ID   MXIH_SHIFL              Reviewed;          83 AA.
AC   P0A223; Q06079; Q6LAA7;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Protein MxiH;
GN   Name=mxiH; OrderedLocusNames=CP0137;
OS   Shigella flexneri.
OG   Plasmid pWR100, and Plasmid pCP301.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=1332940; DOI=10.1128/jb.174.23.7661-7669.1992;
RA   Allaoui A., Sansonetti P.J., Parsot C.;
RT   "MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is
RT   homologous to YscJ, a secretion factor of the Yersinia Yop proteins.";
RL   J. Bacteriol. 174:7661-7669(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=11115111; DOI=10.1046/j.1365-2958.2000.02179.x;
RA   Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H.,
RA   Kunst F., Sansonetti P.J., Parsot C.;
RT   "The virulence plasmid pWR100 and the repertoire of proteins secreted by
RT   the type III secretion apparatus of Shigella flexneri.";
RL   Mol. Microbiol. 38:760-771(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=11292750; DOI=10.1128/iai.69.5.3271-3285.2001;
RA   Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V.,
RA   Blattner F.R.;
RT   "Complete DNA sequence and analysis of the large virulence plasmid of
RT   Shigella flexneri.";
RL   Infect. Immun. 69:3271-3285(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a; PLASMID=pCP301;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-13.
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=8559065; DOI=10.1111/j.1365-2958.1995.mmi_17030461.x;
RA   Allaoui A., Sansonetti P.J., Menard R., Barzu S., Mounier J., Phalipon A.,
RA   Parsot C.;
RT   "MxiG, a membrane protein required for secretion of Shigella spp. Ipa
RT   invasins: involvement in entry into epithelial cells and in intercellular
RT   dissemination.";
RL   Mol. Microbiol. 17:461-470(1995).
CC   -!- FUNCTION: Necessary for the secretion of IPA invasins.
CC   -!- INTERACTION:
CC       P0A223; P0A223: mxiH; NbExp=2; IntAct=EBI-15861163, EBI-15861163;
CC   -!- SIMILARITY: Belongs to the MxiH/PrgI/YscF family. {ECO:0000305}.
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DR   EMBL; M98390; AAA26530.1; -; Genomic_DNA.
DR   EMBL; AL391753; CAC05812.1; -; Genomic_DNA.
DR   EMBL; AF348706; AAK18456.1; -; Genomic_DNA.
DR   EMBL; AF386526; AAL72553.1; -; Genomic_DNA.
DR   EMBL; Z48957; CAA88823.1; -; Genomic_DNA.
DR   PIR; A45271; A45271.
DR   RefSeq; NP_085300.1; NC_002698.1.
DR   RefSeq; NP_858270.1; NC_004851.1.
DR   RefSeq; WP_010921669.1; NZ_WPGS01000043.1.
DR   RefSeq; YP_009062494.1; NC_024996.1.
DR   PDB; 2CA5; X-ray; 2.10 A; A/B=1-78.
DR   PDB; 2V6L; EM; 16.00 A; 0/1/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z=1-83.
DR   PDB; 3J0R; EM; 7.70 A; A=2-83.
DR   PDB; 6RWY; EM; 5.11 A; L/M/N/O/P/Q/R/S/T/U/V=1-83.
DR   PDB; 6ZNI; EM; 3.60 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W=1-83.
DR   PDBsum; 2CA5; -.
DR   PDBsum; 2V6L; -.
DR   PDBsum; 3J0R; -.
DR   PDBsum; 6RWY; -.
DR   PDBsum; 6ZNI; -.
DR   AlphaFoldDB; P0A223; -.
DR   SMR; P0A223; -.
DR   DIP; DIP-59026N; -.
DR   STRING; 198214.CP0137; -.
DR   EnsemblBacteria; AAL72553; AAL72553; SF_p0137.
DR   GeneID; 1238256; -.
DR   KEGG; sfl:CP0137; -.
DR   HOGENOM; CLU_171855_1_1_6; -.
DR   OMA; PNKDWTL; -.
DR   EvolutionaryTrace; P0A223; -.
DR   Proteomes; UP000001006; Plasmid pCP301.
DR   GO; GO:0030257; C:type III protein secretion system complex; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR   InterPro; IPR021123; T3SS_needle-like.
DR   InterPro; IPR037203; T3SS_needle-like_sf.
DR   InterPro; IPR011841; T3SS_needle_YscF.
DR   Pfam; PF09392; T3SS_needle_F; 1.
DR   SUPFAM; SSF140129; SSF140129; 1.
DR   TIGRFAMs; TIGR02105; III_needle; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Plasmid; Protein transport; Reference proteome; Transport;
KW   Virulence.
FT   CHAIN           1..83
FT                   /note="Protein MxiH"
FT                   /id="PRO_0000096659"
FT   HELIX           22..39
FT                   /evidence="ECO:0007829|PDB:2CA5"
FT   HELIX           44..79
FT                   /evidence="ECO:0007829|PDB:2CA5"
SQ   SEQUENCE   83 AA;  9265 MW;  BA4D517D145345DC CRC64;
     MSVTVPNDDW TLSSLSETFD DGTQTLQGEL TLALDKLAKN PSNPQLLAEY QSKLSEYTLY
     RNAQSNTVKV IKDVDAAIIQ NFR