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MVP_TOMS1
ID   MVP_TOMS1               Reviewed;         264 AA.
AC   Q9YJQ9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Movement protein;
DE   AltName: Full=30 kDa protein;
DE   AltName: Full=Cell-to-cell transport protein;
GN   Name=MP;
OS   Tomato mosaic virus (strain S-1) (ToMV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Martellivirales; Virgaviridae; Tobamovirus.
OX   NCBI_TaxID=138314;
OH   NCBI_TaxID=4151; Antirrhinum majus (Garden snapdragon).
OH   NCBI_TaxID=4071; Capsicum (peppers).
OH   NCBI_TaxID=46246; Delphinium.
OH   NCBI_TaxID=4101; Petunia.
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=13707; Tagetes (marigolds).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Zhou X., Xue C., Chen Q., Qi Y., Li D.;
RT   "Complete nucleotide sequence of a Chinese isolate of tomato mosaic
RT   virus.";
RL   Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-200.
RA   Zhou X., Xue C., Qi Y., Li D.;
RT   "Isolation and nucleotide sequence of the 30k and the coat protein cistron
RT   of a Chinese isolate of tomato mosaic virus.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC       through plasmosdesmata, without any budding. The movement protein
CC       allows efficient cell to cell propagation, by bypassing the host cell
CC       wall barrier. Forms a ribonucleoprotein complex with viral RNA. Binds
CC       microtubules and modulates microtubule stability. Can bind double-
CC       stranded DNA. Triggers host hypersensitive defense reaction in
CC       incompatible plants harboring resistance (R) proteins.
CC       {ECO:0000250|UniProtKB:P03583, ECO:0000250|UniProtKB:P69513}.
CC   -!- SUBUNIT: Binds to host RBCS at the plasmodesmata; this interaction
CC       seems required for viral systemic movement (By similarity). In
CC       resistant plants, interacts with host MBP2C at host microtubules; this
CC       interaction prevents virus cell to cell movement. In resistant plants,
CC       interacts with host resistance (R) protein (e.g. tomato ToMV resistance
CC       protein TM-2(2), AC Q71BG9) at the host plasma membrane; this
CC       interaction triggers host defense responses leading to programmed cell
CC       death (By similarity). {ECO:0000250|UniProtKB:A0A0S4IJL0,
CC       ECO:0000250|UniProtKB:P03583, ECO:0000250|UniProtKB:P69513}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytoskeleton
CC       {ECO:0000250|UniProtKB:P69513}. Host cell junction, host plasmodesma
CC       {ECO:0000250|UniProtKB:P69513}. Note=Binds to the host cytoskeleton
CC       before being transported to the host plasmodesmata. Observed in virus
CC       replication complexes (VRCs) of tobamovirus infected host cells (By
CC       similarity). In resistant plants, targeted to the host plasma membrane
CC       via the interaction with host resistance (R) protein TM-2 (e.g. tomato
CC       ToMV resistance protein TM-2(2), AC Q71BG9) (By similarity).
CC       {ECO:0000250|UniProtKB:P03583, ECO:0000250|UniProtKB:P69513}.
CC   -!- SIMILARITY: Belongs to the tobamovirus movement protein family.
CC       {ECO:0000305}.
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DR   EMBL; AJ132845; CAB36999.1; -; Genomic_RNA.
DR   EMBL; AJ011934; CAA09878.1; -; Genomic_RNA.
DR   Proteomes; UP000008254; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001022; TMV_movement.
DR   InterPro; IPR028919; Viral_movement.
DR   Pfam; PF01107; MP; 1.
DR   PRINTS; PR00964; MOVEMENT.
PE   3: Inferred from homology;
KW   Host cell junction; Host cytoplasm; Host cytoskeleton; RNA-binding;
KW   Transport; Viral movement protein.
FT   CHAIN           1..264
FT                   /note="Movement protein"
FT                   /id="PRO_0000144973"
FT   REGION          211..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..264
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   264 AA;  29261 MW;  018394057CA46FAB CRC64;
     MALVVKGKVN INEFIDLSKS EKLLPSMFTP VKSVMVSKVD KIMVHENESL SEVNLLKGVK
     LIEGGYVCLV GLVVSGEWNL PDNCRGGVSV CLVDKRMERA DEATLGSYYT AAAKKRFQFK
     VVPNYGITTK DAEKNIWQVL VNIKNVKMSA GYCPLSLEFV SVCIVYKNNT KLGLREKVTS
     VNDGGPMELS EEVVDEFMEN VPMSVRLAKF RTKSSKRGPK NNNNLGKGRS GGRPKPKSFD
     EVEKEFDNLI EDEAETSVAD SDSY
 
 
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