MVP_TMV
ID MVP_TMV Reviewed; 268 AA.
AC P03583;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 02-JUN-2021, entry version 78.
DE RecName: Full=Movement protein;
DE AltName: Full=30 kDa protein;
DE AltName: Full=Cell-to-cell transport protein;
DE Contains:
DE RecName: Full=27.9 kDa protein;
DE Contains:
DE RecName: Full=25.3 kDa protein;
DE Contains:
DE RecName: Full=19.5 kDa protein;
GN Name=MP; Synonyms=MP30 {ECO:0000303|PubMed:12913144};
OS Tobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain
OS U1)).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Martellivirales; Virgaviridae; Tobamovirus.
OX NCBI_TaxID=12243;
OH NCBI_TaxID=4097; Nicotiana tabacum (Common tobacco).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=6964389; DOI=10.1073/pnas.79.19.5818;
RA Goelet P., Lomonossoff G.P., Butler P.J.G., Akam M.E., Gait M.J., Karn J.;
RT "Nucleotide sequence of tobacco mosaic virus RNA.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:5818-5822(1982).
RN [2]
RP INTERACTION WITH HOST MBP2C.
RC STRAIN=cv. Samsun NN, and cv. Turkish;
RX PubMed=12913144; DOI=10.1104/pp.103.022269;
RA Kragler F., Curin M., Trutnyeva K., Gansch A., Waigmann E.;
RT "MPB2C, a microtubule-associated plant protein binds to and interferes with
RT cell-to-cell transport of tobacco mosaic virus movement protein.";
RL Plant Physiol. 132:1870-1883(2003).
RN [3]
RP FUNCTION.
RX PubMed=16912284; DOI=10.1128/jvi.00540-06;
RA Ashby J., Boutant E., Seemanpillai M., Groner A., Sambade A.,
RA Ritzenthaler C., Heinlein M.;
RT "Tobacco mosaic virus movement protein functions as a structural
RT microtubule-associated protein.";
RL J. Virol. 80:8329-8344(2006).
RN [4]
RP FUNCTION, AND INTERACTION WITH HOST MBP2C.
RX PubMed=17965274; DOI=10.1105/tpc.107.044354;
RA Winter N., Kollwig G., Zhang S., Kragler F.;
RT "MPB2C, a microtubule-associated protein, regulates non-cell-autonomy of
RT the homeodomain protein KNOTTED1.";
RL Plant Cell 19:3001-3018(2007).
RN [5]
RP INTERACTION WITH HOST TOMATO TOMV RESISTANCE PROTEIN TM-2(2), AND
RP SUBCELLULAR LOCATION.
RX PubMed=28258211; DOI=10.1104/pp.16.01512;
RA Chen T., Liu D., Niu X., Wang J., Qian L., Han L., Liu N., Zhao J.,
RA Hong Y., Liu Y.;
RT "Antiviral resistance protein Tm-2(2) functions on the plasma membrane.";
RL Plant Physiol. 173:2399-2410(2017).
CC -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC through plasmosdesmata, without any budding. The movement protein
CC allows efficient cell to cell propagation, by bypassing the host cell
CC wall barrier. Forms a ribonucleoprotein complex with viral RNA. Binds
CC microtubules and modulates microtubule stability. Can bind double-
CC stranded DNA (PubMed:17965274). Triggers host hypersensitive defense
CC reaction in incompatible plants harboring resistance (R) proteins.
CC {ECO:0000250|UniProtKB:P69513, ECO:0000269|PubMed:16912284,
CC ECO:0000269|PubMed:17965274}.
CC -!- SUBUNIT: Binds to host RBCS at the plasmodesmata; this interaction
CC seems required for viral systemic movement (By similarity). In
CC resistant plants, interacts with host MBP2C at host microtubules; this
CC interaction prevents virus cell to cell movement (PubMed:12913144,
CC PubMed:17965274). In resistant plants, interacts with host resistance
CC (R) protein (e.g. tomato ToMV resistance protein TM-2(2), AC Q71BG9) at
CC the host plasma membrane; this interaction triggers host defense
CC responses leading to programmed cell death (PubMed:28258211).
CC {ECO:0000250|UniProtKB:A0A0S4IJL0, ECO:0000250|UniProtKB:P69513,
CC ECO:0000269|PubMed:12913144, ECO:0000269|PubMed:17965274,
CC ECO:0000269|PubMed:28258211}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytoskeleton
CC {ECO:0000250|UniProtKB:P69513}. Host cell junction, host plasmodesma
CC {ECO:0000250|UniProtKB:P69513}. Note=Binds to the host cytoskeleton
CC before being transported to the host plasmodesmata. Observed in virus
CC replication complexes (VRCs) of tobamovirus infected host cells (By
CC similarity). In resistant plants, targeted to the host plasma membrane
CC via the interaction with host resistance (R) protein TM-2 (e.g. tomato
CC ToMV resistance protein TM-2(2), AC Q71BG9) (PubMed:28258211).
CC {ECO:0000250|UniProtKB:P69513, ECO:0000269|PubMed:28258211}.
CC -!- SIMILARITY: Belongs to the tobamovirus movement protein family.
CC {ECO:0000305}.
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DR EMBL; V01408; -; NOT_ANNOTATED_CDS; Unassigned_RNA.
DR EMBL; V01409; CAA24689.1; -; Genomic_RNA.
DR RefSeq; NP_597748.1; NC_001367.1.
DR PRIDE; P03583; -.
DR GeneID; 1494078; -.
DR KEGG; vg:1494078; -.
DR Proteomes; UP000000522; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0020002; C:host cell plasma membrane; IDA:UniProtKB.
DR GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR GO; GO:0044163; C:host cytoskeleton; IDA:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR InterPro; IPR001022; TMV_movement.
DR InterPro; IPR028919; Viral_movement.
DR Pfam; PF01107; MP; 1.
DR PRINTS; PR00964; MOVEMENT.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; DNA-binding; Host cell junction;
KW Host cytoplasm; Host cytoskeleton; Host-virus interaction;
KW Reference proteome; RNA-binding; Transport; Viral movement protein.
FT CHAIN 1..268
FT /note="Movement protein"
FT /id="PRO_0000041154"
FT CHAIN 20..268
FT /note="27.9 kDa protein"
FT /id="PRO_0000041155"
FT CHAIN 43..268
FT /note="25.3 kDa protein"
FT /id="PRO_0000041156"
FT CHAIN 97..268
FT /note="19.5 kDa protein"
FT /id="PRO_0000041157"
FT REGION 212..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 268 AA; 30004 MW; BE8719A54854FE59 CRC64;
MALVVKGKVN INEFIDLTKM EKILPSMFTP VKSVMCSKVD KIMVHENESL SEVNLLKGVK
LIDSGYVCLA GLVVTGEWNL PDNCRGGVSV CLVDKRMERA DEATLGSYYT AAAKKRFQFK
VVPNYAITTQ DAMKNVWQVL VNIRNVKMSA GFCPLSLEFV SVCIVYRNNI KLGLREKITN
VRDGGPMELT EEVVDEFMED VPMSIRLAKF RSRTGKKSDV RKGKNSSNDR SVPNKNYRNV
KDFGGMSFKK NNLIDDDSEA TVAESDSF
