MXL1_CAEEL
ID MXL1_CAEEL Reviewed; 124 AA.
AC G5EEH5;
DT 10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Max-like protein 1 {ECO:0000303|PubMed:9764821};
GN Name=mxl-1 {ECO:0000312|WormBase:T19B10.11};
GN ORFNames=T19B10.11 {ECO:0000312|WormBase:T19B10.11};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAB40926.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, AND DEVELOPMENTAL STAGE.
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:AAB40926.1};
RX PubMed=9764821; DOI=10.1038/sj.onc.1202036;
RA Yuan J., Tirabassi R.S., Bush A.B., Cole M.D.;
RT "The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for
RT vertebrate MAD and MAX.";
RL Oncogene 17:1109-1118(1998).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24699255; DOI=10.1371/journal.pgen.1004278;
RA Johnson D.W., Llop J.R., Farrell S.F., Yuan J., Stolzenburg L.R.,
RA Samuelson A.V.;
RT "The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse
RT longevity signals.";
RL PLoS Genet. 10:e1004278-e1004278(2014).
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=27402359; DOI=10.1534/g3.116.029983;
RA Botts M.R., Cohen L.B., Probert C.S., Wu F., Troemel E.R.;
RT "Microsporidia Intracellular Development Relies on Myc Interaction Network
RT Transcription Factors in the Host.";
RL G3 (Bethesda) 6:2707-2716(2016).
CC -!- FUNCTION: Transcriptional regulator which binds to the E box motif 5'-
CC CACGTG-3', when in a heterodimeric complex with mdl-1 (PubMed:9764821).
CC Involved in the control of lifespan in response to dietary restriction,
CC the decline in protein homeostasis associated with normal aging and may
CC overlap with the insulin-like signaling pathway (PubMed:24699255).
CC Involved in promoting infection by the microsporidian pathogen
CC N.parisii (PubMed:27402359). {ECO:0000269|PubMed:24699255,
CC ECO:0000269|PubMed:27402359, ECO:0000269|PubMed:9764821}.
CC -!- SUBUNIT: Heterodimer with mdl-1 in presence and absence of DNA.
CC {ECO:0000269|PubMed:9764821}.
CC -!- INTERACTION:
CC G5EEH5; G5EG44: mdl-1; NbExp=5; IntAct=EBI-1182982, EBI-1182971;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- DEVELOPMENTAL STAGE: Expressed weakly in L1 animals and strongly
CC throughout the remainder of larval development (PubMed:9764821).
CC Expressed in posterior intestinal cells, neurons, hypodermal cells and
CC body wall muscles (PubMed:9764821). {ECO:0000269|PubMed:9764821}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown increases lifespan, which
CC is abolished on an mxl-2 or mml-1 mutant background, or by simultaneous
CC RNAi-mediated knockdown of daf-16 or pha-4 (PubMed:24699255). RNAi-
CC mediated knockdown causes delayed onset of polyglutamine-mediated
CC paralysis (PubMed:24699255). {ECO:0000269|PubMed:24699255}.
CC -!- SIMILARITY: Belongs to the MAX family. {ECO:0000305}.
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DR EMBL; U82967; AAB40926.1; -; mRNA.
DR EMBL; BX284605; CAA98543.1; -; Genomic_DNA.
DR PIR; T24979; T24979.
DR RefSeq; NP_505856.1; NM_073455.4.
DR AlphaFoldDB; G5EEH5; -.
DR SMR; G5EEH5; -.
DR IntAct; G5EEH5; 1.
DR STRING; 6239.T19B10.11; -.
DR EPD; G5EEH5; -.
DR PaxDb; G5EEH5; -.
DR EnsemblMetazoa; T19B10.11.1; T19B10.11.1; WBGene00003509.
DR GeneID; 179557; -.
DR KEGG; cel:CELE_T19B10.11; -.
DR CTD; 179557; -.
DR WormBase; T19B10.11; CE16417; WBGene00003509; mxl-1.
DR eggNOG; KOG2483; Eukaryota.
DR GeneTree; ENSGT00530000064011; -.
DR HOGENOM; CLU_109424_1_1_1; -.
DR InParanoid; G5EEH5; -.
DR OMA; PALHINE; -.
DR OrthoDB; 1588329at2759; -.
DR PhylomeDB; G5EEH5; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003509; Expressed in embryo and 3 other tissues.
DR GO; GO:0071339; C:MLL1 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IPI:WormBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0019904; F:protein domain specific binding; IPI:WormBase.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:WormBase.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:InterPro.
DR GO; GO:0007568; P:aging; IMP:UniProtKB.
DR GO; GO:0008340; P:determination of adult lifespan; IGI:WormBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR037933; MAX-like.
DR InterPro; IPR002418; Tscrpt_reg_Myc.
DR PANTHER; PTHR10328; PTHR10328; 1.
DR Pfam; PF00010; HLH; 1.
DR PRINTS; PR00044; LEUZIPPRMYC.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Coiled coil; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..124
FT /note="Max-like protein 1"
FT /id="PRO_0000451994"
FT DOMAIN 29..82
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 29..42
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 43..82
FT /note="Helix-loop-helix motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT COILED 86..113
FT /evidence="ECO:0000255"
FT COMPBIAS 7..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 124 AA; 13843 MW; 8E780B9D00B82B0D CRC64;
MSDMSDLEDD QTGHCGSGEH SGPFDPKRHA REQHNALERR RRDNIKDMYT SLREVVPDAN
GERVQASRAV ILKKAIESIE KGQSDSATLS VDVAEQESKN AKLREEIARL KAKKDPSSSQ
SIIQ
