ID   MVP_XENLA               Reviewed;         849 AA.
AC   Q6PF69;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Major vault protein;
DE            Short=MVP;
GN   Name=mvp;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for normal vault structure. Vaults are multi-subunit
CC       structures that may act as scaffolds for proteins involved in signal
CC       transduction. Vaults may also play a role in nucleo-cytoplasmic
CC       transport (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The vault ribonucleoprotein particle is a huge (400 A x 670 A)
CC       cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with
CC       each half-vault comprising 39 identical major vault protein (MVP)
CC       chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14764}. Nucleus
CC       {ECO:0000250|UniProtKB:Q14764}.
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DR   EMBL; BC057708; AAH57708.1; -; mRNA.
DR   RefSeq; NP_001079939.1; NM_001086470.1.
DR   AlphaFoldDB; Q6PF69; -.
DR   SMR; Q6PF69; -.
DR   BioGRID; 97873; 1.
DR   IntAct; Q6PF69; 1.
DR   DNASU; 379630; -.
DR   GeneID; 379630; -.
DR   KEGG; xla:379630; -.
DR   CTD; 379630; -.
DR   Xenbase; XB-GENE-5880964; mvp.L.
DR   OrthoDB; 256008at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 379630; Expressed in intestine and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd08825; MVP_shoulder; 1.
DR   Gene3D; 2.30.30.550; -; 4.
DR   Gene3D; 2.30.30.560; -; 2.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR039059; MVP.
DR   InterPro; IPR041139; MVP_rep_dom.
DR   InterPro; IPR043023; MVP_rep_sf.
DR   InterPro; IPR021870; MVP_shoulder.
DR   InterPro; IPR041134; Vault_2.
DR   InterPro; IPR043179; Vault_2_sf.
DR   InterPro; IPR040989; Vault_3.
DR   InterPro; IPR041136; Vault_4.
DR   InterPro; IPR002499; Vault_N.
DR   PANTHER; PTHR14165; PTHR14165; 1.
DR   Pfam; PF11978; MVP_shoulder; 1.
DR   Pfam; PF01505; Vault; 4.
DR   Pfam; PF17794; Vault_2; 2.
DR   Pfam; PF17795; Vault_3; 1.
DR   Pfam; PF17796; Vault_4; 1.
DR   PROSITE; PS51224; MVP; 8.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; Ribonucleoprotein.
FT   CHAIN           1..849
FT                   /note="Major vault protein"
FT                   /id="PRO_0000247491"
FT   REPEAT          2..55
FT                   /note="MVP 1"
FT   REPEAT          56..110
FT                   /note="MVP 2"
FT   REPEAT          111..162
FT                   /note="MVP 3"
FT   REPEAT          163..215
FT                   /note="MVP 4"
FT   REPEAT          216..270
FT                   /note="MVP 5"
FT   REPEAT          271..321
FT                   /note="MVP 6"
FT   REPEAT          322..378
FT                   /note="MVP 7"
FT   REPEAT          379..454
FT                   /note="MVP 8"
FT   REPEAT          455..517
FT                   /note="MVP 9"
FT   REGION          430..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..452
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   849 AA;  95670 MW;  F48B187D7471CBB8 CRC64;
     MSEESIIRIP PYCYIHVLDQ NSNISRVETG PKTYIRQDNE RVLHHPQRMV MVPPRHYCVI
     QNPVQRDSEE KVLFDDVGQA KLSHGDKEIR LTQDPFPLYP GEELQLGITP LTVVLANTAL
     HLKALLDLED ESGKYVAGDE WLFEGPGTYI PRKEVEVVQT IQATVIRHNQ AIRLRARKEC
     KDREEQDRVT GEEWLVKKVG AYLPGVFEEV VDIVDAFVLT DKRALHIRAT KTFRGDKGNL
     RRTGEEWLVT MEDTEAYIPN VYEEVVGVVD ITTLNSRQYC VILDPVGEDG KPQLGQKRVV
     KGEKSFFLQP GESLEYGIQD VYILSEEEGL VLRALQVLED KDEEGTEVER KPGDRWMIRG
     PIEYAPPVEV EVVVRREAIP LDENEGIYVR DIKTGKVRAV VGQSYMLTQD EELWEKELPA
     NVETLLASGK DPLADRSERQ GQAQEVQPRD KTRAVTYRVP HNAAVQVYDY REKKSRVVFG
     PELVVLGPDE QFTVLSLSGS TPKRANVIKA ICLLLGPDFC TDIINIETAD HARLQIKLSY
     NWHFDIKDRK DPAEASKLFT VPDFVGDACK AIASRIRGAV ASVQFDDFHK NSNRIICSAV
     FGFDEAMKIR NSFRFPQNNL IITSVDIQTV EPVDQRTRDA LQKSVQLAIE ITTNSQEATA
     RHEAERLEQE AKGRLERQRI TDQAEAEKAR KELLELEALS TIVESTGAAK AEAESKAEAA
     RIEGEGAVLQ AKLRAEALAI ETDAELQRLR QARSEELRYL QDKNKLEVQK TQELAEIEIK
     KFREMVESIG SGTLRDIALA GPELQVKMLR GLGIQSTLIT DGSTPINLFS TAHGLLGLTS
     KPAQEKESD