ID   MXE_DANRE               Reviewed;         625 AA.
AC   Q800G5;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Interferon-induced GTP-binding protein MxE;
DE   AltName: Full=IFN-inducible antiviral protein MxE;
DE   AltName: Full=Interferon-inducible MxE protein;
GN   Name=mxe;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12869211; DOI=10.1186/1471-2164-4-29;
RA   Lutfalla G., Roest Crollius H., Stange-Thomann N., Jaillon O., Mogensen K.,
RA   Monneron D.;
RT   "Comparative genomic analysis reveals independent expansion of a lineage-
RT   specific gene family in vertebrates: the class II cytokine receptors and
RT   their ligands in mammals and fish.";
RL   BMC Genomics 4:29-29(2003).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By interferons.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
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DR   EMBL; AJ544827; CAD67759.1; -; mRNA.
DR   RefSeq; NP_878287.1; NM_182867.1.
DR   AlphaFoldDB; Q800G5; -.
DR   SMR; Q800G5; -.
DR   STRING; 7955.ENSDARP00000091708; -.
DR   PaxDb; Q800G5; -.
DR   PRIDE; Q800G5; -.
DR   Ensembl; ENSDART00000142227; ENSDARP00000118741; ENSDARG00000014427.
DR   GeneID; 337663; -.
DR   KEGG; dre:337663; -.
DR   CTD; 337663; -.
DR   ZFIN; ZDB-GENE-030131-9609; mxe.
DR   eggNOG; KOG0446; Eukaryota.
DR   GeneTree; ENSGT00940000164201; -.
DR   HOGENOM; CLU_008964_8_0_1; -.
DR   InParanoid; Q800G5; -.
DR   PhylomeDB; Q800G5; -.
DR   TreeFam; TF331484; -.
DR   PRO; PR:Q800G5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000014427; Expressed in spleen and 15 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR   GO; GO:0009615; P:response to virus; IDA:ZFIN.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; PTHR11566; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..625
FT                   /note="Interferon-induced GTP-binding protein MxE"
FT                   /id="PRO_0000292870"
FT   DOMAIN          40..313
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   DOMAIN          536..625
FT                   /note="GED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT   REGION          50..57
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          75..77
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          151..154
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          220..223
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          252..255
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   BINDING         50..57
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         151..155
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         220..223
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   625 AA;  70395 MW;  3AB63E70B41B4ED6 CRC64;
     MSPSGSTKGE SSGLNQHYEE KVRPCIDLVD SLRALGVEKD LNLPAIAVIG DQSSGKSSVL
     EALSGVALPR GTGIVTRCPL VLKLKKITKD KSWHGLLTYN DKIRELKDPA KIEKAVLNAQ
     TALAGIGEGI SHEMITLEIQ SCDVPDLTLI DLPGIARVAT GNQPEDIEKQ IKSLIEKFIK
     RQETISLVVV PANIDIATTE ALKMASTVDP TGQRTLGILT KPDLVDRGME DTVVRTVNNE
     VIPLKKGYMI VKCRGQQDIN DKLGLVEALE KERRFFDENV HFRSLLEDRK ATIPLLAERL
     TKELVEHIAK NLPQLQNQLE MKLEKTSADL RGLGDGVPLD KNEKSNFLIM KIRQFNDVLE
     RVQMAEEDVE KPNTRVFSKI RSEFVKWKRI LDSKAIKTEE TLRDEVQEYV KTRRGKELPG
     FVNYRTFENI VKKHIAELHE PALKLLKDVT DIVHSSVDHI VNAHFSSFSP LMRAAKDPTE
     DFLHEQFQRA EEKIHSQFRM EKIVYSQDDL YSDQLTTAKN TLRGYGLQSP NVSADVREMA
     YHLTSYLTIA CERLANQIPL IVQYHMLNQY ISQLQNAMLG LIGKNSPGML LCEDSGVARK
     RKDLKERLER LKSAGRVLSK FVHSA