MXRA7_HUMAN
ID MXRA7_HUMAN Reviewed; 204 AA.
AC P84157; Q0P5W3;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Matrix-remodeling-associated protein 7;
GN Name=MXRA7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 75-204 (ISOFORM 3).
RA Walker M.G., Volkmuth W.;
RT "Matrix-remodeling associated genes identified by co-expression.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP IDENTIFICATION.
RA Southan C., Hearath A., Rohlff C.;
RT "Characterising unknown proteins by location proteomics.";
RL Submitted (AUG-2004) to UniProtKB.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=P84157-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P84157-2; Sequence=VSP_022589, VSP_022590;
CC Name=3;
CC IsoId=P84157-3; Sequence=VSP_024252;
CC -!- SEQUENCE CAUTION:
CC Sequence=AW888225; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC005837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC053983; AAH53983.1; -; mRNA.
DR EMBL; AW888225; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS32745.1; -. [P84157-1]
DR CCDS; CCDS32746.1; -. [P84157-3]
DR CCDS; CCDS45786.1; -. [P84157-2]
DR RefSeq; NP_001008528.1; NM_001008528.2. [P84157-1]
DR RefSeq; NP_001008529.1; NM_001008529.2. [P84157-3]
DR RefSeq; NP_940932.2; NM_198530.3. [P84157-2]
DR AlphaFoldDB; P84157; -.
DR SMR; P84157; -.
DR BioGRID; 136132; 64.
DR IntAct; P84157; 8.
DR MINT; P84157; -.
DR STRING; 9606.ENSP00000348050; -.
DR GlyGen; P84157; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; P84157; -.
DR PhosphoSitePlus; P84157; -.
DR BioMuta; MXRA7; -.
DR DMDM; 52783434; -.
DR EPD; P84157; -.
DR jPOST; P84157; -.
DR MassIVE; P84157; -.
DR MaxQB; P84157; -.
DR PaxDb; P84157; -.
DR PeptideAtlas; P84157; -.
DR PRIDE; P84157; -.
DR ProteomicsDB; 57754; -. [P84157-1]
DR ProteomicsDB; 57755; -. [P84157-2]
DR ProteomicsDB; 57756; -. [P84157-3]
DR Antibodypedia; 46164; 42 antibodies from 17 providers.
DR DNASU; 439921; -.
DR Ensembl; ENST00000355797.7; ENSP00000348050.2; ENSG00000182534.14. [P84157-1]
DR Ensembl; ENST00000375036.6; ENSP00000364176.1; ENSG00000182534.14. [P84157-3]
DR Ensembl; ENST00000449428.7; ENSP00000391466.1; ENSG00000182534.14. [P84157-2]
DR GeneID; 439921; -.
DR KEGG; hsa:439921; -.
DR MANE-Select; ENST00000449428.7; ENSP00000391466.1; NM_198530.4; NP_940932.2. [P84157-2]
DR UCSC; uc002jsk.2; human. [P84157-1]
DR CTD; 439921; -.
DR DisGeNET; 439921; -.
DR GeneCards; MXRA7; -.
DR HGNC; HGNC:7541; MXRA7.
DR HPA; ENSG00000182534; Low tissue specificity.
DR neXtProt; NX_P84157; -.
DR OpenTargets; ENSG00000182534; -.
DR PharmGKB; PA31342; -.
DR VEuPathDB; HostDB:ENSG00000182534; -.
DR eggNOG; ENOG502SAE0; Eukaryota.
DR GeneTree; ENSGT00940000165365; -.
DR HOGENOM; CLU_117235_0_0_1; -.
DR InParanoid; P84157; -.
DR OMA; CPFEIAG; -.
DR OrthoDB; 1284052at2759; -.
DR PhylomeDB; P84157; -.
DR TreeFam; TF336065; -.
DR PathwayCommons; P84157; -.
DR SignaLink; P84157; -.
DR BioGRID-ORCS; 439921; 71 hits in 1077 CRISPR screens.
DR ChiTaRS; MXRA7; human.
DR GenomeRNAi; 439921; -.
DR Pharos; P84157; Tdark.
DR PRO; PR:P84157; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P84157; protein.
DR Bgee; ENSG00000182534; Expressed in saphenous vein and 216 other tissues.
DR ExpressionAtlas; P84157; baseline and differential.
DR Genevisible; P84157; HS.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026622; Mxra7.
DR PANTHER; PTHR21845; PTHR21845; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..204
FT /note="Matrix-remodeling-associated protein 7"
FT /id="PRO_0000072586"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 32..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..71
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 191
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CZH7"
FT VAR_SEQ 168..204
FT /note="VQKEQLAAIFKLMKDNKETFGEMSDGDVQEQLRLYDM -> IELTSDLTSL
FT (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_024252"
FT VAR_SEQ 168..170
FT /note="VQK -> TEE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022589"
FT VAR_SEQ 171..204
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022590"
FT CONFLICT 80
FT /note="L -> V (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 204 AA; 21466 MW; 3298195FCAC7AECF CRC64;
MEAPAELLAA LPALATALAL LLAWLLVRRG AAASPEPARA PPEPAPPAEA TGAPAPSRPC
APEPAASPAG PEEPGEPAGL GELGEPAGPG EPEGPGDPAA APAEAEEQAV EARQEEEQDL
DGEKGPSSEG PEEEDGEGFS FKYSPGKLRG NQYKKMMTKE ELEEEQRVQK EQLAAIFKLM
KDNKETFGEM SDGDVQEQLR LYDM
