MXC_DANRE
ID MXC_DANRE Reviewed; 626 AA.
AC Q6DKF0; Q800G7;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Interferon-induced GTP-binding protein MxC;
DE AltName: Full=IFN-inducible antiviral protein MxC;
DE AltName: Full=Interferon-inducible MxC protein;
GN Name=mxc;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 29-309.
RX PubMed=12869211; DOI=10.1186/1471-2164-4-29;
RA Lutfalla G., Roest Crollius H., Stange-Thomann N., Jaillon O., Mogensen K.,
RA Monneron D.;
RT "Comparative genomic analysis reveals independent expansion of a lineage-
RT specific gene family in vertebrates: the class II cytokine receptors and
RT their ligands in mammals and fish.";
RL BMC Genomics 4:29-29(2003).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- INDUCTION: By interferons.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC ProRule:PRU01055}.
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DR EMBL; BC074099; AAH74099.1; -; mRNA.
DR EMBL; AJ544825; CAD67757.1; -; mRNA.
DR RefSeq; NP_001007285.1; NM_001007284.2.
DR RefSeq; XP_005167728.1; XM_005167671.3.
DR AlphaFoldDB; Q6DKF0; -.
DR SMR; Q6DKF0; -.
DR STRING; 7955.ENSDARP00000007267; -.
DR PaxDb; Q6DKF0; -.
DR Ensembl; ENSDART00000012694; ENSDARP00000007267; ENSDARG00000024789.
DR GeneID; 360145; -.
DR KEGG; dre:360145; -.
DR CTD; 360145; -.
DR ZFIN; ZDB-GENE-030721-7; mxc.
DR eggNOG; KOG0446; Eukaryota.
DR GeneTree; ENSGT00940000164201; -.
DR InParanoid; Q6DKF0; -.
DR OrthoDB; 494748at2759; -.
DR PhylomeDB; Q6DKF0; -.
DR TreeFam; TF331484; -.
DR PRO; PR:Q6DKF0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000024789; Expressed in pharyngeal gill and 16 other tissues.
DR ExpressionAtlas; Q6DKF0; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IDA:ZFIN.
DR GO; GO:0009615; P:response to virus; IDA:ZFIN.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; PTHR11566; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..626
FT /note="Interferon-induced GTP-binding protein MxC"
FT /id="PRO_0000292869"
FT DOMAIN 40..313
FT /note="Dynamin-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT DOMAIN 534..624
FT /note="GED"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT REGION 50..57
FT /note="G1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 75..77
FT /note="G2 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 151..154
FT /note="G3 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 220..223
FT /note="G4 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 252..255
FT /note="G5 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT BINDING 50..57
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 151..155
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 220..223
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT CONFLICT 108
FT /note="E -> G (in Ref. 2; CAD67757)"
FT /evidence="ECO:0000305"
FT CONFLICT 286
FT /note="L -> F (in Ref. 2; CAD67757)"
FT /evidence="ECO:0000305"
FT CONFLICT 302..305
FT /note="EELV -> KKLG (in Ref. 2; CAD67757)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 626 AA; 70735 MW; 6B11C9CBB1FFE025 CRC64;
MSSFDSAEGE CNGLNQHYEK KVRPIIDLVD TLRALGVEKD LNLPAIAVIG DQSSGKSSVL
EALSGVALPR GIGIVTRCPL ILKLKKITRD KNWSGLLTYK DQTEILKEPT GIENAVLKAQ
IALAGTGEGI SHEMITLEIQ SCDVPDLTLI DLPGIARVAT GNQPEDIEKQ IKDLIEKFIK
RQETISLVVV PANIDIATTE ALKMASTVDP TGQRTLCILT KPDLVDRGME DTVVRTVNNE
VIRLEKGYMI VKCRGQQDIN DKLNLVEALE KERRFFDEHP QFSSLLEDGK ATIPLLGQRL
TEELVEHIAK NVPRLQNQIE MKLQKTFERL KVLGESVPDD DEIELNNFLI KKLRQFMDAL
EEVKRVEEEP VKSDTRVFSK IRQEFVSWKH ILDSKPIKMS TDLQEYVRTH RGKELPGFLN
YGTFAGIIRM HVEDLEEPAL KLLRNAKDIV HSSVGSIANI HFNGYPNLLL AVKEPIEKCL
HEQFQNAEEK IRSQFKLEKT VYCQDDLYTN HLNLLRPKNT VRFGLEASLG NSELRETAFH
LTSYLTIACE RLANQIPLIV QYHMMNEYNS QLQNAMLGLI GTSDPGMLLC EDSGVARIRK
DLKERLERLK DARRALPKVV HSANSW
