ID   MVP_LEIIN               Reviewed;         833 AA.
AC   A4HSC9;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Major vault protein;
GN   ORFNames=LINJ_05_0060;
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671;
RN   [1] {ECO:0000312|EMBL:CAM65315.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000312|EMBL:CAM65315.1};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- FUNCTION: Required for normal vault structure. Vaults are multi-subunit
CC       structures that may act as scaffolds for proteins involved in signal
CC       transduction. Vaults may also play a role in nucleo-cytoplasmic
CC       transport (By similarity). {ECO:0000250|UniProtKB:Q14764}.
CC   -!- SUBUNIT: The vault ribonucleoprotein particle is a huge (400 A x 670 A)
CC       cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with
CC       each half-vault comprising 39 identical major vault protein (MVP)
CC       chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).
CC       {ECO:0000250|UniProtKB:Q14764}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14764,
CC       ECO:0000255|PROSITE-ProRule:PRU00571}. Nucleus
CC       {ECO:0000250|UniProtKB:Q14764}.
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DR   EMBL; FR796437; CAM65315.1; -; Genomic_DNA.
DR   RefSeq; XP_001462970.1; XM_001462933.1.
DR   AlphaFoldDB; A4HSC9; -.
DR   SMR; A4HSC9; -.
DR   STRING; 5671.XP_001462970.1; -.
DR   PRIDE; A4HSC9; -.
DR   GeneID; 5066571; -.
DR   KEGG; lif:LINJ_05_0060; -.
DR   VEuPathDB; TriTrypDB:LINF_050005500; -.
DR   eggNOG; ENOG502QPP0; Eukaryota.
DR   InParanoid; A4HSC9; -.
DR   OMA; VIRIKRY; -.
DR   Proteomes; UP000008153; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd08825; MVP_shoulder; 1.
DR   Gene3D; 2.30.30.550; -; 4.
DR   Gene3D; 2.30.30.560; -; 2.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR039059; MVP.
DR   InterPro; IPR041139; MVP_rep_dom.
DR   InterPro; IPR043023; MVP_rep_sf.
DR   InterPro; IPR021870; MVP_shoulder.
DR   InterPro; IPR041134; Vault_2.
DR   InterPro; IPR043179; Vault_2_sf.
DR   InterPro; IPR040989; Vault_3.
DR   InterPro; IPR041136; Vault_4.
DR   InterPro; IPR002499; Vault_N.
DR   PANTHER; PTHR14165; PTHR14165; 1.
DR   Pfam; PF11978; MVP_shoulder; 1.
DR   Pfam; PF01505; Vault; 4.
DR   Pfam; PF17794; Vault_2; 1.
DR   Pfam; PF17795; Vault_3; 1.
DR   Pfam; PF17796; Vault_4; 1.
DR   PROSITE; PS51224; MVP; 7.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Ribonucleoprotein.
FT   CHAIN           1..833
FT                   /note="Major vault protein"
FT                   /id="PRO_0000414609"
FT   REPEAT          54..118
FT                   /note="MVP 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          119..170
FT                   /note="MVP 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          171..223
FT                   /note="MVP 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          224..278
FT                   /note="MVP 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          280..328
FT                   /note="MVP 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          329..380
FT                   /note="MVP 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          381..433
FT                   /note="MVP 7"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   833 AA;  93170 MW;  82CEF46B990CDEB8 CRC64;
     MTDSVIRIKR YHYIHILDNN TNVTRTISGP VVYTRKEHET CLFDPCPCVS VPPRHYCVVK
     NPCVRGEAGE VVLESSGQVK LRLGDSEIRF EGEPFPLYPG EELDCRDGKG VQKLQLIPPN
     TGLHVRCVRD FKDADRRVGA GTEWMVAGPQ TYIPRVEVVV VEEVKATVIY PNTALLVQAN
     VNFTDRCGVP RVAGEKWLVR ALGAYLKSVE ETVLGLIQGT MLSDLKALRL SAVRSFTDVY
     GKARRAGEQW QVTLKDAPVH IVDAYETKVA DVAAVSLSAK EYVIIHHPVD DTGHNRFGET
     LVRRGECTFF LQPGETMPRG VEQVLVVGKE EALLLEAVCE YRDGGEKRQP GSRWMVHGPL
     EYIPANEVKL LEHRRMMALD KNEGIYIMNT TTGEVRAVIG KPYMLDVNEV LWEKHLPLAV
     EELLESPNGS IQTSERNPGF VSHREKYRIV RFNVQHNAAV QIYDYRKKQP RIVLGPNLVM
     LAPHEEFTVL SLSGGTPKVP NSLQSLQLFL GPRFSSDTIV VETSDHARLR LRLSYNWYFD
     IDRANPSRRT FSVPDFIGDC CKTIASRVRG AVAAEDFDSF HRNSAKIIRT AVFGVDEAGE
     TKKNLRFTAN DFVVTNIDVQ SSEPTDEKTR DSLQKSVQLA IEITTKSQEA AARHGNELKD
     QEAKGQLERQ KLLDKIEVEN ARTKWLELQA KSEAVQASGQ SVAEAKARAE ALFIEVRSEM
     QQAEMRAKAY RISAEAELQK LQQRQALELE YTQRQNEIDV SKARAAAEAE AEKVKRMVDC
     IGRDTLVAIA RAGPETQVKL LSSLGLKGYL ITDGNSPVNL FGTAQGMIGE PKK