ID   MVP_RRSVT               Reviewed;         592 AA.
AC   O56045;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   23-FEB-2022, entry version 43.
DE   RecName: Full=Movement and RNA silencing protein VP6;
OS   Rice ragged stunt virus (isolate Thailand) (RRSV).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Oryzavirus.
OX   NCBI_TaxID=649603;
OH   NCBI_TaxID=4534; Oryza latifolia.
OH   NCBI_TaxID=4536; Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea).
OH   NCBI_TaxID=4529; Oryza rufipogon (Brownbeard rice) (Asian wild rice).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Upadhyaya N.M., Li Z., Ramm K., Yang M., Gellatly J.A., Kositratana W.,
RA   Gerlach W.L., Waterhouse P.M.;
RT   "Rice ragged stunt oryzavirus:complete sequence and genome organization.";
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=15248020; DOI=10.1093/abbs/36.7.457;
RA   Shao C.G., Lu H.J., Wu J.H., Gong Z.X.;
RT   "Nucleic acid binding activity of pns6 encoded by genome segment 6 of rice
RT   ragged stunt oryzavirus.";
RL   Acta Biochim. Biophys. Sin. 36:457-466(2004).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=20541571; DOI=10.1016/j.virusres.2010.06.003;
RA   Wu Z., Wu J., Adkins S., Xie L., Li W.;
RT   "Rice ragged stunt virus segment S6-encoded nonstructural protein Pns6
RT   complements cell-to-cell movement of Tobacco mosaic virus-based chimeric
RT   virus.";
RL   Virus Res. 152:176-179(2010).
RN   [4]
RP   FUNCTION.
RX   PubMed=21092155; DOI=10.1186/1743-422x-7-335;
RA   Wu J., Du Z., Wang C., Cai L., Hu M., Lin Q., Wu Z., Li Y., Xie L.;
RT   "Identification of Pns6, a putative movement protein of RRSV, as a
RT   silencing suppressor.";
RL   Virol. J. 7:335-335(2010).
CC   -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC       through plasmosdesmata, without any budding. The movement protein
CC       allows efficient cell to cell propagation, by bypassing the host cell
CC       wall barrier. Displays sequence non-specific nucleic acid binding
CC       activity. Acts as a suppressor of RNA-mediated gene silencing, also
CC       known as post-transcriptional gene silencing (PTGS), a mechanism of
CC       plant viral defense that limits the accumulation of viral RNAs.
CC       {ECO:0000269|PubMed:15248020, ECO:0000269|PubMed:20541571,
CC       ECO:0000269|PubMed:21092155}.
CC   -!- SUBCELLULAR LOCATION: Host cell junction, host plasmodesma
CC       {ECO:0000269|PubMed:20541571}.
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DR   EMBL; AF020337; AAC04675.1; -; Genomic_RNA.
DR   RefSeq; NP_620517.1; NC_003752.1.
DR   GeneID; 991198; -.
DR   KEGG; vg:991198; -.
DR   Proteomes; UP000000348; Genome.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Host cell junction; Nucleotide-binding; Reference proteome; RNA-binding;
KW   Suppressor of RNA silencing; Transport; Viral movement protein.
FT   CHAIN           1..592
FT                   /note="Movement and RNA silencing protein VP6"
FT                   /id="PRO_0000403632"
FT   REGION          450..469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   592 AA;  65767 MW;  D491BCC38272049F CRC64;
     MQLFIVKLDS RSSASNEILV LDINELRKYV SKHQLSFRGA QVHETNSEHS VRNWEDDNIT
     MFFHTSNVFP SEKSVRHALF SRNSVHVCGP LNIGAFRDSL RVLQSPQFPI HTYGDDITVF
     DKLREFVVVP NSLAVVDMDT SAWERYTYSL FTDEPGTITL ADETPPTISP TGRDSVSPVA
     RFSPSISISS IAIGEVGSAS KRRQRLVKQA KSSDKTPIPE IRLNKKDTVF AETGTEQASP
     KTEIVAATVH KIPVNHAEAD KRVVVLKGRT KDKAQEVREV TSLARDTTGV EHELMQSVGD
     DSVQVSGELS GFGDESFEVS KTDVVGVENK QLALDRVPAL EPCGEVSEDE ELVSEGMYAV
     PLDLDIYAEK CPSPTPPNSP KKREKADHEP IDISSAMMKL RLIAAAFQKE MMAYDKIDCL
     SSDDPAYLLA QFCLRNLNGV FVPEYVEEHS SDEENADDPN QGWNGTPVHG SREIFEKLSE
     SRLASMEMIS NVKPIRWNSK KTTYAVTIER GNPNLIVTQS LTRGQSSQFR KVIRAFGCST
     DYCLERLASR DYDAILMLMS SLSGACHATK SYCYLQIVAY GSFAAPECKE LD