MVP_LEIMA
ID MVP_LEIMA Reviewed; 833 AA.
AC Q4QJJ7;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Major vault protein;
GN ORFNames=LMJF_05_0060;
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664;
RN [1] {ECO:0000312|EMBL:CAJ01922.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000312|EMBL:CAJ01922.1};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B.G., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
CC -!- FUNCTION: Required for normal vault structure. Vaults are multi-subunit
CC structures that may act as scaffolds for proteins involved in signal
CC transduction. Vaults may also play a role in nucleo-cytoplasmic
CC transport (By similarity). {ECO:0000250|UniProtKB:Q14764}.
CC -!- SUBUNIT: The vault ribonucleoprotein particle is a huge (400 A x 670 A)
CC cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with
CC each half-vault comprising 39 identical major vault protein (MVP)
CC chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).
CC {ECO:0000250|UniProtKB:Q14764}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14764,
CC ECO:0000255|PROSITE-ProRule:PRU00571}. Nucleus
CC {ECO:0000250|UniProtKB:Q14764}.
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DR EMBL; FR796401; CAJ01922.1; -; Genomic_DNA.
DR RefSeq; XP_001687482.1; XM_001687430.1.
DR AlphaFoldDB; Q4QJJ7; -.
DR SMR; Q4QJJ7; -.
DR STRING; 5664.LmjF.05.0060; -.
DR EnsemblProtists; CAJ01922; CAJ01922; LMJF_05_0060.
DR GeneID; 5648865; -.
DR KEGG; lma:LMJF_05_0060; -.
DR VEuPathDB; TriTrypDB:LmjF.05.0060; -.
DR VEuPathDB; TriTrypDB:LMJLV39_050005500; -.
DR VEuPathDB; TriTrypDB:LMJSD75_050005500; -.
DR eggNOG; ENOG502QPP0; Eukaryota.
DR HOGENOM; CLU_016171_0_0_1; -.
DR InParanoid; Q4QJJ7; -.
DR OMA; VIRIKRY; -.
DR Proteomes; UP000000542; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR CDD; cd08825; MVP_shoulder; 1.
DR Gene3D; 2.30.30.550; -; 4.
DR Gene3D; 2.30.30.560; -; 2.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR039059; MVP.
DR InterPro; IPR041139; MVP_rep_dom.
DR InterPro; IPR043023; MVP_rep_sf.
DR InterPro; IPR021870; MVP_shoulder.
DR InterPro; IPR041134; Vault_2.
DR InterPro; IPR043179; Vault_2_sf.
DR InterPro; IPR040989; Vault_3.
DR InterPro; IPR041136; Vault_4.
DR InterPro; IPR002499; Vault_N.
DR PANTHER; PTHR14165; PTHR14165; 1.
DR Pfam; PF11978; MVP_shoulder; 1.
DR Pfam; PF01505; Vault; 4.
DR Pfam; PF17794; Vault_2; 1.
DR Pfam; PF17795; Vault_3; 1.
DR Pfam; PF17796; Vault_4; 1.
DR PROSITE; PS51224; MVP; 7.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Ribonucleoprotein.
FT CHAIN 1..833
FT /note="Major vault protein"
FT /id="PRO_0000414610"
FT REPEAT 54..118
FT /note="MVP 1"
FT /evidence="ECO:0000255"
FT REPEAT 119..170
FT /note="MVP 2"
FT /evidence="ECO:0000255"
FT REPEAT 171..223
FT /note="MVP 3"
FT /evidence="ECO:0000255"
FT REPEAT 224..278
FT /note="MVP 4"
FT /evidence="ECO:0000255"
FT REPEAT 280..328
FT /note="MVP 5"
FT /evidence="ECO:0000255"
FT REPEAT 329..380
FT /note="MVP 6"
FT /evidence="ECO:0000255"
FT REPEAT 381..433
FT /note="MVP 7"
FT /evidence="ECO:0000255"
SQ SEQUENCE 833 AA; 93301 MW; 05EC673FEB919D39 CRC64;
MSDSVIRIKR YHYIHILDNN TNVTRTISGP VVYTRKEHET CLFDPCPCVS VPPRHYCVVK
NPCVRDEAGE VVLESSGQVK LRLGDAEIRF EGEPFPLYPG EELDCRDGKG VQKLQLIPPN
TGLHVRCVRD FKDADRLVGA GTEWMVAGPQ TYIPRVEVVV VEEVKATVIY PNTALMVQAN
VNFTDRGGVP RVAGEKWLVR ALGAYLQSVE ETVLGLIQGT MLSDLKALRL SAVRSFTDVY
GKGRRAGEQW QVTLKDAPVH IIDAYEMKVA DVAAVSLSAK EYVIIHHPVD DTGHNRFGET
LVRRGECTFF LQPGETMPRG VEQVLVVGKE EALLLEAVCE YRDRGEKRQP GSRWMVRGPL
EYIPANEVKL LEHRRMMALD KNEGIYVMNT TTGEVRAVIG KPYMLDVNEV LWEKHLPLAV
EELLESPNGS IQTSERNPGF VSHREKYRIV RFNVQHNAAV QIYDYRKKQP RIVLGPNLVM
LAPHEEFTVL SLSGGTPKVP NSLQSLQLFL GPRFSSDTIV VETSDHARLR LRLSYNWYFD
IDRVNPSQRT FSVPDFIGDC CKTIASRVRG AVASEDFDSF HRNSAKIIRT AVFGVDETGE
TKKNLRFTAN DFVVTNIDVQ SSEPTDEKTR DSLQKSVQLA IEITTKSQEA AARHGNELKD
QEAKGQLERQ KLLDKIEVEN ARTKWLELQA KSEAVQASGQ SVAEAKARAE ALLIEVRSEM
QQAEMRARAY RISAEAELQK LQQRQALELE YTQRQNEIDV SKARAAAEAE AEKVKRMVDC
IGRDTLVAIA RAGPETQVKL LSSLGLKGYL ITDGNSPVNL FGTAQGMIGE PKK
