ID   MX_ANAPL                Reviewed;         721 AA.
AC   P33238; P33239;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Interferon-induced GTP-binding protein Mx;
DE   AltName: Full=Interferon-inducible Mx protein;
GN   Name=MX;
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8839;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8100373; DOI=10.1006/viro.1993.1350;
RA   Bazzigher L., Schwarz A., Staeheli P.;
RT   "No enhanced influenza virus resistance of murine and avian cells
RT   expressing cloned duck Mx protein.";
RL   Virology 195:100-112(1993).
CC   -!- FUNCTION: Does not show activity against influenza virus or VSV.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- INDUCTION: By interferons.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
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DR   EMBL; Z21549; CAA79731.1; -; mRNA.
DR   EMBL; Z21550; CAA79732.1; -; mRNA.
DR   PIR; A37472; A37472.
DR   PIR; S31820; S31820.
DR   PIR; S31824; S31824.
DR   RefSeq; NP_001297338.1; NM_001310409.1.
DR   AlphaFoldDB; P33238; -.
DR   SMR; P33238; -.
DR   GeneID; 101793492; -.
DR   KEGG; apla:101793492; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; PTHR11566; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Nucleus.
FT   CHAIN           1..721
FT                   /note="Interferon-induced GTP-binding protein Mx"
FT                   /id="PRO_0000206602"
FT   DOMAIN          128..401
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   DOMAIN          632..721
FT                   /note="GED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..145
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          163..165
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          239..242
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          308..311
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          340..343
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   BINDING         138..145
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         239..243
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         308..311
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   VARIANT         5
FT                   /note="R -> H"
FT   VARIANT         82
FT                   /note="E -> K"
FT   VARIANT         231
FT                   /note="Y -> H"
FT   VARIANT         322
FT                   /note="I -> V"
FT   VARIANT         371
FT                   /note="S -> R"
FT   VARIANT         615
FT                   /note="S -> G"
FT   VARIANT         626
FT                   /note="D -> A"
SQ   SEQUENCE   721 AA;  81953 MW;  311FF966202E7660 CRC64;
     MTTQRNTDKP HSKPEDQWNM YNRNPKFKAT AKRCSPNLMK DGFQSLSSPV CIEASAVPLP
     PDSDDEIYFP VPEQTTKESQ HEQKVSMKLH EEQDVQAAEH TLYNQYEEKI RPCIDLIDSL
     RALGIEKDLS LPAIAVIGDQ SSGKSSILEA LSGVSLPRGN GIVTRCPLEL KLKKIPTSQE
     WKGKISYRNI STDLQHASEV ENAIRNAQDV VAGTKGNISG ELISLEICSP YVPDLTLIDL
     PGIARVAMRN QPQDIGEQIK KLIKKIISSK ETINLVVVPC NVDIATTEAL KMAQEVDPKG
     ERTLGILTKP DLVDIGTEEY IISIVQNEVI PLRKGYMVVK CRGQRDIHNK LTLASAIHQE
     RQFFETHKCF SILLDQNKAT IPHLAMKLTN ELVAHIIKTL PTIESQIREV LQKSVQELQK
     YRRGTPTIET EKLAFLTDLI KLFNQDVSRV ICGEEHLFGN EIRLFAKLRK EFQTWGLLLL
     ENAAKVQKSI PSKMWKYEDQ YRGREFPGFI NYRTFEDIIK EQILDLEEPA IVILNNVIRL
     VEEKFLELTN KHFANFKNLN RAAQTKIDVI RNTQAMNAEN HIRNQFKMER IVYCQDNIYL
     DDLRSTKAEI LGKDSGKEIS FASVSDKNAI FIQEMISHTK AYFTGASKRL SNQIPLIILS
     AVLHDFGDNL QSSMLHLLQE REKLNSLLQE NSEAAKMRNY LSGRVNRLSK AYQCLKDFSC
     L