ID   MVP_TOMK2               Reviewed;         264 AA.
AC   P69512; P03584;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   02-JUN-2021, entry version 35.
DE   RecName: Full=Movement protein;
DE   AltName: Full=30 kDa protein;
DE   AltName: Full=Cell-to-cell transport protein;
GN   Name=MP;
OS   Tomato mosaic virus (strain Kazakh K2) (ToMV) (TMV strain K2).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Martellivirales; Virgaviridae; Tobamovirus.
OX   NCBI_TaxID=138312;
OH   NCBI_TaxID=4151; Antirrhinum majus (Garden snapdragon).
OH   NCBI_TaxID=4071; Capsicum (peppers).
OH   NCBI_TaxID=46246; Delphinium.
OH   NCBI_TaxID=4101; Petunia.
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=13707; Tagetes (marigolds).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9454068;
RA   Belenovich E.V., Generozov E.V., Novikov V.K., Zavriev S.K.;
RT   "Properties and structure of the tobacco mosaic virus strain K2 genome.";
RL   Mol. Biol. (Mosk.) 31:826-830(1997).
CC   -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC       through plasmosdesmata, without any budding. The movement protein
CC       allows efficient cell to cell propagation, by bypassing the host cell
CC       wall barrier. Forms a ribonucleoprotein complex with viral RNA. Binds
CC       microtubules and modulates microtubule stability. Can bind double-
CC       stranded DNA. Triggers host hypersensitive defense reaction in
CC       incompatible plants harboring resistance (R) proteins.
CC       {ECO:0000250|UniProtKB:P03583, ECO:0000250|UniProtKB:P69513}.
CC   -!- SUBUNIT: Binds to host RBCS at the plasmodesmata; this interaction
CC       seems required for viral systemic movement (By similarity). In
CC       resistant plants, interacts with host MBP2C at host microtubules; this
CC       interaction prevents virus cell to cell movement. In resistant plants,
CC       interacts with host resistance (R) protein (e.g. tomato ToMV resistance
CC       protein TM-2(2), AC Q71BG9) at the host plasma membrane; this
CC       interaction triggers host defense responses leading to programmed cell
CC       death (By similarity). {ECO:0000250|UniProtKB:A0A0S4IJL0,
CC       ECO:0000250|UniProtKB:P03583, ECO:0000250|UniProtKB:P69513}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytoskeleton
CC       {ECO:0000250|UniProtKB:P69513}. Host cell junction, host plasmodesma
CC       {ECO:0000250|UniProtKB:P69513}. Note=Binds to the host cytoskeleton
CC       before being transported to the host plasmodesmata. Observed in virus
CC       replication complexes (VRCs) of tobamovirus infected host cells (By
CC       similarity). In resistant plants, targeted to the host plasma membrane
CC       via the interaction with host resistance (R) protein TM-2 (e.g. tomato
CC       ToMV resistance protein TM-2(2), AC Q71BG9) (By similarity).
CC       {ECO:0000250|UniProtKB:P03583, ECO:0000250|UniProtKB:P69513}.
CC   -!- SIMILARITY: Belongs to the tobamovirus movement protein family.
CC       {ECO:0000305}.
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DR   EMBL; Z92909; CAB07440.1; -; Genomic_RNA.
DR   Proteomes; UP000008253; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001022; TMV_movement.
DR   InterPro; IPR028919; Viral_movement.
DR   Pfam; PF01107; MP; 1.
DR   PRINTS; PR00964; MOVEMENT.
PE   3: Inferred from homology;
KW   Host cell junction; Host cytoplasm; Host cytoskeleton; RNA-binding;
KW   Transport; Viral movement protein.
FT   CHAIN           1..264
FT                   /note="Movement protein"
FT                   /id="PRO_0000144969"
FT   REGION          211..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..264
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   264 AA;  29291 MW;  3B01EB2359AF9C4E CRC64;
     MALVVKGKVN INEFIDLSKS EKLLPSMFTP VKSVMVSKVD KIMVHENESL SEVNLLKGVK
     LIEGGYVCLV GLVVSGEWNL PDNCRGGVSV CMVDKRMERA DEATLGSYYT AAAKKRFQFK
     VVPNYGITTK DAEKNIWQVL VNIKNVKMSA GYCPLSLEFV SVCIVYKNNI KLGLREKVTS
     VNDGGPMELS EEVVDEFMEN VPMSVRLAKF RTKSSKRGPK NNNNLGKGRS GGRPKPKSFD
     EVEKEFDNLI EDEAETSVAD SDSY