MVP_TRYCC
ID MVP_TRYCC Reviewed; 838 AA.
AC Q4CUM2;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 51.
DE RecName: Full=Major vault protein;
GN ORFNames=Tc00.1047053510353.10;
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153;
RN [1] {ECO:0000312|EMBL:EAN83972.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000312|EMBL:EAN83972.1};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M.A., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.-N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- FUNCTION: Required for normal vault structure. Vaults are multi-subunit
CC structures that may act as scaffolds for proteins involved in signal
CC transduction. Vaults may also play a role in nucleo-cytoplasmic
CC transport (By similarity). {ECO:0000250|UniProtKB:Q14764}.
CC -!- SUBUNIT: The vault ribonucleoprotein particle is a huge (400 A x 670 A)
CC cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with
CC each half-vault comprising 39 identical major vault protein (MVP)
CC chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).
CC {ECO:0000250|UniProtKB:Q14764}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14764,
CC ECO:0000255|PROSITE-ProRule:PRU00571}. Nucleus
CC {ECO:0000250|UniProtKB:Q14764}.
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DR EMBL; AAHK01001837; EAN83972.1; -; Genomic_DNA.
DR RefSeq; XP_805823.1; XM_800730.1.
DR AlphaFoldDB; Q4CUM2; -.
DR SMR; Q4CUM2; -.
DR STRING; 5693.XP_805823.1; -.
DR PaxDb; Q4CUM2; -.
DR EnsemblProtists; EAN83972; EAN83972; Tc00.1047053510353.10.
DR GeneID; 3535684; -.
DR KEGG; tcr:510353.10; -.
DR eggNOG; ENOG502QPP0; Eukaryota.
DR OMA; VIRIKRY; -.
DR OrthoDB; 256008at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd08825; MVP_shoulder; 1.
DR Gene3D; 2.30.30.550; -; 4.
DR Gene3D; 2.30.30.560; -; 2.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR039059; MVP.
DR InterPro; IPR041139; MVP_rep_dom.
DR InterPro; IPR043023; MVP_rep_sf.
DR InterPro; IPR021870; MVP_shoulder.
DR InterPro; IPR041134; Vault_2.
DR InterPro; IPR043179; Vault_2_sf.
DR InterPro; IPR040989; Vault_3.
DR InterPro; IPR041136; Vault_4.
DR InterPro; IPR002499; Vault_N.
DR PANTHER; PTHR14165; PTHR14165; 1.
DR Pfam; PF11978; MVP_shoulder; 1.
DR Pfam; PF01505; Vault; 4.
DR Pfam; PF17794; Vault_2; 2.
DR Pfam; PF17795; Vault_3; 1.
DR Pfam; PF17796; Vault_4; 1.
DR PROSITE; PS51224; MVP; 7.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Ribonucleoprotein.
FT CHAIN 1..838
FT /note="Major vault protein"
FT /id="PRO_0000414612"
FT REPEAT 13..52
FT /note="MVP 1"
FT /evidence="ECO:0000255"
FT REPEAT 53..114
FT /note="MVP 2"
FT /evidence="ECO:0000255"
FT REPEAT 118..170
FT /note="MVP 3"
FT /evidence="ECO:0000255"
FT REPEAT 171..223
FT /note="MVP 4"
FT /evidence="ECO:0000255"
FT REPEAT 224..278
FT /note="MVP 5"
FT /evidence="ECO:0000255"
FT REPEAT 280..328
FT /note="MVP 6"
FT /evidence="ECO:0000255"
FT REPEAT 329..380
FT /note="MVP 7"
FT /evidence="ECO:0000255"
FT REPEAT 381..433
FT /note="MVP 8"
FT /evidence="ECO:0000255"
SQ SEQUENCE 838 AA; 94525 MW; D62F33E6D4029BD6 CRC64;
MGDIIRIKRH HYVHILDNNT NVTRCMVGPL VYTRKENERC LFNPKPCIVV PPRFYCIVQN
PCVRDASGNP VIGENSSVML RMGEEEICFE QEPFPLQPGE VLKREEEEWL FKLKLIPVNT
GYHVRCLCDF TDKNSVLRRA GTEWLVEGPQ TYVPRVEVEV LREVHAHIIS PNTALHIRAL
VKFTDRTGVP REAGDLWTVR TVGAYLPAVE EDVIGTFQGI TLTDTEAVHL EALSNFTDVY
GKRRRAGERW LVTKEDASIH IPDVHEKVSG KVRAIVLNEK EYCVVQNPLG ADGLNEFGRK
EVRKGECRFF LHPQEELLGG MQPINVVSKD QALLLQAVDF FDDNGKIRRP GEKWMLHGPA
EYIPDVNVRI LEQRNLIALD KNEGIYVMNT TTGVVRVVIG KPYMLNENEV LWEKDLSPKV
EELLAFANGC MSEGERNPSF KSTRVRHRVV RFNVQHNAAV QIYDYKQKKL RVVLGPNLVI
LSPDEEFTVV SLSGGKPKVP NLLHCLQLFL GPRFSSDRIV VETSDHARLE LDLSYNWYFD
VNREEPDAKI FSVPDFIGDC CKTIASRIRG AVAAEDFDSF HRNSAKIIRV AVFGRGENGE
INTSLRFSAN NLVVTNIDIQ SVEPTDAKTR DSLQKSVQLA IEITTKSQEA AARHGKERKD
QEARGKLERQ KLLDKIEVER TKTKWLQLQA QSEAVQASGQ SVAEAKAKAE SLLIEVDSEL
KQAEMRAKAY RITAESELKK QKQKLELELE FTKRQNELDI MKARQIAETE AERVQRMVNA
IGRETIVAVA QAGPEMQAKL LGGLGLKGYL ITDGKSPVNL FNTAQGLIDA GSSAQEHS
