ID   MVP_TBRFV               Reviewed;         266 AA.
AC   A0A0S2SZW1;
DT   11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT   17-FEB-2016, sequence version 1.
DT   02-JUN-2021, entry version 23.
DE   RecName: Full=Movement protein;
DE   AltName: Full=30 kDa protein;
DE   AltName: Full=Cell-to-cell transport protein;
GN   Name=MP; Synonyms=MP30;
OS   Tomato brown rugose fruit virus (isolate TOBRFV/Tomato/Jordan/Tom1-Jo/2015)
OS   (ToBRFV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Martellivirales; Virgaviridae; Tobamovirus.
OX   NCBI_TaxID=2654645;
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=26586328; DOI=10.1007/s00705-015-2677-7;
RA   Salem N., Mansour A., Ciuffo M., Falk B.W., Turina M.;
RT   "A new tobamovirus infecting tomato crops in Jordan.";
RL   Arch. Virol. 161:503-506(2016).
RN   [2]
RP   FUNCTION.
RX   PubMed=28107419; DOI=10.1371/journal.pone.0170429;
RA   Luria N., Smith E., Reingold V., Bekelman I., Lapidot M., Levin I.,
RA   Elad N., Tam Y., Sela N., Abu-Ras A., Ezra N., Haberman A., Yitzhak L.,
RA   Lachman O., Dombrovsky A.;
RT   "A new Israeli tobamovirus isolate infects tomato plants harboring Tm-2(2)
RT   resistance genes.";
RL   PLoS ONE 12:E0170429-E0170429(2017).
RN   [3]
RP   REVIEW.
RX   DOI=10.1111/ppa.13096;
RA   Oladokun J.O., Halabi M.H., Barua P., Nath P.D.;
RT   "Tomato brown rugose fruit disease: current distribution, knowledge and
RT   future prospects.";
RL   (er) Plant pathology:1-8 (2019).
CC   -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC       through plasmosdesmata, without any budding. The movement protein
CC       allows efficient cell to cell propagation, by bypassing the host cell
CC       wall barrier. Forms a ribonucleoprotein complex with viral RNA. Binds
CC       microtubules and modulates microtubule stability. Can bind double-
CC       stranded DNA. Evades host resistance (R) protein (e.g. tomato ToMV
CC       resistance protein TM-2(2), AC Q71BG9) in ToMV/TMV resistant plants
CC       (PubMed:28107419). {ECO:0000250|UniProtKB:P03583,
CC       ECO:0000269|PubMed:28107419}.
CC   -!- SUBUNIT: Binds to host RBCS at the plasmodesmata; this interaction
CC       seems required for viral systemic movement.
CC       {ECO:0000250|UniProtKB:P69513}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytoskeleton
CC       {ECO:0000250|UniProtKB:P69513}. Host cell junction, host plasmodesma
CC       {ECO:0000250|UniProtKB:P69513}. Note=Binds to the host cytoskeleton
CC       before being transported to the host plasmodesmata.
CC       {ECO:0000250|UniProtKB:P69513}.
CC   -!- MISCELLANEOUS: The ToBRFV MVP has gained resistance to antiviral Tm-
CC       2(2) defense, thereby allowing it to spread from Jordan to most of the
CC       world tomato's cultures and pose a major threat to agriculture.
CC       {ECO:0000305|Ref.3}.
CC   -!- SIMILARITY: Belongs to the tobamovirus movement protein family.
CC       {ECO:0000305}.
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DR   EMBL; KT383474; ALP48478.1; -; Genomic_RNA.
DR   EMBL; MK133093; AZQ25013.1; -; Genomic_RNA.
DR   RefSeq; YP_009182170.1; NC_028478.1.
DR   GeneID; 26373866; -.
DR   KEGG; vg:26373866; -.
DR   Proteomes; UP000203541; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001022; TMV_movement.
DR   InterPro; IPR028919; Viral_movement.
DR   Pfam; PF01107; MP; 1.
DR   PRINTS; PR00964; MOVEMENT.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; DNA-binding; Host cell junction;
KW   Host cytoplasm; Host cytoskeleton; Host-virus interaction; RNA-binding;
KW   Transport; Viral movement protein.
FT   CHAIN           1..266
FT                   /note="Movement protein"
FT                   /id="PRO_0000448840"
FT   REGION          211..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   266 AA;  29791 MW;  892DE08D1F9DA09A CRC64;
     MALVKGKVNI NEFIDLSKSE KFLPSMFTPV KSVMISKVDK ILVHEDESLS EVNLLKGVKL
     IDGGYVHLAG LVVTGEWNLP DNCRGGVSVC LVDKRMERAD EATLASYYTA AAKKRFQFKV
     VPNYNITTKD AEKAVWQVLV NIRNVKIAAG YCPLSLEFVS VCIVYKNIIK LGLREKITSV
     TDGGPMELSE EVVDEFMEEV PMSVRLAKFR SKTGKKFSSK SENNSGNNRP KPDKNQRKEK
     GLKVRVEKDN LIDNELETYV ADSDSY