ID   MX1_ICTPU               Reviewed;         635 AA.
AC   Q7T2P0;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Interferon-induced GTP-binding protein Mx1;
DE   AltName: Full=Interferon-inducible Mx1 protein;
GN   Name=mx1; Synonyms=mx;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=15123306; DOI=10.1016/j.fsi.2003.07.001;
RA   Plant K.P., Thune R.L.;
RT   "Cloning and characterisation of a channel catfish (Ictalurus punctatus) Mx
RT   gene.";
RL   Fish Shellfish Immunol. 16:391-405(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By interferons.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
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DR   EMBL; AY095349; AAM23274.1; -; mRNA.
DR   RefSeq; NP_001187103.1; NM_001200174.1.
DR   AlphaFoldDB; Q7T2P0; -.
DR   SMR; Q7T2P0; -.
DR   PRIDE; Q7T2P0; -.
DR   GeneID; 100304594; -.
DR   KEGG; ipu:100304594; -.
DR   CTD; 360142; -.
DR   OMA; IGCKETV; -.
DR   OrthoDB; 494748at2759; -.
DR   Proteomes; UP000221080; Chromosome 26.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; PTHR11566; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding.
FT   CHAIN           1..635
FT                   /note="Interferon-induced GTP-binding protein Mx1"
FT                   /id="PRO_0000292873"
FT   DOMAIN          31..309
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   DOMAIN          549..635
FT                   /note="GED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT   REGION          41..48
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          66..68
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          147..150
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          216..219
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          248..251
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   BINDING         41..48
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         147..151
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         216..219
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   635 AA;  72585 MW;  40094B7F04B036E4 CRC64;
     MSASLSEQYE EKVRPCIDLI DSLRALGVEK DLALPAIAVI GDQSSGKSSV LEALSGVALP
     RGSGIVTRCP LELKMKRSRE EDFWHGKIKY KKDHDEDYEE EIQNPADVEK KIREAQDHMA
     GVGVGISDEL ISLEVTSADV PDLTLIDLPG IARVAVKGQP ENIGEQIKRL IKKFITKQET
     INLVVVPSNV DIATTEALKM AQEVDPNGER TLGILTKPDL VDKGTEETVV SIIHNEIIYL
     TKGYMIVRCR GQKEIMDRVS LHEATEKEKD FFKDHPHFST LYEEGMATIP NLAEKLTLEL
     VHHIELSLPR LEEQIDIKLA DSQAELDRYG SGPPTEPAER ICFLIDKVTA FTQDTINLTT
     GEELKNIQHL NIFSSLRRQF ALWKMHLDDS GETFKSRIEK EVNEYEEKYR GRELPGFINY
     KTFEVIVKDQ IKQLEEPAIR RLKEISDLIR KGFIQLAQNS FLGFPNLLKM AKTKIECIKQ
     VKESEAETML RTQFKMELII YTQDSMYSDT LSTLKVKEEE GERQKVGILP NSYSISCSLY
     NHSNNRATLE ELMRHLKSYY SIASKRLADQ LPLVIRYLLL QESAAQLQRE MLQLMQDKNA
     IDHLLKEDHD IGNKRNNLQS RQKRLMEARN YLVKF