DFF268891 CRC64;
     MTDSVIRIKR YYYIHILDNN TNVTRTISGP VVYTRQEHET CLFDPRPCVS VPPRHYCVVK
     NPCVRNEAGE VVLESSGQVK LRLGDAEIRF EGEPFPLYPG EELDSKEEQS VRKLQVIPPN
     TGLHVRCVRD FKDAERLVVA GTEWMVAGPQ SYIPRVEVAV VEEVKATVIY PNTALLLQAN
     VNFTDRRGVL RVAGEKWLVR TLGAYLPSVE ETVVSLIQGT MLSELKALRL SAVRSFTDVY
     GKARRAGEQW QVTLKDAPVH IVDAYETKVA EVAAVSLNAK EYVIIHHPVD ATGHNRFGET
     LVRRGECTFF LQPEETMPRG VEQVLVVGKE EALLLEAVCE YHDGGGKHQP GSRWMVRGPC
     EYIPANEVKL LEHRRVMALD RNEGIYVMNT TTGEVRAVIG KPYMLDSNEV LWEKHLPLAI
     EELLESPNGS IKTCERNAGF VSRREKYRIV RFNVQHNAAV QIYDYRTKKP RIVLGPSLVM
     LAPHEEFTVL SLSGGTPKVP NSMQSLQLFL GPRFSSDTIV VETSDHARLR LRLSYNWYFD
     IDRANPSQRT FSVPDFIGDC CKTIASRVRG AVAAEDFDSF HRNSAKIIRI AVFGVDEVGE
     AKKNLRFNAN DFVVTNIDVQ SAEPTDEKTR DSLQKSVQLA IEITTKSQEA AARHGNELKN
     QEAKGHLERQ KLIDKIEVEN ARTKWLELQA KSEAVQASGQ SIAEAKARAE ALLIEVQSEM
     QQAEMRAKAY RISAEAELQK LQQRQALELE YTQRQNEIDV AKARAAAEAE AEKVRRMVDA
     IGRDTLVAIA RAGPEAQVKL LGSLGLKGYL ITDGNSPVNL FDAAHGMIGE PKK