ID   A14_FOWPN               Reviewed;          91 AA.
AC   Q9J554;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   23-FEB-2022, entry version 57.
DE   RecName: Full=Virion membrane protein A14 homolog;
GN   OrderedLocusNames=FPV179;
OS   Fowlpox virus (strain NVSL) (FPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Avipoxvirus.
OX   NCBI_TaxID=928301;
OH   NCBI_TaxID=7742; Vertebrata.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10729156; DOI=10.1128/jvi.74.8.3815-3831.2000;
RA   Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT   "The genome of fowlpox virus.";
RL   J. Virol. 74:3815-3831(2000).
CC   -!- FUNCTION: Envelope protein which is a major component of the mature
CC       virion (MV) membrane. Essential for membrane biogenesis. Is required,
CC       together with A17, to form bona fide crescents, which can progress to
CC       form the immature virion (IV) membrane. A14 and A17 form a lattice that
CC       is stabilized by disulfide bonds and serves as an anchor within the
CC       viral membrane to which several other proteins important in virion
CC       structure and morphogenesis attach (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with A17.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}. Note=Component of the mature virion
CC       (MV) membrane. {ECO:0000250}.
CC   -!- PTM: Phosphorylated by viral F10 kinase, phosphorylation state is
CC       regulated by H1 phosphatase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A14 family. {ECO:0000305}.
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DR   EMBL; AF198100; AAF44523.1; -; Genomic_DNA.
DR   RefSeq; NP_039142.1; NC_002188.1.
DR   SMR; Q9J554; -.
DR   GeneID; 1486727; -.
DR   KEGG; vg:1486727; -.
DR   Proteomes; UP000008597; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008785; Poxvirus_A14.
DR   Pfam; PF05767; Pox_A14; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix; Viral envelope protein; Virion.
FT   CHAIN           1..91
FT                   /note="Virion membrane protein A14 homolog"
FT                   /id="PRO_0000099244"
FT   TOPO_DOM        1..12
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..46
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..91
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   DISULFID        72
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   91 AA;  9950 MW;  64FE7AEECFD3849D CRC64;
     MDPLGFFRNR PSYVVVFGII LLIVACICAY IELSKSGKPA DSALRSISII SFILAILLLL
     GIILFSGYNR YCTGNVVDES RYATSPGTEI Q