ID   MXIA_SHISO              Reviewed;         686 AA.
AC   P0A1I6; P35533; Q55295;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Protein MxiA;
DE   AltName: Full=Protein VirH;
GN   Name=mxiA; Synonyms=virH;
OS   Shigella sonnei.
OG   Plasmid pINV.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HW383;
RA   Arakawa E., Kato J., Ito K., Watanabe H.;
RT   "Comparison and high conservation of nucleotide sequences of spa-mxi
RT   regions between S.sonnei and S.flexneri -- identification of a new gene
RT   coding plausible membrane protein.";
RL   Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for the secretion of IPA invasins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC       pore) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA09156.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D50601; BAA09156.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000616104.1; NZ_UIQD01000016.1.
DR   RefSeq; WP_000864772.1; NZ_JACMSG010000040.1.
DR   AlphaFoldDB; P0A1I6; -.
DR   SMR; P0A1I6; -.
DR   STRING; 216599.GCA_000283715_05238; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 1.10.8.540; -; 1.
DR   Gene3D; 3.40.30.60; -; 1.
DR   Gene3D; 3.40.50.12790; -; 1.
DR   InterPro; IPR042194; FHIPEP_1.
DR   InterPro; IPR042193; FHIPEP_3.
DR   InterPro; IPR042196; FHIPEP_4.
DR   InterPro; IPR025505; FHIPEP_CS.
DR   InterPro; IPR001712; T3SS_FHIPEP.
DR   InterPro; IPR006302; T3SS_HrcV.
DR   PANTHER; PTHR30161; PTHR30161; 1.
DR   Pfam; PF00771; FHIPEP; 1.
DR   PIRSF; PIRSF005419; FlhA; 1.
DR   PRINTS; PR00949; TYPE3IMAPROT.
DR   TIGRFAMs; TIGR01399; hrcV; 1.
DR   PROSITE; PS00994; FHIPEP; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Plasmid; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..686
FT                   /note="Protein MxiA"
FT                   /id="PRO_0000190033"
FT   TRANSMEM        28..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   686 AA;  76145 MW;  BD675C2C3BED820F CRC64;
     MIQSFLKQVS TKPELIILVL MVMIIAMLII PLPTYLVDFL IGLNIVLAIL VFMGSFYIER
     ILSFSTFPSV LLITTLFRLA LSISTSRLIL VDADAGKIIT TFGQFVIGDS LAVGFVIFSI
     VTVVQFIVIT KGSERVAEVA ARFSLDGMPG KQMSIDADLK AGIIDAAGAK ERRSILERES
     QLYGSFDGAM KFIKGDAIAG IIIIFVNLIG GISVGMSQHG MSLSGALSTY TILTIGDGLV
     SQIPALLISI SAGFIVTRVN GDSDNMGRNI MSQIFGNPFV LIVTSALALA IGMLPGFPFF
     VFFLIAVTLT ALFYYKKVVE KEKSLSESDS SGYTGTFDID NSHDSSLAMI ENLDAISSET
     VPLILLFAEN KINANDMEGL IERIRSQFFI DYGVRLPTIL YRTSNELKVD DIVLLINEVR
     ADSFNIYFDK VCITDENGDI DALGIPVVST SYNERVISWV DVSYTENLTN IDAKIKSAQD
     EFYHQLSQAL LNNINEIFGI QETKNMLDQF ENRYPDLLKE VFRHVTIQRI SEVLQRLLGE
     NISVRNLKLI MESLALWAPR EKDVITLVEH VRASLSRYIC SKIAVSGEIK VVMLSGYIED
     AIRKGIRQTS GGSFLNMDIE VSDEVMETLA HALRELRNAK KNFVLLVSVD IRRFVKRLID
     NRFKSILVIS YAEIDEAYTI NVLKTI