MVP_TOMS1
ID MVP_TOMS1 Reviewed; 264 AA.
AC Q9YJQ9;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Movement protein;
DE AltName: Full=30 kDa protein;
DE AltName: Full=Cell-to-cell transport protein;
GN Name=MP;
OS Tomato mosaic virus (strain S-1) (ToMV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Martellivirales; Virgaviridae; Tobamovirus.
OX NCBI_TaxID=138314;
OH NCBI_TaxID=4151; Antirrhinum majus (Garden snapdragon).
OH NCBI_TaxID=4071; Capsicum (peppers).
OH NCBI_TaxID=46246; Delphinium.
OH NCBI_TaxID=4101; Petunia.
OH NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH NCBI_TaxID=13707; Tagetes (marigolds).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA Zhou X., Xue C., Chen Q., Qi Y., Li D.;
RT "Complete nucleotide sequence of a Chinese isolate of tomato mosaic
RT virus.";
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-200.
RA Zhou X., Xue C., Qi Y., Li D.;
RT "Isolation and nucleotide sequence of the 30k and the coat protein cistron
RT of a Chinese isolate of tomato mosaic virus.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC through plasmosdesmata, without any budding. The movement protein
CC allows efficient cell to cell propagation, by bypassing the host cell
CC wall barrier. Forms a ribonucleoprotein complex with viral RNA. Binds
CC microtubules and modulates microtubule stability. Can bind double-
CC stranded DNA. Triggers host hypersensitive defense reaction in
CC incompatible plants harboring resistance (R) proteins.
CC {ECO:0000250|UniProtKB:P03583, ECO:0000250|UniProtKB:P69513}.
CC -!- SUBUNIT: Binds to host RBCS at the plasmodesmata; this interaction
CC seems required for viral systemic movement (By similarity). In
CC resistant plants, interacts with host MBP2C at host microtubules; this
CC interaction prevents virus cell to cell movement. In resistant plants,
CC interacts with host resistance (R) protein (e.g. tomato ToMV resistance
CC protein TM-2(2), AC Q71BG9) at the host plasma membrane; this
CC interaction triggers host defense responses leading to programmed cell
CC death (By similarity). {ECO:0000250|UniProtKB:A0A0S4IJL0,
CC ECO:0000250|UniProtKB:P03583, ECO:0000250|UniProtKB:P69513}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytoskeleton
CC {ECO:0000250|UniProtKB:P69513}. Host cell junction, host plasmodesma
CC {ECO:0000250|UniProtKB:P69513}. Note=Binds to the host cytoskeleton
CC before being transported to the host plasmodesmata. Observed in virus
CC replication complexes (VRCs) of tobamovirus infected host cells (By
CC similarity). In resistant plants, targeted to the host plasma membrane
CC via the interaction with host resistance (R) protein TM-2 (e.g. tomato
CC ToMV resistance protein TM-2(2), AC Q71BG9) (By similarity).
CC {ECO:0000250|UniProtKB:P03583, ECO:0000250|UniProtKB:P69513}.
CC -!- SIMILARITY: Belongs to the tobamovirus movement protein family.
CC {ECO:0000305}.
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DR EMBL; AJ132845; CAB36999.1; -; Genomic_RNA.
DR EMBL; AJ011934; CAA09878.1; -; Genomic_RNA.
DR Proteomes; UP000008254; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR InterPro; IPR001022; TMV_movement.
DR InterPro; IPR028919; Viral_movement.
DR Pfam; PF01107; MP; 1.
DR PRINTS; PR00964; MOVEMENT.
PE 3: Inferred from homology;
KW Host cell junction; Host cytoplasm; Host cytoskeleton; RNA-binding;
KW Transport; Viral movement protein.
FT CHAIN 1..264
FT /note="Movement protein"
FT /id="PRO_0000144973"
FT REGION 211..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..264
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 29261 MW; 018394057CA46FAB CRC64;
MALVVKGKVN INEFIDLSKS EKLLPSMFTP VKSVMVSKVD KIMVHENESL SEVNLLKGVK
LIEGGYVCLV GLVVSGEWNL PDNCRGGVSV CLVDKRMERA DEATLGSYYT AAAKKRFQFK
VVPNYGITTK DAEKNIWQVL VNIKNVKMSA GYCPLSLEFV SVCIVYKNNT KLGLREKVTS
VNDGGPMELS EEVVDEFMEN VPMSVRLAKF RTKSSKRGPK NNNNLGKGRS GGRPKPKSFD
EVEKEFDNLI EDEAETSVAD SDSY