MVP_TRYB2
ID MVP_TRYB2 Reviewed; 838 AA.
AC Q57Z03; D6XH30;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Major vault protein;
GN ORFNames=Tb927.5.4460;
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000312|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C.M., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
CC -!- FUNCTION: Required for normal vault structure. Vaults are multi-subunit
CC structures that may act as scaffolds for proteins involved in signal
CC transduction. Vaults may also play a role in nucleo-cytoplasmic
CC transport (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The vault ribonucleoprotein particle is a huge (400 A x 670 A)
CC cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with
CC each half-vault comprising 39 identical major vault protein (MVP)
CC chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14764}. Nucleus
CC {ECO:0000250|UniProtKB:Q14764}.
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DR EMBL; AC116668; AAX80595.1; -; Genomic_DNA.
DR EMBL; CP000068; AAZ11557.1; -; Genomic_DNA.
DR RefSeq; XP_845116.1; XM_840023.1.
DR AlphaFoldDB; Q57Z03; -.
DR SMR; Q57Z03; -.
DR STRING; 5691.AAZ11557; -.
DR PaxDb; Q57Z03; -.
DR GeneID; 3657553; -.
DR KEGG; tbr:Tb927.5.4460; -.
DR VEuPathDB; TriTrypDB:Tb927.5.4460; -.
DR eggNOG; ENOG502QPP0; Eukaryota.
DR InParanoid; Q57Z03; -.
DR OMA; VIRIKRY; -.
DR Proteomes; UP000008524; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR CDD; cd08825; MVP_shoulder; 1.
DR Gene3D; 2.30.30.550; -; 4.
DR Gene3D; 2.30.30.560; -; 2.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR039059; MVP.
DR InterPro; IPR041139; MVP_rep_dom.
DR InterPro; IPR043023; MVP_rep_sf.
DR InterPro; IPR021870; MVP_shoulder.
DR InterPro; IPR041134; Vault_2.
DR InterPro; IPR043179; Vault_2_sf.
DR InterPro; IPR040989; Vault_3.
DR InterPro; IPR041136; Vault_4.
DR InterPro; IPR002499; Vault_N.
DR PANTHER; PTHR14165; PTHR14165; 1.
DR Pfam; PF11978; MVP_shoulder; 1.
DR Pfam; PF01505; Vault; 4.
DR Pfam; PF17794; Vault_2; 2.
DR Pfam; PF17795; Vault_3; 1.
DR Pfam; PF17796; Vault_4; 1.
DR PROSITE; PS51224; MVP; 7.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Ribonucleoprotein.
FT CHAIN 1..838
FT /note="Major vault protein"
FT /id="PRO_0000414611"
FT REPEAT 13..52
FT /note="MVP 1"
FT REPEAT 53..114
FT /note="MVP 2"
FT REPEAT 118..170
FT /note="MVP 3"
FT REPEAT 171..223
FT /note="MVP 4"
FT REPEAT 224..278
FT /note="MVP 5"
FT REPEAT 280..328
FT /note="MVP 6"
FT REPEAT 329..381
FT /note="MVP 7"
FT REPEAT 382..426
FT /note="MVP 8"
SQ SEQUENCE 838 AA; 94103 MW; 9EC75A5291216709 CRC64;
MSDIIRIKRH FYVHLLNNNT NVTKCMLGPQ VYTRKEHERC LFEPRQCVVV PPGHYCVVQN
PCVRGEDNIP KVGESEEVQL RMGEKEIRFE QPPFPLLPGE ELLTVDGEWL FKLKVIPSNK
GYHVRCTRDF VDSTRVSVRA GEQWIVEGPQ TFIPRVEVEE LGEVEALTVE SNTAIKLRAR
LNFTDRQGVA RVAGEEWLHR TSGAYLPAYE EEFVSYVRGA VLTEKEAIHL RALRNFTDVY
GKARKAGEQW MITHKMSSTH IPDVNEVITA TVNAIILSKN QYCIVKDPVG DEGINQFGKR
EVRKGECSFF LRPGESLVGE VQSMNAIGKN EALLLQALEK FEDCGGTVRM PGEKWLLRGA
TEYIPRVDVC VLERRGVIAL DKNEGIYVMN TTTGEVRTVI GEPYMLKEHE VLWEKDLSPD
VEELLACPTG CCRCSERDPN FTSSRVKHRI IRFNVQHNAA VQIYDYKQKK PRVVLGPNLV
MLSPDEEFTV LSLSGGKPKA LNSLLALQLF LGPRFSSDTI VVETSDHARL QLSLSYNWHF
DVNRENPDAK IFSVPDFVGD CCKTIASRVR GAVAAEDFDS FHRNSAKIIR EAVFGRDGNG
HVRNSLRFSA NNLVVTNIDI QSVEPTDAKT RDSLQKSVQL AIEITTKSQE AAARHGKERK
DQEARGRLER QKLVDKIEVE RTKTQWLELQ AQSEVVQASG QAVAEAKAKA ESLLIEADTE
LKQAEMRAKA LRITAASDLA KQKQQQDLEL EFAKRQNELE IVKARELAQT EVERIQRMVS
AIGRQTLVSI AQAGPEMQAK LLGGLGLKGY LITDGKTPVN LFNTAQGMLG GQTTETKS
