ID   MX_LARCR                Reviewed;         629 AA.
AC   Q000A9;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Interferon-induced GTP-binding protein Mx;
DE   AltName: Full=Interferon-inducible Mx protein;
GN   Name=mx;
OS   Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Sciaenidae; Larimichthys.
OX   NCBI_TaxID=215358;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Xie F., Zhang Z., Lin P., Zou Z., Jia X., Wang Y.;
RT   "Cloning and expression analysis of Mx cDNA from large yellow croaker
RT   (Pseudosciaena crocea).";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By interferons.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
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DR   EMBL; DQ988844; ABJ56003.1; -; mRNA.
DR   AlphaFoldDB; Q000A9; -.
DR   SMR; Q000A9; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; PTHR11566; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding.
FT   CHAIN           1..629
FT                   /note="Interferon-induced GTP-binding protein Mx"
FT                   /id="PRO_0000292875"
FT   DOMAIN          30..303
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   DOMAIN          543..629
FT                   /note="GED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT   REGION          40..47
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          65..67
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          141..144
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          210..213
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          242..245
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          504..523
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         40..47
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         141..145
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         210..213
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   629 AA;  71959 MW;  8999D604E4C6D838 CRC64;
     MNTLNQQYEE KVRPCIDLID SLRSLGVEKD LALPAIAVIG DQSSGKSSVL EALSGVALPR
     GSGIVTRCPL ELKMKRKKEG EEWYGKISYQ DYEEEIEVPA DVEKKIREAQ DKMAGNGVEI
     ADDLISLEIA SPDVPDLTLI ALPGIARVAV KKQPENIGDQ IKRLIQKFIK KQETINLVVV
     PCNMDIATTE ALKMAQEVDP DGERTLVILT KPDLVKKGTE ETVIDIVHNE VIHLKKGYMI
     VKCRGQKEIT EKVSLPEAIE REKAFFKDHA YFHTLYNDGH ATVPKLAEKL TLGLVHHIER
     SLPRLEEQIE EKLEQTRAEL ERYGNGPPTD PAEKLVFLTD KVTAFTQDAI RLTTGEELKC
     GDGLNVFSTL RTEFMKWNAH LNHLGEIFGK RIEREVAQYE EKYRGRELPS FINYKTFEVI
     AKEQIKQLEE LAVKRLKNIG DAVMKVFIQL AKSSFTGFPN LLEKAMTKIN YIKNRNESTA
     ESMLRTQFKM ELLVYSQDRT YSSSLSDRKR EEQQREVDSD QGSVISDNEE RSIVYSTDNH
     ATLQELMVHL KSYYKIASQR LADQIPMVIR YQMLQQSAIQ LQREMMQVLQ DKEKSEVLLK
     EDFDIGSKRA AFQCRLERLM KARRFLTEF