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MVP_TMVRA
ID   MVP_TMVRA               Reviewed;         268 AA.
AC   Q98746;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Movement protein;
DE   AltName: Full=30 kDa protein;
DE   AltName: Full=Cell-to-cell transport protein;
GN   Name=MP; Synonyms=MP30;
OS   Tobacco mosaic virus (strain Rakkyo) (TMV-R).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Martellivirales; Virgaviridae; Tobamovirus.
OX   NCBI_TaxID=138310;
OH   NCBI_TaxID=130426; Allium chinense.
OH   NCBI_TaxID=4097; Nicotiana tabacum (Common tobacco).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8678834; DOI=10.1007/bf01718163;
RA   Chen J., Watanabe Y., Sako N., Ohsima K., Okada Y.;
RT   "Complete nucleotide sequence and synthesis of infectious in vitro
RT   transcripts from a full-length cDNA clone of a rakkyo strain of tobacco
RT   mosaic virus.";
RL   Arch. Virol. 141:885-900(1996).
CC   -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC       through plasmosdesmata, without any budding. The movement protein
CC       allows efficient cell to cell propagation, by bypassing the host cell
CC       wall barrier. Forms a ribonucleoprotein complex with viral RNA. Binds
CC       microtubules and modulates microtubule stability. Can bind double-
CC       stranded DNA. Triggers host hypersensitive defense reaction in
CC       incompatible plants harboring resistance (R) proteins.
CC       {ECO:0000250|UniProtKB:P03583, ECO:0000250|UniProtKB:P69513}.
CC   -!- SUBUNIT: Binds to host RBCS at the plasmodesmata; this interaction
CC       seems required for viral systemic movement (By similarity). In
CC       resistant plants, interacts with host MBP2C at host microtubules; this
CC       interaction prevents virus cell to cell movement. In resistant plants,
CC       interacts with host resistance (R) protein (e.g. tomato ToMV resistance
CC       protein TM-2(2), AC Q71BG9) at the host plasma membrane; this
CC       interaction triggers host defense responses leading to programmed cell
CC       death (By similarity). {ECO:0000250|UniProtKB:A0A0S4IJL0,
CC       ECO:0000250|UniProtKB:P03583, ECO:0000250|UniProtKB:P69513}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytoskeleton
CC       {ECO:0000250|UniProtKB:P69513}. Host cell junction, host plasmodesma
CC       {ECO:0000250|UniProtKB:P69513}. Note=Binds to the host cytoskeleton
CC       before being transported to the host plasmodesmata. Observed in virus
CC       replication complexes (VRCs) of tobamovirus infected host cells (By
CC       similarity). In resistant plants, targeted to the host plasma membrane
CC       via the interaction with host resistance (R) protein TM-2 (e.g. tomato
CC       ToMV resistance protein TM-2(2), AC Q71BG9) (By similarity).
CC       {ECO:0000250|UniProtKB:P03583, ECO:0000250|UniProtKB:P69513}.
CC   -!- SIMILARITY: Belongs to the tobamovirus movement protein family.
CC       {ECO:0000305}.
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DR   EMBL; D63809; BAA09878.1; -; Genomic_RNA.
DR   Proteomes; UP000008251; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0044163; C:host cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001022; TMV_movement.
DR   InterPro; IPR028919; Viral_movement.
DR   Pfam; PF01107; MP; 1.
DR   PRINTS; PR00964; MOVEMENT.
PE   3: Inferred from homology;
KW   Host cell junction; Host cytoplasm; Host cytoskeleton;
KW   Host-virus interaction; Reference proteome; RNA-binding; Transport;
KW   Viral movement protein.
FT   CHAIN           1..268
FT                   /note="Movement protein"
FT                   /id="PRO_0000144955"
FT   REGION          217..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   268 AA;  29850 MW;  2E843BE774DF312F CRC64;
     MALVVKGKVN INEFIDLTKM EKILPSMFTP VKSVMCSKVD KIMVHENESL SEVNLLKGVK
     LIDSGYVCLA GLVVTGEWNL PDNCRGGVSV CLVDKRMERA DEATLGSYYT AAAKKRFQFK
     VVPNYAITTQ DAMKNVWQVL VNIRNVKMSA GFCPLSLEFV SVCIVYRNNI KIGLREKITN
     VRDGGPMELT EEVVDEFMED VPMSIRLAKF RSRTGKKSVV PKGNFSSRDR SQPNKNYGNA
     KDFGGMSFKK NNLIDDGSET SVAESDSF
 
 
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