ID   MXB_DANRE               Reviewed;         627 AA.
AC   Q800G8;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Interferon-induced GTP-binding protein MxB;
DE   AltName: Full=IFN-inducible antiviral protein MxB;
DE   AltName: Full=Interferon-inducible MxB protein;
GN   Name=mxb;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12869211; DOI=10.1186/1471-2164-4-29;
RA   Lutfalla G., Roest Crollius H., Stange-Thomann N., Jaillon O., Mogensen K.,
RA   Monneron D.;
RT   "Comparative genomic analysis reveals independent expansion of a lineage-
RT   specific gene family in vertebrates: the class II cytokine receptors and
RT   their ligands in mammals and fish.";
RL   BMC Genomics 4:29-29(2003).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By interferons.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
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DR   EMBL; AJ544824; CAD67756.2; -; mRNA.
DR   AlphaFoldDB; Q800G8; -.
DR   SMR; Q800G8; -.
DR   STRING; 7955.ENSDARP00000100431; -.
DR   PaxDb; Q800G8; -.
DR   ZFIN; ZDB-GENE-030721-6; mxb.
DR   eggNOG; KOG0446; Eukaryota.
DR   InParanoid; Q800G8; -.
DR   PhylomeDB; Q800G8; -.
DR   PRO; PR:Q800G8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR   GO; GO:0009615; P:response to virus; IDA:ZFIN.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; PTHR11566; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..627
FT                   /note="Interferon-induced GTP-binding protein MxB"
FT                   /id="PRO_0000292868"
FT   DOMAIN          34..307
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   DOMAIN          541..627
FT                   /note="GED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT   REGION          44..51
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          69..71
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          145..148
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          214..217
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          246..249
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   BINDING         44..51
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         145..149
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         214..217
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   627 AA;  71287 MW;  11A80DA1614AA916 CRC64;
     MEKMSYTFSQ QYEEKIRPCI DTIDNLRSLG VEKDLALPAI AVIGDQSSGK SSVLEALSGV
     PLPRGSGIVT RCPLELKMIR SKEDEKWHGR ISYQNHEEDF DDPAEVEKKI REAQDEMAGA
     GVGISEELIS LQITSANVPD LTLIDLPGIA RVAVKGQPEN IGDQIKRLIR MFITKQETIN
     LVVVPCNVDI ATTEALQMAQ AEDPEGERTL GILTKPDLVD KGTEGTVVDI VHNEVIHLTK
     GYMIVRCRGQ KEIMDQVTLN EATETESAFF KDHPHFRKLY EEGFATIPKL AEKLTIELVH
     HIQRSLPRLE DQIQTKLAET QKELEAYGDG PPSDPAERLS FFIDKVTAFT CDTLNLTTGE
     EVKSASKLLI FPELRQEFAY WNSFLDSSGY SFKLKIEEEV DNYEVKYRGR ELPGFINYKT
     FEGLVREQMK LLEEPALKML KNVSDMVKKK FIQLAQSSFT GFPILLKIAK TKIEAIKQDK
     ECLAESMLRT QFKMELIVYT QDGTYSQSLL RSKEKREEDE EDTENFDCMT VGIATSNHAT
     LSEMKLHLES YYMIASQRLA DQIPMVIRYL LLQEAALELQ RSMLQLLQDK DGVDDMLKED
     FDIGQKRENL LSRQKRLMKA QNLLATY