ID   MX2_ICTPU               Reviewed;         625 AA.
AC   Q4U4N4;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Interferon-induced GTP-binding protein Mx2;
DE   AltName: Full=Interferon-inducible Mx2 protein;
GN   Name=mx2;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Plant K.P., Thune R.L.;
RT   "Cloning and sequencing of channel catfish Mx2.";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By interferons.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
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DR   EMBL; DQ011854; AAY33864.1; -; mRNA.
DR   RefSeq; NP_001187140.1; NM_001200211.1.
DR   AlphaFoldDB; Q4U4N4; -.
DR   SMR; Q4U4N4; -.
DR   PRIDE; Q4U4N4; -.
DR   GeneID; 100304652; -.
DR   KEGG; ipu:100304652; -.
DR   CTD; 4600; -.
DR   OrthoDB; 494748at2759; -.
DR   Proteomes; UP000221080; Chromosome 26.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; PTHR11566; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding.
FT   CHAIN           1..625
FT                   /note="Interferon-induced GTP-binding protein Mx2"
FT                   /id="PRO_0000292874"
FT   DOMAIN          29..302
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   DOMAIN          539..625
FT                   /note="GED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT   REGION          39..46
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          64..66
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          140..143
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          209..212
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          241..244
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   BINDING         39..46
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         140..144
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         209..212
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   625 AA;  71849 MW;  53AF9C39EC71BA37 CRC64;
     MSLSEQYEEK VRPCIDLIDS LRALGVEKDL ALPAIAVIGD QSSGKSSVLE ALSGVALPRG
     SGIVTRCPLE LKMKKSRKAD FWHGKIKYED YEEEIEDPAD VEQMIRKAQN EIAGTGMGIS
     DKLISLEVTS SNVPDLTVID LPGITRVAVK DQPENIGDQS KRLIKKFITK QETINLVVVP
     CNVDIATTEA LKMALEVDPN GERTFGVLTK PDLVDKGSEE TVVSIINNEI VYLNKGYIIV
     RCRGQQEIKD RVSLNETVKR ERDFFEDHPH FRTLYDNRKA TIPNLAEKLT LELVFHIGRC
     LPRLEERIQV KLSETQAELD RYGSGTPTEP EQRIYFLTDK ITAFIQDVLN LTTGEEVKSM
     LYMNIFPDLR KQFDLWKNDL DSVGETFNKK IEKEMKAYEE KYRGRELPGF LKYNTFEVIV
     KGQIKQLEEP AIRRLKEISD LIKREFSQLA HSNFPGFPNI LKMAKTKIDN IKQVKESETE
     SILRTQFKME MMIYTQDKTH HDNLKMLKSK EEGKERQKLG VAHSPSHKLY DHSDSEGIRE
     ELTCHLKSYF SIVTKRLADQ VPMVIRYMML QESAAQLQRE MIQLIQDRHN IEELLKEDHD
     IASKRNNLHS CQKRLTEALK YLAKF