ID   MX_DICLA                Reviewed;         652 AA.
AC   Q2KTC2; Q2KTC3; Q2KTC4; Q2KTC5;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Interferon-induced GTP-binding protein Mx;
DE   AltName: Full=Interferon-inducible Mx protein;
GN   Name=mx;
OS   Dicentrarchus labrax (European seabass) (Morone labrax).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Moronidae; Dicentrarchus.
OX   NCBI_TaxID=13489;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS VAL-239 AND ARG-457.
RC   STRAIN=1, and 2; TISSUE=Brain;
RA   Buonocore F., Randelli E., Scapigliati G.;
RT   "Cloning and expression of Mx protein from sea bass.";
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By interferons.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
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DR   EMBL; AM228974; CAJ76071.2; -; mRNA.
DR   EMBL; AM228975; CAJ76072.2; -; mRNA.
DR   EMBL; AM228976; CAJ76073.2; -; mRNA.
DR   EMBL; AM228977; CAJ76074.2; -; mRNA.
DR   AlphaFoldDB; Q2KTC2; -.
DR   SMR; Q2KTC2; -.
DR   PRIDE; Q2KTC2; -.
DR   Proteomes; UP000694389; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; PTHR11566; 2.
DR   Pfam; PF01031; Dynamin_M; 2.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..652
FT                   /note="Interferon-induced GTP-binding protein Mx"
FT                   /id="PRO_0000292871"
FT   DOMAIN          30..303
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   DOMAIN          554..645
FT                   /note="GED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT   REGION          40..47
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          65..67
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          141..144
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          210..213
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          242..245
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   BINDING         40..47
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         141..145
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         210..213
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   VARIANT         239
FT                   /note="M -> V"
FT                   /evidence="ECO:0000269|Ref.1"
FT   VARIANT         457
FT                   /note="K -> R"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   652 AA;  73824 MW;  1AB527A8B52EB2A1 CRC64;
     MNALNQQYEE KVRPCIDLID SLRSLGVEKD LALPAIAVIG DQSSGKSSVL EALSGVALPR
     GSGIVTRCPL ELKMKRKNEG EEWYGKITYI GFEENIKDPA DVEKKIREAQ NKIAGPGSGI
     SEDLISLEIA SPDVPDLTLI DLPGIARVAV KGQPENIGDQ IKRLIQKFIT KQETISLVVV
     PCNVDIATTE ALNMAQRVDP DGERTLGILT KPDLVDKGTE ETVVDIVHNE VIHLKKGYMI
     VKCRGQKEIT EKVSLTEAIE REKAFFNDHV FFHTLYNDGH ATVPKLAEKL TLELVHHIEK
     SLPRLEEQIE KKLIETQVEL NKYGNGPPPD TSERLGFLID RVTAFTQDAI SLTSGEELKS
     GVRLNIFSML RKEFAAWKEM IERSGVTFNW NIEKEVAQYE RKYRGRELPG FINYKTFEVM
     VPGFVNYKTF EGMVKEQIKQ LEEPAVLKLK EVAEIVKKEL FKVAQNSFVG FPNLMRAAKM
     MIEAIRKEKE IVAESMLRTQ FKMESIVYTQ DSTYSKKLGK RKREDLQDGV TGLGTQVKLN
     TSSTVGNNGT GATLKEMLKH LKSYYQIAGQ RLADQIPLVI RYQMLQESAV QLQREMLQML
     QDKEKNKVLL HEDSGITNKR IHLQKRLERL SKARLLLTDF SMNIYNFNTT QL