ID   MX_CTEID                Reviewed;         627 AA.
AC   Q6TKS7;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Interferon-induced GTP-binding protein Mx;
DE   AltName: Full=Interferon-inducible Mx protein;
GN   Name=mx;
OS   Ctenopharyngodon idella (Grass carp) (Leuciscus idella).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Xenocyprididae; Xenocypridinae; Ctenopharyngodon.
OX   NCBI_TaxID=7959;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Luo J., Wu H., Bai J., Lao H., Ye X., Jian Q.;
RT   "The gene cloning and analysis of Mx of grass carp.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By interferons.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
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DR   EMBL; AY395698; AAQ95584.1; -; mRNA.
DR   AlphaFoldDB; Q6TKS7; -.
DR   SMR; Q6TKS7; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; PTHR11566; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding.
FT   CHAIN           1..627
FT                   /note="Interferon-induced GTP-binding protein Mx"
FT                   /id="PRO_0000292866"
FT   DOMAIN          40..316
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   DOMAIN          538..627
FT                   /note="GED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT   REGION          50..57
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          75..77
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          154..157
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          223..226
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          255..258
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   BINDING         50..57
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         154..158
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         223..226
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   627 AA;  71252 MW;  DFADB5C336D9FE09 CRC64;
     MSPSTSSKGK SSGLNQHYEE KVRPCIDLVD SLRSLGVEKD LNLPAIAVIG DQSSGKSSVL
     EALSGVALPR GTGIVTRCPL VLKLKKISKD NNWHQWHGLM SYRDQTKKLK DPAEIENAVL
     KAQTVLAGTG EGISHEMITL EIQSSDVPDL TLIDLPGIAR VATGNQPKDI EKQIKDLIEK
     YIKRQETISL VVVPANIDIA TTEALQMASK VDSTGQRTLG ILTKPDLVDK GMEETVVRTV
     NNQVIQLKKG YMIVKCRGQQ DINEKLDLVE ALEKERHFFD EHAHFRSLLE EGKATIPLLA
     ERLTKELVEH ITKTLPQLQK QLEMKLEKTT EDLRALGAGV PTDEHEKNNF LIAKIRQFID
     ALEGIKKAEE DLRSSDMRVF TKIRKEFDRW KTVLDAKTIK TEETLRDEVE EYVGTRRGRE
     LPGFVNYRTF ENIVKKHIEE LEEPALKLLK DVTDIVHSCV NRIVSSHFKA FSHLLRATKD
     PIEDFLDEQF QKAEEKIHSQ FKMERIVYSQ DHLYSNKLDT VKQNLKVLGQ RPFISAEVRE
     MAQHLTAYFM ITSDHLANQV PLIVQYHILD QYISQLQNAM LAMIGRNNPG MLLQEDSDVA
     RKRRELKERL ERLKSAGKVL SKFVHSV