MX_CHICK
ID MX_CHICK Reviewed; 705 AA.
AC Q90597; Q0KKN7; Q0PMS3; Q0PMS4; Q0PMS5; Q0PMS6; Q8JFB6; Q8JIF6; Q8JIF7;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Interferon-induced GTP-binding protein Mx;
DE AltName: Full=Interferon-inducible Mx protein;
GN Name=MX;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn;
RX PubMed=7648434; DOI=10.1089/jir.1995.15.47;
RA Bernasconi D., Schultz U., Staeheli P.;
RT "The interferon-induced Mx protein of chickens lacks antiviral activity.";
RL J. Interferon Cytokine Res. 15:47-53(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Black Minorca, Fayoumi GSP, WL-F, and WL-N;
RA Chang K.S., Ohashi K., Onuma M.;
RT "Transcription activities and antiviral effects of chicken Mx genes induced
RT from the various MHC haplotype chickens.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Black-bone;
RA Ding Y.L., Xia C.;
RT "Clone and expression of the Mx of WuJi.";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=16, 17, 25, and 7;
RA Li X.Y., Qu L.J., Yao J.F., Hou Z.C., Yang N.;
RT "Genomic structure and variation of chicken MX gene.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Does not show activity against influenza virus, VSV, Thogoto
CC virus or Sendai virus.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- INDUCTION: By interferons.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC ProRule:PRU01055}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z23168; CAA80686.1; -; mRNA.
DR EMBL; AB088533; BAC06346.1; -; mRNA.
DR EMBL; AB088534; BAC06347.1; -; mRNA.
DR EMBL; AB088535; BAC06348.1; -; mRNA.
DR EMBL; AB088536; BAC06349.1; -; mRNA.
DR EMBL; AB244818; BAF30836.1; -; mRNA.
DR EMBL; DQ788613; ABH07788.1; -; Genomic_DNA.
DR EMBL; DQ788614; ABH07789.1; -; Genomic_DNA.
DR EMBL; DQ788615; ABH07790.1; -; Genomic_DNA.
DR EMBL; DQ788616; ABH07791.1; -; Genomic_DNA.
DR PIR; S34155; S34155.
DR RefSeq; NP_989940.1; NM_204609.1.
DR AlphaFoldDB; Q90597; -.
DR SMR; Q90597; -.
DR STRING; 9031.ENSGALP00000025952; -.
DR PaxDb; Q90597; -.
DR GeneID; 395313; -.
DR KEGG; gga:395313; -.
DR CTD; 4599; -.
DR VEuPathDB; HostDB:geneid_395313; -.
DR eggNOG; KOG0446; Eukaryota.
DR InParanoid; Q90597; -.
DR OrthoDB; 494748at2759; -.
DR PhylomeDB; Q90597; -.
DR PRO; PR:Q90597; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; PTHR11566; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..705
FT /note="Interferon-induced GTP-binding protein Mx"
FT /id="PRO_0000206603"
FT DOMAIN 111..384
FT /note="Dynamin-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT DOMAIN 616..705
FT /note="GED"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT REGION 60..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..128
FT /note="G1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 146..148
FT /note="G2 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 222..225
FT /note="G3 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 291..294
FT /note="G4 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 323..326
FT /note="G5 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT BINDING 121..128
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 222..226
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 291..294
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT VARIANT 5
FT /note="W -> R (in strain: 16, 17, 25, 7, Black Minorca,
FT Fayoumi GSP, WL-F and WL-N)"
FT VARIANT 8
FT /note="F -> S (in strain: Black-bone)"
FT VARIANT 21
FT /note="Q -> R (in strain: 25, Black Minorca, Fayoumi GSP
FT and WL-F)"
FT VARIANT 41
FT /note="R -> P (in strain: 16, 17, 25, Black Minorca,
FT Fayoumi GSP and WL-F)"
FT VARIANT 42
FT /note="S -> L (in strain: 16, 17, 25, Black Minorca,
FT Fayoumi GSP and WL-F)"
FT VARIANT 72
FT /note="D -> N (in strain: WL-N)"
FT VARIANT 84
FT /note="S -> N (in strain: WL-N)"
FT VARIANT 94
FT /note="Q -> R (in strain: 16, 17, 25, 7, Black-bone, Black
FT Minorca, Fayoumi GSP, WL-F and WL-N)"
FT VARIANT 143
FT /note="K -> E (in strain: WL-F)"
FT VARIANT 152
FT /note="E -> K (in strain: WL-F)"
FT VARIANT 158
FT /note="M -> V (in strain: WL-N)"
FT VARIANT 202
FT /note="S -> T (in strain: 16, 17)"
FT VARIANT 308
FT /note="I -> V (in strain: 25, 7, Black-bone, Black Minorca,
FT Fayoumi GSP, WL-F and WL-N)"
FT VARIANT 317
FT /note="K -> E (in strain: WL-F)"
FT VARIANT 339
FT /note="A -> T (in strain: 25, 7, Black-bone, Black Minorca,
FT Fayoumi GSP, WL-F and WL-N)"
FT VARIANT 352
FT /note="H -> R (in strain: WL-N)"
FT VARIANT 377
FT /note="G -> E (in strain: Black-bone)"
FT VARIANT 505
FT /note="Q -> R (in strain: Black Minorca and Fayoumi GSP)"
FT VARIANT 530
FT /note="Q -> R (in strain: Black-bone)"
FT VARIANT 548
FT /note="A -> V (in strain: 25, WL-F and WL-N)"
FT VARIANT 583
FT /note="A -> T (in strain: 16, 17, 25, 7, Black-bone, Black
FT Minorca, Fayoumi GSP, WL-F and WL-N)"
FT VARIANT 631
FT /note="S -> N (in strain: 25, Black-bone, WL-F and WL-N)"
SQ SEQUENCE 705 AA; 79493 MW; 88378C25B737482B CRC64;
MNNPWSNFSS AFGCPIQIPK QNSNVPPSLP VPVGVFGVPL RSGCSNQMAF CAPELTDRKP
EHEQKVSKRL NDREEDKDEA AACSLDNQYD RKIQPCIDLV DSLRKLDIGN DLMLPAIAVI
GDRNSGKSSV LEALSGVALP RDKGVITRCP LELKLKKMTA PQEWKGVIYY RNTEIQLQNA
SEVKKAIRKA QDIVAGTNGS ISGELISLEI WSPDVPDLTL IDLPGIAREA VGNQPQDNGQ
QIKTLLKKYI GCKETIIVVV VPCNVDIATT EALKMAQEVD PTGERTLGVL TKPDLVNEGT
EETVLKIIQN EVIPLRKGYM IVKCYGQMDF CNELSFTSAI QQEREFFETH KHFSTLLDEN
KATIPHLANK LTDELVGRII KTLPAIEKQV HDALQQAKKE LQKYTQSTHP TVSDKTIFLV
GLIKAFNEDI SQTMHGKESW FGNEIRLFPK IRREFRTWGV KLLESSAKVE EIVCSKLPKY
EDQYRGREFP DFISYWTFED IIKEQITKLE EPAVAMLNKV IYMVEEKFLQ LANKRFANFQ
NLNNAAQARI GCISDRQATT AKNCILTQFK MERIIYCQDN IYADDLKAAR AEGISKDTKI
KDLAFGCASR QCPSFALEMV SHVKAYFTGA SKRLSNQIPL IILSTVLHDF GNYLQTSMLH
LLQGKEEINY LLQEDHEAAN QQKLLTSRIS HLNKAYQYLV DFKSL
