MX2_SHEEP
ID MX2_SHEEP Reviewed; 714 AA.
AC Q5I2P5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Interferon-induced GTP-binding protein Mx2;
DE AltName: Full=Myxovirus resistance protein 2;
GN Name=MX2;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Endometrium;
RA Assiri A.M., Welker J.E., Ott T.L.;
RT "Cloning and characterization of a second Mx gene (Mx2) from pregnant sheep
RT endometrium.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP REVIEW, AND INDUCTION.
RX PubMed=18062906; DOI=10.1016/j.micinf.2007.09.010;
RA Haller O., Stertz S., Kochs G.;
RT "The Mx GTPase family of interferon-induced antiviral proteins.";
RL Microbes Infect. 9:1636-1643(2007).
CC -!- FUNCTION: Interferon-induced dynamin-like GTPase with antiviral
CC activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- INDUCTION: By type I and type III interferons.
CC {ECO:0000269|PubMed:18062906}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC ProRule:PRU01055}.
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DR EMBL; AY859475; AAW51454.1; -; mRNA.
DR RefSeq; NP_001072120.1; NM_001078652.1.
DR AlphaFoldDB; Q5I2P5; -.
DR SMR; Q5I2P5; -.
DR STRING; 9940.ENSOARP00000010974; -.
DR PRIDE; Q5I2P5; -.
DR GeneID; 780441; -.
DR KEGG; oas:780441; -.
DR CTD; 4600; -.
DR eggNOG; KOG0446; Eukaryota.
DR OrthoDB; 494748at2759; -.
DR Proteomes; UP000002356; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; PTHR11566; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cytoplasm; GTP-binding; Immunity; Innate immunity;
KW Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..714
FT /note="Interferon-induced GTP-binding protein Mx2"
FT /id="PRO_0000319960"
FT DOMAIN 115..386
FT /note="Dynamin-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT DOMAIN 622..713
FT /note="GED"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..132
FT /note="G1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 150..152
FT /note="G2 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 224..227
FT /note="G3 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 293..296
FT /note="G4 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 325..328
FT /note="G5 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT COMPBIAS 47..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 125..132
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 224..228
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 293..296
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
SQ SEQUENCE 714 AA; 81681 MW; 508911B89A61BC06 CRC64;
MSMSYRALKF RRHAPTSTQH HPKEDMNFHQ QPPGLPGPAL GQTMSPPPWQ MGESNPDFLP
NNFNQLNLDP QQPEADGGQQ RSKGSENNLY RKYEEKVRPC IDLIDSLRAL GVEQDLALPA
IAVIGDQSSG KSSVLEALSG VALPRGSGII TRCPLVLKLT KRECEWTGKI TYRNVTQQLH
NPSEVEREIR RAQNIIAGNG VGISHELINL EVTSPEVPDL TLIDLPGITR VAVENQPQDI
GLQIKALIKT YIQRQETINL VVVPCNVDIA TTEALSMAQE VDPDGDRTIG ILTKPDLVDK
GTEKGVLKVM QNLTYHLKKG YMIVKCRGQQ DITNKLSLAE ATRKEVMFFQ THPYFRVLLD
EGKATVPLLA ERLTTELIWH INKSLPLLEN QIKEKHQRAT EELQQYGDDI PSNEGDKMFF
LIEKIKLFNE DIEKLIEGEE IVIETESRLC NRIREEFTRW VLILTTNIEK VKSILNEEVS
KYETKYRGKE LLGFVNYKTF ETVVKHYLGQ LIDPALKMLQ KAMEIIWQTF KDTAKKHFAE
FCNLHQTVQN KIEDIKTKQM AEAANLIQLQ FRMEKLVFCQ DQIYGVVLNK VREEIFNSVG
KASENPQSKH PFLNNQSSVS SIVEIGVHLN AYFTETSKRL ANQIPFIIQY FMLQENGDKV
QKAMMQLLQE TQHYSWLLQE QSDTATKRKF LKEKIFRLTQ AQQALYEFPH FKSI
