ID   MX3_RAT                 Reviewed;         659 AA.
AC   P18590;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Interferon-induced GTP-binding protein Mx3;
DE   AltName: Full=Myxovirus resistance protein 3;
GN   Name=Mx3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2173790; DOI=10.1128/jvi.64.12.6263-6269.1990;
RA   Meier E., Kunz G., Haller O., Arnheiter H.;
RT   "Activity of rat Mx proteins against a rhabdovirus.";
RL   J. Virol. 64:6263-6269(1990).
CC   -!- FUNCTION: Does not show activity against influenza virus or VSV;
CC       although it only differs from Mx2 by 8 positions.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- INDUCTION: By interferons.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X52713; CAA36937.1; -; mRNA.
DR   PIR; S11737; S11737.
DR   AlphaFoldDB; P18590; -.
DR   SMR; P18590; -.
DR   STRING; 10116.ENSRNOP00000002695; -.
DR   PaxDb; P18590; -.
DR   UCSC; RGD:628821; rat.
DR   RGD; 621298; Mx3.
DR   eggNOG; KOG0446; Eukaryota.
DR   InParanoid; P18590; -.
DR   PhylomeDB; P18590; -.
DR   PRO; PR:P18590; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; PTHR11566; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..659
FT                   /note="Interferon-induced GTP-binding protein Mx3"
FT                   /id="PRO_0000206601"
FT   DOMAIN          65..338
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   DOMAIN          571..659
FT                   /note="GED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT   REGION          75..82
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          100..102
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          176..179
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          245..248
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          277..280
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          547..568
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         75..82
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         176..180
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         245..248
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   659 AA;  74952 MW;  F55D63283BC865B3 CRC64;
     MVLSTEENRS VDLVNLPSVP LPDGEAGVGE NNKDSVNNLC SQYEEKVRPC IDLIDSLRAL
     GVEQDLALPA IAVIGDQSSG KSSVLEALSG VALPRGSGIV TRCPLVLKLK KLNQGEEWKG
     KVTYDDIEVE LSDPSEVEEA INTGQNHIAG VGLGISDKLI SLDVSSPHVP DLTLIDLPGI
     TRVAVGNQPS DIGRQIKRLI TNYIQKQETI NLVVVPSNVD IATTEALSMA QEVDPDGDRT
     IGILTKPDLV DRGTEDKVVD VVRNLVCHLK KGYMIVKCRG QQDIQEQLSL AEALQKEQVF
     FKEHPQFRAL LEDGKATVPC LAERLTMELI SHICKSLPLL ENQIKESHQS TSEELQKYGA
     DIPEDENEKT LFLIEKINAF NQDITAIVEG EEIVREKECR LFTKLRKEFF LWSEEIERNF
     QKGSDALYKE VYTFEMQYRG RELPGFVNYK TFENIIRRQI KTLEEPAMEM LHKVTEIVRA
     AFTTVSEKNF SEFFNLHRTT KSKLEDIRLE QETEAEKAIR LHFQMEQIIY CQDQIYRKAL
     QKVREEEAEE EERKHGKSRS AQSPNLQTSS MDEIFQHLNA YRQEAHNCIS SHIPLIIQYF
     ILKMFAEKLQ KGMLQLLQDK DSCSWLLKEK SDTSEKRRFL KERLARLAQA QRRLAKFPG